Leonardo de Assis

Scientist by heart and mind. Assistant Professor at the University of Gothenburg.

[Leonardo de Assis @deassisleonardo]

Check out our recent publication on the role of the hepatocyte clock as a therapeutic target in fatty liver disease.
https://t.co/ZAA1EhZLk3

A detailed breakdown is here: https://t.co/MTqaBDyrSs

[Society for Research on Biological Rhythms @SRBR_Outreach]

Recent research shows specialized cells in the retina, ipRGCs, help block intense daylight from resetting our internal clock, explaining why bright light during the day doesn’t throw off our circadian rhythm 🧠🌞.
@SamerHattar @RuchiKomal15
https://t.co/MufdD8aRBs

[Society for Research on Biological Rhythms @SRBR_Outreach]

Circadian biology may feel intuitive to chronobiologists, but it can be tough to navigate for newcomers. Essential Principles and Practice of Circadian Biology: A Road Map is a free, open-access guide to the field for researchers.
Read here: https://t.co/w3Lf4QjZ9B

[Jonas Ludvigsson @ludvigsson]

Today @Gut_BMJ publishes my review titled
➡️My first 1000 manuscript rejections.

I often meet young researchers who are devastated by a manuscript rejection, but rejections are part of life. Here are some of my most memorable ones 😃:
https://t.co/asXsKX3CT6
@karolinskainst

[Leonardo de Assis @deassisleonardo]

Overall, our findings highlight the protective role of the hepatocyte clock, suggesting it as a potential target for MASH treatment!

[Leonardo de Assis @deassisleonardo]

Check out our latest work!

Using a transgenic mouse line with disrupted clocks in hepatocytes, we demonstrated the consequences of such disruptions on daily transcriptome rhythms under physiological conditions and how these disturbances worsen MASH progression!

[biorxiv_pathology @biorxiv_pathol]

Hepatocyte Circadian Clocks Control Cholesterol Metabolism and Protect From Metabolic Dysfunction-Associated Steatohepatitis (MASH) https://t.co/sMkfVklvli #biorxiv_pathol

[Leonardo de Assis @deassisleonardo]

Translating these findings to humans, we observed that MASH patients exhibit disrupted internal phasing, which correlates with increased disease progression.

[Leonardo de Assis @deassisleonardo]

Location: University of Lübeck, Center for Brain, Behavior and Metabolism (CBMM), Institute of Neurobiology

Start date: October 1, 2025; Application deadline: August 8, 2025

Check it out here: https://t.co/23qAhzVPvu

[Leonardo de Assis @deassisleonardo]

Are you ready to explore one of the most exciting frontiers in biomedical research? Join TRR 418

[Leonardo de Assis @deassisleonardo]

If you’re interested in circadian liver metabolism and exercise as a tool to treat fatty liver disease, see the position to work in my lab: PhD Position – Chronotherapy of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (Project B04).

[Brady Holmer @Brady_H]

A recent study of more than 14,000 WHOOP users finds that exercising as close as 4 hours to bedtime can tank your sleep quality.

For example: A maximal-intensity workout ending 2 hours before sleep delayed sleep onset by 36 minutes and reduced sleep duration by 22 minutes.

The same hard workout reduced sleep quality, increased overnight heart rate by 4 bpm, and reduced overnight HRV by 14%.

Exercising more than 4 hours before habitual bedtime was safe - with no impact on sleep - and sometimes appeared to improve sleep quality.

[Leonardo de Assis @deassisleonardo]

More info here:
https://t.co/gdlpUbs1eS

[Leonardo de Assis @deassisleonardo]

PhD Opportunities in Circadian Skin Biology – University of Gothenburg

Are you interested in chronobiology, molecular biology, skin biology, and bioinformatics?

[Leonardo de Assis @deassisleonardo]

Who we're looking for: If you're driven by curiosity, enthusiastic about interdisciplinary research, and keen to participate in this vibrant field—this is your chance!

[Leonardo de Assis @deassisleonardo]

@Mortimert91 Thanks Tom! We will be in touch soon!

[Leonardo de Assis @deassisleonardo]

I'm excited to share that I’m joining the Department of Chemistry and Molecular Biology and the Wallenberg Centre for Molecular and Translational Medicine at the University of Gothenburg, taking on the role of Associate Senior lecturer (Assistant Professor) of Molecular Medicine.