A 45-year-old man presents with progressive headache, gait instability, and cerebellar ataxia. Physical examination reveals a flesh-colored papule in the nasolabial region. Brain MRI demonstrates a cerebellar lesion with a characteristic laminated ("tiger-striped") appearance.
What is the most likely diagnosis, and which hereditary syndrome is it associated with?
A. Medulloblastoma — Gorlin syndrome
B. Hemangioblastoma — Von Hippel–Lindau syndrome
C. Lhermitte–Duclos disease — Cowden syndrome (PTEN mutation)
D. Pilocytic astrocytoma — Neurofibromatosis type 1
🩻 Case Study of the Week - Diagnosis time!
Erdheim-Chester disease.
The differential diagnosis includes Langerhans cell histiocytosis, Rosai-Dorfman disease, lymphoma, orbital pseudotumors, and neurosarcoidosis.
🔗 See all the case details, more images, and diagnosis: https://t.co/LKlT4FsGOt
#Radiology #RadEd #MedEd #RadiologyEducation #COW #CaseOfTheWeek
🩺Clinical & neuroimaging 🧠 clues to differentiate 🧩autoimmune encephalitis & its mimics🔎
Current opinions in Neurology 📖
10.1097/WCO.0000000000001489.
🧠 #SPINTweetorialWednesday
🧩 Case Challenge
A 2½-year-old child develops rapid neurological deterioration after a viral respiratory illness.
What's your diagnosis?
1/Sometimes the tiniest thing can be the biggest pain—that’s microvascular compression of the trigeminal nerve!
But seeing such a tiny finding can be hard!
Here’s a thread about how to look at the trigeminal nerve on MRI.
AJNR Clinical Practice is excited to share its newest articles!
Here is the featured article of the week:
"A Review of Chimeric Antigen Receptor T-Cell-Related Neurotoxicity"
https://t.co/0TOoBuGNMp
#AJNRClinicalPractice@theAJNR_EIC
Ravikumar et al: Suspect biotinidase deficiency in a pediatric patient presenting with LETM + optic neuritis, with progressive course, negative AQP4/MOG, high CSF lactate & MRI findings: fornix, mamillary bodies, and dorsal midbrain involvement @neuro_ian
10.4103/aian.aian_697_23
Big step forward for #MOGAD treatment!🚨
Our multicenter @JAMANeuro study shows that IL-6 receptor blockade (90% in Tocilizumab) markedly reduces relapses, achieving relapse-free outcomes comparable to high-dose IVIG (≥1g/kg/month).
If satralizumab gains approval for MOGAD, these data support #Tocilizumab as a widely available, lower-cost option thanks to biosimilars!
A great example of collaboration across the Americas🌎
#Neurology #MOG #NeuroTwitter
1/2 Case story 🧠
Headache, vomiting, confusion + fever. CT head normal.
MRI showed bilateral thalamic–basal ganglia signal abnormality with hippocampal involvement/enhancement.
Trap: fever + deep gray lesions can mimic viral encephalitis.
Excelente análisis de los recientes y notables avances contra la enfermedad de Alzheimer (EA).
Hacia un futuro donde la EA no solo sea tratable, sino también prevenible.
@CellCellPress https://t.co/ooggXeqz3P…
Multiple sclerosis is a chronic autoimmune disorder that affects the central nervous system, causing episodes of neurologic dysfunction and often gradual disease progression. Important advances in treatment have improved outcomes in patients with relapsing forms of multiple sclerosis. However, treatment options for progressive forms remain limited, which highlights the need for therapies that can prevent progression and promote myelin repair. Learn more: https://t.co/McH5l7urUG
Diagnostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in Differentiating Primary From Serious Secondary Headache https://t.co/AqCN5IPr1N
If you recognize this bedside sign, which diagnosis should immediately come to mind?
A. Stroke
B. Serotonin syndrome
C. Parkinson disease
D. Peripheral neuropathy