Degen Doc, M.D.

Physician. 52. Building a body my brain can live in.
TMS / ketamine by day. Training, tennis, and n=1 experiments after hours.

[Degen Doc, M.D. @DegenDocMD]

Appreciate it. Glad the post was useful.

I’m pretty new to this space too, and I’ve been pleasantly surprised by how many solid people are in the replies.

I’m staying out of the Jake situation. I don’t know enough to pile on either way.

Hope you find the accounts worth following.

[Degen Doc, M.D. @DegenDocMD]

Both of my parents have Alzheimer’s.

I’m a physician. At 50 I stopped treating that like a distant problem. If I wanted a better shot at keeping my brain, I had to clean up the body around it. Body fat under 15%. Insulin, A1c, hs-CRP, lipids. All of it.

@JayCampbell333 posted the short version. This is the part that mattered to me.

I started tennis 3–5 days a week, Orangetheory, and sauna 4–5 days a week. Hired a trainer in June 2025. I felt better. I still looked like the same guy. Body fat sat at 22.4% for months.

So I quit being stubborn. Low-dose Reta and a GH secretagogue first, because I didn’t want a GLP-1 taking muscle with the fat. Then TRT. Then FLGR-242 after sitting on it for a while.

Not a clean experiment. A lot went in at once.

I feel better at 52 than I did in my 30s. Lasting longer on the court. Hitting PRs weekly in the gym. Labs are better than they’ve been in 20 years.

DEXA is the stricter number. Hume doesn’t match it perfectly, but the trend is obvious:

112.3 lbs lean mass in 2024 → 126.5 today
23.1% body fat → 11.5%

I didn’t do this for a photo.

I did it because I know how this disease goes. I can’t pick my genes. I can pick what I give them to work with.

@NocturnalNelly
@BiohackerJake
@n1after40
@morellifit
@mike_skane

[Jay Campbell @JayCampbell333]

Most GLP-1 users are WRECKING their health by stripping away muscle & staying “Skinny Fat”.

A few SMART ones like @degendocmd are going from 22.4%-13.1% body fat while gaining +14 lbs. of lean mass.

How?

Let me hand you the whole thing. NO GATEKEEPING!

[Degen Doc, M.D. @DegenDocMD]

Good point.

DEXA lean mass ≠ pure muscle. Water, glycogen, organs, connective tissue—it all gets counted. So no, I don’t look at +8.8 lbs of lean mass and assume I gained +8.8 lbs of skeletal muscle.

What I trust more is performance.

I’m hitting strength PRs with my trainer most weeks. That’s the part that feels real.

I’m not a gym bro and I’m not trying to get huge. I just like that training actually feels good now—and I feel better in my own skin than I have in a long time.

[Degen Doc, M.D. @DegenDocMD]

Same here.

No affiliation with BioLongevity or Jay. Paid for everything myself—but yeah, I stocked up when they were doing 50% + another 15% off.

Say what you want about Jay, but I give him credit for pushing this stuff into the mainstream. He and a few others helped move peptides out of the “gym bro only” world and into conversations regular people are actually having.

I’m definitely not a gym bro 😂 Never have been, although I’ve always admired the dedication.

But getting in better shape has made tennis, lifting, and pretty much everything else a lot more fun.

Good luck with the 12-week FLGR242 trial. Definitely curious to see how it goes.

[Degen Doc, M.D. @DegenDocMD]

Means a lot. Thanks.

I’m not going to act like I don’t enjoy looking better. I do. It’s nice to feel more confident in my own skin.

That’s not why I started though. Through my parents, I’ve witnessed the wreckage that Alzheimers does to the person and to everybody around them. I’ve got a 10-year-old and a 3-year-old. That’s the part that sits with me.

The rest is just me trying not to hand them the same story later.

[Degen Doc, M.D. @DegenDocMD]

FLGR crew checking in.

I was already picking up lean mass on TRT — roughly a pound a week in that first stretch.

After adding FLGR-242, DEXA from 6/25 → 8/25:
+8.8 lbs lean
–1.5 lbs fat

About a pound of lean mass per week… while still on Reta, which should make this harder, not easier.

Not a clean single-variable log. But that window is when the scan really moved.

FLGR-242 is the real deal for me.

[Matt Christ @MattDChrist]

FLGR crew stand up! 💯🔥
@NocturnalNelly
@BiohackerJake
@JayCampbell333
@n1after40
@DegenDocMD
@morellifit
@mike_skane

[Degen Doc, M.D. @DegenDocMD]

Not a self-control thing.

I wasn’t struggling to stop eating junk. I used Reta because I wanted fat down without gambling lean mass, and hunger biology isn’t just a mindset pep talk.

Training, protein, and the rest of the work still had to be there. It didn’t replace discipline.

Side effect I actually care about: A1c, lipids, and vitals are better than they’ve been in as long as I can remember. Reta is the real deal.

[Degen Doc, M.D. @DegenDocMD]

Just turned 52.

DEXA doesn’t care about my feelings.

June 2025:
22.4% body fat.
Hired a trainer.
Lifted hard.

8 months later (Feb 2026):
still 22.4%.
+2.2 lbs lean mass.
That’s all training bought me.

Then the stack started:
March — Retatrutide + CJC-1295/Ipamorelin
May — TRT
June — FLGR-242

Last 8 weeks (June 25 → Aug 25 DEXA):
+8.78 lbs lean
–1.51 lbs fat
While still on Reta.

Feb → now:
22.4% → 13.1% body fat
+14 lbs lean
–14.6 lbs fat

I was skeptical.
Multiple variables.
N=1.

But the lean-mass acceleration only showed up after FLGR-242.

Gaining ~1 lb of verified muscle per week on a GLP-1 is not a normal outcome.

@JayCampbell333 — credit where it’s due.

@BiohackerJake @n1after40 @NocturnalNelly @BalLongevity @GuerillaCh3mist @MattDChrist

[Jay Campbell @JayCampbell333]

If You Are a Serious User of Peptides and want to document your experience using @BioLongevityUSA FLGR-242:

Send me a PM with Subject Line: FLGR Experience.

I created a Telegram Group with some serious Vets who are going ALL IN.

Tracking, scans, before & afters.

Time to Prove FLGR-242 to the world for the doubters!

@BiohackerJake @n1after40 @NocturnalNelly @BalLongevity @GuerillaCh3mist @MattDChrist

[Degen Doc, M.D. @DegenDocMD]

@JamesBohanPitt Appreciate that. That hump was real — months of lifting and the BF% just sat there.

Glad you saw it click too. I’ll take 52 feeling like 42.

[Degen Doc, M.D. @DegenDocMD]

I wasn’t trying to starve it off.

I ate a lot of protein and kept carbs moderate.

I was more worried about losing muscle on Reta than I was about forcing a big deficit.

Fat loss was happening, but the goal was to protect lean mass — high protein, keep training hard, and not run calories into the ground just to make the scale move.

[Degen Doc, M.D. @DegenDocMD]

@JayCampbell333 @MattDChrist @BiohackerJake @BowTiedUM @VinnieSOfficial @danielkelly200 Appreciate you sharing @JayCampbell333

If I’m part of the scam now, at least the DEXA is a co-conspirator. 😅

[Degen Doc, M.D. @DegenDocMD]

Honest answer: I can’t call it proven truth or proven bullshit.

No clean human trials. Most logs, including mine, have TRT, training, and other peptides in the mix.

Mixed reviews make sense.

What I can say: I added FLGR-242 in June on top of Reta, CJC/IPA, and TRT. The next DEXA showed a bigger lean-mass jump than the months before it. That’s an n=1 observation, not a verdict.

If you try it, treat it as an experiment. Track with DEXA or at least consistent photos/measurements — not the scale. And don’t expect it to replace training, food, or testosterone.

[Degen Doc, M.D. @DegenDocMD]

@thefairtyna Appreciate it. 🙏 Grateful it showed up in the work and on the DEXA.

[Degen Doc, M.D. @DegenDocMD]

@JRMarco1911 Appreciate that. Recomp is a grind — the last few pounds of fat are always the meanest ones.

Feel great and grateful for the journey.

It’s progress over perfection… especially since I’ve already been told I need a prescription to start working legs. 😅

[Degen Doc, M.D. @DegenDocMD]

Both fair points.

TRT timing lines up, and I’m not pretending it doesn’t.

I never said FLGR replaced testosterone. I said the biggest lean-mass jump on paper happened after it was added to an existing stack. That’s an observation, not a controlled study.

Also agree on DEXA: lean mass ≠ pure muscle. Water, glycogen, and other FFM are in that number, and early TRT is known for that. Should’ve been more precise there.

Still an n=1. Training, Reta, secretagogues, TRT, and FLGR all in the mix. I’m not isolating a single cause.

[Degen Doc, M.D. @DegenDocMD]

@VinnieSOfficial Appreciate that — and appreciate your posts and the dedication you put into this space.

Discipline and the work were the base. The stack just gave it a louder signal.

Grateful it showed up on DEXA and not just in the mirror.

[Degen Doc, M.D. @DegenDocMD]

@joejfamous Never said it wasn’t the test.

Original post was pretty clear: TRT, Reta, CJC/IPA, training, then FLGR.

N=1. Multiple variables. I’m not running a trial.

Could be TRT doing most of the heavy lifting. That’s a fair read.

I’m not here to sell anybody anything.

[Degen Doc, M.D. @DegenDocMD]

@Position_AI Valid. 😅

Upper body answered the stack.

Legs are still waiting on prior authorization.

[Degen Doc, M.D. @DegenDocMD]

Appreciate that — and you’re not wrong that TRT is a big part of this.

May start means June–August is exactly when it should be showing up. I’m not trying to isolate FLGR as the only variable.

Training, Reta, CJC/IPA, and TRT were all in the mix.

What made me look twice was the rate: +5.7 lbs lean in the 8 weeks around starting TRT, then +8.8 lbs lean the next 8 weeks after adding FLGR — while still on Reta, when most people are fighting to keep muscle.

Could still be TRT maturing. Could be the stack. N=1 either way.

Appreciate the kind words.

[Degen Doc, M.D. @DegenDocMD]

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