Prof. Michael Lin

Stanford Neurobiology and Bioengineering
Precision molecular design / synbiochem.
Also @michaelzlin

[Arda Göreci @ArdaGoreci]

Today, we are launching our research blog!

We’ll use it for technical notes from our work building tools for enzyme and biomolecular design.

Our first post is about The Unreasonable Redundancy of Nature's Protein Folds.

TLDR: Please don't fold more sequences (1/n)

[Prof. Michael Lin @MichaelLinLab]

@JiannisTax Thanks Jiannis!

[Prof. Michael Lin @MichaelLinLab]

Excited to announce a powerful new one-two punch for voltage imaging from our lab and collaborators! In two new preprints, we introduce ASAP6c for high-throughput population spike-recording, and ASAP7yfor deep, subthreshold 2P imaging.
🧵 1/14

[Prof. Michael Lin @MichaelLinLab]

@KarlDeisseroth @smoolee85 @yusterafa @lisa_giocomo @StanfordBrain @NIH_NINDS @NIH_Innovates @USBrainAlliance Oh, and to clarify,

Odd ASAPs (3/5/7) are negative (+ΔV ➔ –ΔF)
Even ASAPs (4/6) are positive (+ΔV ➔ +ΔF)

⊕ ASAP6c is ideal for APs: low baseline F₀ means high ΔF/F₀, which relates linearly to SNR

For ⊖ ASAP7y, high F₀ and high slope makes SNR as high as possible for SPs

[Prof. Michael Lin @MichaelLinLab]

@KarlDeisseroth @smoolee85 @yusterafa @lisa_giocomo All made possible by @StanfordBrain
@NIH_NINDS NIMH NIGMS @NIH_Innovates and @USBrainAlliance (#BRAINInitiative) supporting "new technologies to explore how the brain’s cells and circuits interact at the speed of thought"

[Karl Deisseroth @KarlDeisseroth]

Yes! ASAP7y works well with both conformal immersion microscopy (CIM):
https://t.co/inwrH1oCCd
and other widefield methods including tandem lens macroscopy:
https://t.co/hrIcONFQ8p
helping to unveil fast dynamics (see video).
Congrats to the ASAP team:
https://t.co/zv1tG0CNUM