@jclinicalinvest Thanks for promoting our work! We are following this primary result to investigate potential biology for therapeutic interventions. Stay tuned!
The FNDC4 gene has been associated with #alcohol use disorder risk and treatment response through independent genome-wide association studies.
Here, Richard M. Weinshilboum, Duan Liu @dliu55 & team @MayoClinic report on neural organoids from WT and FNDC4 gene deficiency, finding the FNDC4 gene affects alcohol use disorder risk and drug treatment outcomes by altering #neurogenesis: https://t.co/bLJPn5MjDC
The figure represents electrical activities of WT and FNDC4-KO neural organoids.
The FNDC4 gene has been associated with #alcohol use disorder risk and treatment response through independent genome-wide association studies.
Here, Richard M. Weinshilboum, Duan Liu @dliu55 & team @MayoClinic report on neural organoids from WT and FNDC4 gene deficiency, finding the FNDC4 gene affects alcohol use disorder risk and drug treatment outcomes by altering #neurogenesis: https://t.co/bLJPn5MjDC
The figure represents electrical activities of WT and FNDC4-KO neural organoids.
A big week for genetics, omics, and precision medicine — so many exciting reads🧬
1⃣Circadian gene expression regulation by rhythmic genetic variants
2⃣In vivo tracking of ASO delivery in the brain
3⃣eQTL mapping vs. CRSPRi screening for detecting causal genes in GWAS loci
4⃣Real-time assessment of coronary plaque biocomposition
5⃣Largest GWASs for eating disorders
6⃣Cross-platform proteomics comparisons
7⃣Serial single-cell RNAseq of glioblastoma
8⃣Scaling colocalization to multiple molQTLs and GWAS datasets
🏈 12 DAYS OF GIVEAWAYS 🏈
Thanks to our friends from the @Vikings, we are giving away a Vikings Fan Pack including a Harrison Smith autographed football, a Vikings backpack, and more!
Repost and follow us for your chance to win!
Sweepstakes ends December 13 at 11:59 pm.
Our newly approved strategic initiative, Bold. Forward. Unbound. in Rochester, will transform healthcare at Mayo Clinic and beyond. Read more: https://t.co/oub12q6d1S #BoldForwardUnbound
Liu et al identifies a genetic variant in a #GWAS in #DCM associated with myocardial recovery that decreases #CDCP1 expression & human cardiac #fibroblast proliferation. Learn more at https://t.co/BnKJdgCZMw
@diliu55 @nl_pereira@rcstarling @NV_Murthy@thanhthanhphd
Our study on CDCP1 and Myocardial Recovery in Dilated Cardiomyopathy (DCM) is "issued" in @CircRes today. Thanks to Dr. Pereira @nl_pereira for his leadership and his trust allowing me participated in this exiciting research project. https://t.co/v94zGohoWH
First study that identifies a novel, genetic mediator for improvement in LVEF in DCM that modulates cardiac fibrosis. Could be an important target to improve LVEF and fibrosis. So proud of my lab and @dliu55. Grateful to @MayoClinicCIM@MayoClinicCV and my worldwide collaborators
Congrats Sophie on winning the overall Arbor Day poster contest. We planted a tree today in recognition of your beautiful artwork. Thanks ArborWise for the donation!
Glad to see our work on the glucocorticoids-mediated PGx-eQTLs is online now. Led by our brilliant student @thanhthanhphd, these extensive genomic studies unveiled "silent" genetic variants contribute to a broad-range but glucocorticoid-related diseases. https://t.co/QIQ8OXVNDI
Here is our recent study on glucocorticoids-mediated APA, led by @thanhthanhphd . We found glucocorticoids can regulate RNA poly(A) site selection in immune cells, a mechanism which might play a role in coronavirus infections. @ASCPTjournals https://t.co/rIF84ywkAq
Super excited to share our paper published today in @Nature, where we discover the primary role of ADAR RNA editing in inflammatory diseases. Huge thanks to Mike @mikegloud, Jonathan @jkpritch, Stephen @sbmontgom, Billy @RNAedit and other collaborators. https://t.co/Bz7VIMk2rg
Led by my colleague Dr. Zhang, our team have characterized the function of hundreds missense variants in the ACE2 and TMPRSS2 genes. Potentially explained why COVID-19 symptoms are more severer in some individuals but not others. https://t.co/D3HBzVcaCG