New paper @JCellBiol! We found a new regulator of p62 phase separation, autophagy, and antioxidant signaling — it is an E3 ligase adaptor called SHKBP1 but the effect is via direct p62 binding, not ubiquitination. Congrats to Lin Luan & team!
https://t.co/c8soXJaZ0q
How to determine the proteome of cellular compartments?
We established a method to do just that, published in @elife: SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection https://t.co/eudW9kRIUi
Goodbye Dresden and Pillnitz! Had a blast @mpicbg and the ESBOC annual bioorganic chemistry meeting — a #lipidtime#chembio 1-2 👊. Thanks to @nadlerlab and Ben Schumann for the invitation, great to see @FiedlerLab@FedorovaLab and other friends!
Our May issue is live!
https://t.co/i8r9ZUPpXi
The cover image depicts the vulnerability of the non-transcribed strand of genes to oxidized guanines and abasic sites
A new CRISPR-based genetic toolkit enables genome-wide, single-cell gene analysis in fruit flies.
This will speed up gene discovery and reveal insights into brain function, development, and disease. Developed by researchers at @Cornell.
Read more: https://t.co/hdA6LD1qye
The Booker Lab at the University of Pennsylvania, in Philadelphia, and HHMI is searching for a lab manager. If interested, please apply at the HHMI link below.https://t.co/wFjZnkired
Special day @CornellChem: welcoming back PhD alum Xiaoyu Zhang (Hening Lin lab) from @NUChemistry for a phenomenal seminar on targeted protein degradation and chemical immunology!
Methods in Enzymology, Volumes 726-728: Lipids & Membranes
Vol 726: Detection by Imaging & Lipidomics https://t.co/3SiJ0gD0rI
Vol 727: Dynamics & Interorganelle Transport https://t.co/nmVHici7FB
Vol 728: Metabolism, Lipidation, & Lipid-Protein Interactions: coming soon!
I've been leading a big project at Methods in Enzymology over the past year: editing back-to-back-to-back volumes describing the latest advances in methods for studying lipids and membranes — thank you to the 50 #lipidtime luminaries who contributed the 51 chapters! Details 👇
A Postdoctoral Associate position is available in the Roeder Laboratory at Cornell University in Ithaca, NY with a focus on researching Polyploidy. Apply by March 1. Please spread the word. https://t.co/NkKgAEb1uj
Too much data, too little thinking.
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@RMedzhitov@YaleIBIO
https://t.co/d3Q2Slp0hx
Lin Luan, Jeremy Baskin @basktastic et al. @weillinstitute@CornellChem identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. https://t.co/ntD8VbAuSy
#CellSignaling
Check out our new chapter in Methods in Enzymology on inhibition of #sterol protein function! Here @HoganBryceRoge1, @Laura_dta and @tomeveriss describe in detail our assay cascade to identify inhibitors of sterol transport proteins. (1/2) https://t.co/3QDFBq5bLe
It was fun writing this book chapter on methods to trace #lipid metabolism.
Congrats to Alec and Helene! Thanks to @basktastic for the invitation to contribute this chapter. #lipidtime@OHSUNews
https://t.co/HwxLpEo0se
Membrane editing with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles
https://t.co/kCOZ8NWfB5