@cremieuxrecueil@gen0m1cs yes! courtsey of @DrSamuelBHume this graphic makes it clear, the lp(a) thresholds to join for the other trials as well as efficacy of the other drugs make it extremely worthwhile to wait.
a 70 vs 200 difference generates a profoundly different sample space
@Drlipid@nationallipid@foundationofnla@society_eas@ASPCardio@escardio@atherosociety my guess is the absolute drop just isnt big enough. burgess estimated ~100 mg/dl Lp(a( lowering to match a 39 mg/dl ldl drop. if you're enrolled at 70 its difficult to get there. imo try >250 mg/dl only, aim for 90% lowering, with endpoint being plaque volume
@arhamgrowthcap@CMichaelGibson they measured lp(a) directly iirc, look at the uk biobank. also one measurement is fine bc lp(a) is ~90% genetic and stable.
@ludwigABAP of ANY group he could pick he picked mathematicians (the ones that took it the best) lmfao.
tao has been using it and writing about it like a normal adult since the start n the labs are paying mathematicians by the hour to write problems because they ran out of hard ones
@cremieuxrecueil dimorphism is also just an ancestry marker tho & some populations have bigger sex differences in height on their own so ancestry taking half is the expected result
BUT hey it got through review and now its a good news for developing countries post 😊
@arabwizardry i donated blood for the first time thinking it was gonna be like a blood test and then they stuck the biggest metal needle ive ever seen into my arm