Dié Tang

Genetics
Yale School of Medicine

[Dié Tang @deiko12433492]

https://t.co/5JG7FvulRV
中国农科院深圳基因组所左二伟课题组招聘博后
Postdoc position Erwei Zuo lab in shenzhen, AGIS, CAAS.

[Dié Tang @deiko12433492]

Congrats huang lab! Cool project just published on @nature. Releasing a sugar brake generates sweeter tomato without yield penalty. https://t.co/R717wZKSmZ

[Veera Rajagopal  @doctorveera]

A mind-blowing paper has come out today in @Nature

In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (https://t.co/Rk8oZJ0bUj).

Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome.

The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution.

Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell.

When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part.

The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival.

The conclusion of the paper is metaphorically a quote from the Jurassic Park movie:

“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (https://t.co/UlxRlb86CT)

https://t.co/zA9OAqSoAu

[Feng Zhang @zhangf]

Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in @Nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. https://t.co/aKLMMEBRkk

[Dié Tang @deiko12433492]

https://t.co/OuucYXEbT4

[Dié Tang @deiko12433492]

@OdedRechavi 😂😂😂

[Dié Tang @deiko12433492]

Live online class, as a speaker to introduce the U-potato Plan.☀️☀️

[Dié Tang @deiko12433492]

My article has been recommended on @FacultyOpinions https://t.co/T2OM1TRz8D

[Dié Tang @deiko12433492]

Tomato graph pangenome captures missing heritability and empowers breeding. Brilliant work by another group in our lab.

[Zhigui Bao 鲍志贵, zbao.bksy.social @zhigui_bao]

Our lab two pangenome paper just online back-to-back in @Nature. We use tomato graph pangenome to capture the missing heritability and guide tomato breeding. 1/n
https://t.co/l4x1K78oop

[Dié Tang @deiko12433492]

Impressive NEWS & VIEWS about our potato study by Juanita Gutiérrez-Valencia and Tanja Slotte.
Potato genomes pave the way to crop improvement https://t.co/V1v3gBnBec

[Dié Tang @deiko12433492]

The potato pan-genome epitomized the power of section-wide pan-genomics in dissecting tuber evolution, providing vital insights for hybrid potato improvement, and building a feasible framework of pan-genome studies that can be followed by other crops.
https://t.co/LmAWgnSEQb

[Nature Plants @NaturePlants]

A bit late, here is the cover for our August issue.

Full content available at https://t.co/LG4saB5izV

[Dié Tang @deiko12433492]

@zhigui_bao 妙啊

[Dié Tang @deiko12433492]

The new milestone of Upotato. So lucky to be involved in this exciting work!

[Cell @CellCellPress]

Online now! Genome design of potato inbred lines with high homozygosity enables the exploitation of heterosis in this tuber crop, and transforms potato breeding from a slow, non-accumulative mode into a fast iterative one.
#PlantScience 🌱🥔🧬
https://t.co/RVmMi7QPyC