Chenoweth Lab

Student-run twitter account for the Chenoweth Lab at University of Pennsylvannia. Chemical Tools, Fluorophores, Nucleic Acid Binding Molecules, Collagen.

[Rachel Lackner @rachlack]

Yesterday I successfully defended my PhD @PennChemistry. Eternally grateful for the people who made these last 5 years a little easier, many of whom tuned in both virtually and IRL. I dreamed of this day so many times, never knowing how full my heart would feel.

[Chenoweth Lab @DMChenowethLab]

Check out the group's latest paper out of our collaboration with @molandergroup ASAP @JOC_OL. Congrats Mike and Mo! @PennChemistry
https://t.co/0I0RDNEvkN

[Matthew C. Good @buenoscience]

Thanks to all the fantastic current and former members of my lab whose efforts made this possible! Excited about where we are headed next.

[Chenoweth Lab @DMChenowethLab]

Our latest work is officially up at @ChemBioChem! @PennChemistry

[ChemBioChem @ChemBioChem]

A General Strategy for the Design and Evaluation of Heterobifunctional Tools: Applications to Protein Localization and Phase Separation (Zhang, Chenoweth) @lab_zhang @CarnegieMellon @DMChenowethLab
https://t.co/e80KdRs5cI

[Rachel Lackner @rachlack]

Today was my last lab day before I move to NYC. I’ll be back to defend my thesis but until then I’ll miss my friends in the @DMChenowethLab and in @PennChemistry. I won’t miss the vagelos mice tho….

[Chenoweth Lab @DMChenowethLab]

Check out the latest paper from the group! In collaboration with @lab_zhang, we developed an assay to study the "linkerology" of chemical dimerizers and applied a new tool to control phase separation.

[Huaiying Zhang @lab_zhang]

If you are interested in chemical biology, check out our new paper in collaboration with Chenoweth lab where we optimized the linker for our TMP-Halo system for fast dimerization and applied it to control phase separation in cells. https://t.co/raOUd6oGR4

[Huaiying Zhang @lab_zhang]

If you are interested in chemical biology, check out our new paper in collaboration with Chenoweth lab where we optimized the linker for our TMP-Halo system for fast dimerization and applied it to control phase separation in cells. https://t.co/raOUd6oGR4

[Nick Porter @NJP_Chem]

Thrilled to share this work! We engineered a heme enzyme to activate diazirines, giving us access to donor-subsitituted carbenes in biocatalysis. Many thanks to @francesarnold and our collaborators Emma Danelius and @gonenlab.

https://t.co/GTh2hCliUV

[Chenoweth Lab @DMChenowethLab]

Congratulations to Sam, @MicelleYoucelle, and Pengfei on their recent paper “Rules for Aza-Glycine Incorporation in Collagen Peptides” @ChemicalScience Also, we love Sam’s clever homage to The Price is Right in the outside cover art! https://t.co/JUnSPu9lBH

[Chenoweth Lab @DMChenowethLab]

Big congratulations to @danielwuhoo as he passed his dissertation defense and will be an alumnus from @PennChemistry! Dr. Daniel Wu will be joining @GSKUS as an Investigator in Chem Bio. We’re all excited for you and your future endeavors! 👏🙌

[Chenoweth Lab @DMChenowethLab]

Keep an eye out for some really cool probes made by our very own @ChrisJScience! 🧪🔥🔥🔥

[Christopher Johnny @ChrisJScience]

Hello! Rising third year @PennChemistry in the @DMChenowethLab here. I synthesize photoconvertible fluorescent molecules for spatiotemporal imaging and tracking of cells and cellular cargo. I’m an aspiring Chemical Biology P.I. and entrepreneur. #BlackinChem #BlackinChemRollCall

[Chenoweth Lab @DMChenowethLab]

Here’s the first https://t.co/5NFfFhepol

[Chenoweth Lab @DMChenowethLab]

Learn how to shine bright like a fluorophore designed by @JoomyungJun. Vicky’s 2nd pub after leaving @PennChemistry 😮

[Chenoweth Lab @DMChenowethLab]

Your synthesis of that many azGly containing collagen peptides better be pretty good if you’re making that many! See our optimized SPPS methods (link here) https://t.co/GFH8iSfQ9L

[Chenoweth Lab @DMChenowethLab]

Rules for the Design of Aza-Glycine Stabilized Triple-Helical Collagen Peptides - A tour de force effort synthesizing ~46 peptides with 2 high res collagen xstal structures to complete the design rules for azGly incorporation by Sam Melton and colleagues https://t.co/9YsDlqIZvd

[Chenoweth Lab @DMChenowethLab]

~90 peptides if u include the sister paper (linked below). That’s a lot of reserved CD and HPLC time! https://t.co/bIQrrWxinC

[Chenoweth Lab @DMChenowethLab]

Congrats Rachel and @JoomyungJun

[Jen Heemstra @jenheemstra]

.@angew_chem the Chemistry field will remember how you handled this. You published a paper that literally had “diversity of workforce” labeled as a negative influence on our field. This is not a moment to respond with the equivalent of “oops, we need to fix some typos.”

[ChristiansonLaboratory @ChristiansonLab]

Congrats to group alumnus Yang Hai @yanghaiBioChem - our 2016 paper describing the crystal structure of HDAC6 was highlighted as one of the Greatest Hits in the past five years of @nchembio! See "Best Partnership": https://t.co/x2uK6Fd0bN

[Chemical Communications @ChemCommun]

Have you read 'Rosetta custom score functions accurately predict ΔΔG of mutations at protein–protein interfaces using machine learning'?
It's the latest Comm from John J. Ferrie & E. James Petersson et al. @PennChemistry
👉🔗 https://t.co/6YcV2vrUH1