@Sandate_C@LabThoma Big shoutout to the FMI Structural Biology platform - Simone Cavadini, Lukas Kater and Georg Kempf, and the amazing scientific environment provided by the FMI Basel @FMIscience
Excited to share that my first-author publication on the interplay of p53 with cofactors on chromatin is now online in @MolecularCell : https://t.co/bGcw3XOLRm
Nucleosomes filter cofactor access to p53 - USP7 binds whereas E6AP-E6 fails to form a complex.
Special thanks to co-author Colby Sandate @Sandate_C
for joining the p53 team and to all the contributing authors and the members of @LabThoma .Grateful to Nico for supporting this project and the fruitful collaboration with the Schübeler lab.
Our cells pack DNA into tiny bundles that hide important parts. Researchers at FMI and @EPFL found this packing affects how the cancer-fighting protein p53 works, revealing new insights into cancer. https://t.co/EBkleEz9HR
Excited to announce that I defended my PhD thesis on Monday!! Huge thanks to @FMIscience! Special thanks to my supervisor Nico (@LabThoma) and the members of my thesis committee, Dirk (@SchubelerLab) and Seth Rubin for all the support over the years!
Congratulations to Dr. Deyasini Chakraborty on defending her PhD thesis this week! 🥳🎓 Her research reveals how nucleosomes—structures of DNA wrapped around proteins—control the access of specific molecules to p53, a protein that helps regulate cell growth and prevent cancer.
We can now activate p53 Y220C by recruiting BRD4 to it with small molecule TRAP-1. This was a great collaboration with Gray lab and Attardi Lab @Stanford lead from @UniBonn@UniklinikBonn by @dpienkowska9 & @JanGerhartz.
https://t.co/kvAr0vHno8
Exciting Masters/PhD opportunities in Adelaide Australia, balancing creativity, excellence and inclusion!! Please join if your interested in Genomics and making a difference through research!! Please share with your networks!!!
Huge congratulations to Francesca Masoni on successfully defending her PhD thesis yesterday! Francesca worked towards better understanding the role of chromatin organization in gene regulation🧬Learn more about her research, visit: https://t.co/rMmCk1iHhi
I'm excited to share that I received a poster prize at the EMBL Transcription and Chromatin conference! Grateful for the opportunity and recognition!☺️ #EMBL2024
Wouldn’t it be great to test how individual transcription factors engage with their motif in the nucleus? We tried exactly that in a study lead by Ralph (@RalphSGrand) and Marco (@marco_heffler) now out in Molecular Cell https://t.co/eZanlaaKNQ. 1/7
Check out our latest review on Pioneer Transcription Factors (TFs) by @_M_Carminati, Luca Vecchia, and @lisastoos_ in Current Opinion in Structural Biology @COSB_CRSB! Read it here: https://t.co/ROxzoqnhTW