Assistant Prof @MITChemE ; mom^4 + wife; enjoys building cell-fate circuits, exploring dna topology, reprogramming the living world, and soccer; soli gloria deo
Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)
Nifty work on plasmid chromatinization from @stergachislab !
"plasmids are indeed capable of recapitulating nuclear genome-encoded chromatin architectures, ... However, plasmids consistently adopt a heterogeneous and incomplete chromatin architecture relative to nuclear-encoded chromatin fibers, and surrounding sequence context plays an integral role in modulating whether a plasmid-encoded regulatory element will recapitulate nuclear genome-encoded chromatin architectures."
Excited to share our preprint on autonomous feedback control in synthetic receptor systems.
We engineered a miRNA-based negative feedback circuit where synNotch activation drives expression of a synthetic miRNA that represses the receptor itself.
Preprint: https://t.co/JIEP59vjjb
@mbeisen Broke: all vertebrates evolved from fish.
Woke: fish evolved from amphibi-birds.
Bespoke: Viruses evolved from nematodes.
Galaxy-brain-oke: Drosophila is a plant.
🚨What if we could reliably program macrophage polarization state?🚨
https://t.co/6qGxuHptQq
Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)
Want the precision and control of RNA devices but not sure how to engineer your lenti to deliver them?
🚨new pre-print from @kaseyslove🚨
hint: syntax matters! 👇
Interested in genetically encodable inhibitors of your favorite biomolecular condensate? Excited to announce our latest work, w/ @jibin_sadasivan, @GeneWeiLiLab, & @LindsayCase19, on protein fragments as generalizable regulators of phase separation. (1/n)
https://t.co/6IMkrTP3ZQ