Katie Galloway

Assistant Prof @MITChemE ; mom^4 + wife; enjoys building cell-fate circuits, exploring dna topology, reprogramming the living world, and soccer; soli gloria deo

[Katie Galloway @GallowayLabMIT]

Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)

[Katie Galloway @GallowayLabMIT]

@arjunrajlab Lol

[Katie Galloway @GallowayLabMIT]

@lpachter Atlantes? pretty sure that's a vacation resort in the Bahamas

[Katie Galloway @GallowayLabMIT]

it is Atlases all the way down

[Arjun Raj @arjunrajlab]

Okay, I made an Atlas of Cell Atlases. Will post code later.

[WBZ | CBS News Boston @wbz]

Meteor explodes off Massachusetts coast, causing loud boom, meteorologist confirms https://t.co/ymz33C6poU

[Michael Baym @baym]

Did anyone else in Cambridge/Boston just hear what sounded like a loud boom and rumble? Like an explosion or large object falling?

[Katie Galloway @GallowayLabMIT]

@baym what was it?

[Katie Galloway @GallowayLabMIT]

Beautiful moon over Lexington

[Katie Galloway @GallowayLabMIT]

@bloodgenes Thanks, Vijay!

[Katie Galloway @GallowayLabMIT]

Graduation and hooding for these three Galloway Lab PhDs! Congrats, Brittany, Sneha, and Chris! Excelsior!

[Katie Galloway @GallowayLabMIT]

Nifty work on plasmid chromatinization from @stergachislab !

"plasmids are indeed capable of recapitulating nuclear genome-encoded chromatin architectures, ... However, plasmids consistently adopt a heterogeneous and incomplete chromatin architecture relative to nuclear-encoded chromatin fibers, and surrounding sequence context plays an integral role in modulating whether a plasmid-encoded regulatory element will recapitulate nuclear genome-encoded chromatin architectures."

[Molecular Cell @MolecularCell]

Online Now: Chromatin architectures underlying plasmid-based assays for regulatory variant effects https://t.co/uiYvhgROas

[Tom de Greef @tfadgreef]

Excited to share our preprint on autonomous feedback control in synthetic receptor systems.
We engineered a miRNA-based negative feedback circuit where synNotch activation drives expression of a synthetic miRNA that represses the receptor itself.
Preprint: https://t.co/JIEP59vjjb

[Katie Galloway @GallowayLabMIT]

@baym Pseudonymity brings our the worst in folks. I'm sorry 😞

[Katie Galloway @GallowayLabMIT]

In case you're wondering if science twitter is dead, here it lives 😂

[Professor Booty PhD @ProfBootyPhD]

@mbeisen Broke: all vertebrates evolved from fish.

Woke: fish evolved from amphibi-birds.

Bespoke: Viruses evolved from nematodes.

Galaxy-brain-oke: Drosophila is a plant.

[Kyle G Daniels @ScienceKyle]

🚨What if we could reliably program macrophage polarization state?🚨

https://t.co/6qGxuHptQq

Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)

[Katie Galloway @GallowayLabMIT]

Want the precision and control of RNA devices but not sure how to engineer your lenti to deliver them?

🚨new pre-print from @kaseyslove🚨
hint: syntax matters! 👇

[bioRxiv Synthetic Biology @bioRxiv_synbio]

Engineering high-titer lentiviral vectors for robust expression of RNA-based gene circuits https://t.co/W1Cd4cdjQC #biorxiv_synbio

[Andrew Savinov @bioSavinov]

Interested in genetically encodable inhibitors of your favorite biomolecular condensate? Excited to announce our latest work, w/ @jibin_sadasivan, @GeneWeiLiLab, & @LindsayCase19, on protein fragments as generalizable regulators of phase separation. (1/n)
https://t.co/6IMkrTP3ZQ

[Katie Galloway @GallowayLabMIT]

Nifty supercoiling work looking at RNAP and folding of bacterial plasmids into plectonemes!

[Molecular Cell @MolecularCell]

Online Now: Apical localization of RNA polymerases modulates transcription dynamics and supercoiling domains revealed by cryo-ET https://t.co/INuW5n37av