Mo Khalil

Prof. @ Harvard University, Broad Institute, and Wyss Institute. Understanding the natural world by building a synthetic one. website:

[Mo Khalil @MoKhalilLab]

Attn eVOLVER users & enthusiasts. 2 BIG developments!

1) New open-source eVOLVER wiki, which will be a hub for guides and documentation: https://t.co/1RkGpYgltq

2) eVOLVER software version 2.0 is now available! Read about the new features on the forum: https://t.co/K2oHCngHSG

[Mo Khalil @MoKhalilLab]

Lovely study by the team, showing how TF specificity emerges from weak and multivalent interactions! (a property we've been obsessed with modeling, designing and engineering in cells 😍)

[Tjian + Darzacq Group @TjianDarzacq]

Out now in Science! Our new study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.🧵
https://t.co/w5mYmh4I1G

[Mo Khalil @MoKhalilLab]

🚨 An exciting frontier is bringing synthetic biology to MULTIcellular systems. To effectively engineer them, we need design principles. What are the benefits of group formation? What are the costs? See our new preprint led by @HeidiKlumpe to learn more!👇
https://t.co/Yc51Dx2KAf

[Heidi Klumpe @HeidiKlumpe]

The preprint from my work @MoKhalilLab and @DunlopLab at BU is out on bioRxiv! As new tools come online to engineer multicellularity, we asked: how does sticking cells together into larger groups affect their fitness and function?

[Lior Pachter @lpachter]

Sean Eddy developed profile HMMs in the 1990s, ultimately leading to his HMMER project, which includes JackHMMER that AlphaFold relies on. Apparently his work has been determined to be "of absolutely no value to the US taxpayer". Obviously that's not true.
https://t.co/LZgihGGnUk

[Mo Khalil @MoKhalilLab]

@grocklin Thank you, Gabe 🙏. And huge congrats to you and the team on the big, recent work!

[Mo Khalil @MoKhalilLab]

HONORED to receive the Kuwait Prize! A testament to the achievements and hard work of Khalil lab members past and present. It’s an honor to be recognized as a scientist, and especially meaningful to celebrate my background as a Palestinian-Jordanian 🙏
https://t.co/4Xw3Y6axgP

[Mo Khalil @MoKhalilLab]

@chang_c_liu Thank you, Chang 🙏 I treasure our collaboration and friendship.

[Gabriel Rocklin @grocklin]

Happy to share this in its published form! More than any project I've worked on, this was a huge team effort, so thank you so much to that team! Especially @ajrferrari https://t.co/SIRHWKYdlH

[Mo Khalil @MoKhalilLab]

@ProfTomEllis Thanks so much, Tom 🙏

[Mo Khalil @MoKhalilLab]

@arjunrajlab Aww, thanks so much, Arjun 🙏

[Mo Khalil @MoKhalilLab]

@bloodgenes Thanks so much, Vijay! The feeling is mutual — very excited to work with!

[Mo Khalil @MoKhalilLab]

@JenniferALewis1 Thank you, Jennifer 🙏🙏

[Mo Khalil @MoKhalilLab]

@baym Thanks, Michael 🙏

[Mo Khalil @MoKhalilLab]

@mkoeris Thank you, Mike!

[Sternberg Lab @SternbergLab]

1/9 New preprint from the Sternberg Lab in collaboration with the Nishimasu Lab! We uncover how the DRT3 antiphage immune system pairs two reverse transcriptases, one RNA-templated and one protein-templated, to build a double-stranded DNA effector. https://t.co/KvouqrCWDW

[Evan Weber @EvanWeberPhD]

The manufacturing step for CAR T has always been ripe for innovation.

Here, Gattinoni and Kochenderfer groups show that pharmacologic enrichment of memory-like Tscm cells boosts CD19 CAR T expansion and durable persistence in patients, even at low doses!

https://t.co/Buxs49cJic

[Vijay Sankaran @bloodgenes]

🚨 Excited to share a new paper in Cell! Human genetics led us to HOTSCRAMBL, a HOXA-locus lncRNA that regulates 🩸#stemcell self-renewal and HOXA9 splicing, with implications for AML.

Amazing work by @lvchosen1 with @silvirouskin, @Armstrong_dfci, and many more!

https://t.co/Kralk3tmzg

[Barkai Lab @BarkaiLab]

How do transcription factors (TFs) that recognize the same DNA motif end up binding different places in the genome? 🧬

We're excited to show you how we tackle this question in our new bioRxiv pre-print!

https://t.co/rwjTaCekCR

[Harris Wang @harriswangnyc]

1/ Excited to share our new paper in Science: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” @ColumbiaSysBio @ColumbiaBME @Columbia
https://t.co/ZT3Ygw9tiG 🦠🧬🛠️🖥️💥

[American Institute of Chemical Engineers (AIChE) @ChEnected]

Breakthroughs in mammalian synthetic biology happen when bold ideas meet the right audience. Could your research define the next frontier of medicine? Submit your abstract now: https://t.co/Izoc5o2OP7 #mSBW2026 #SyntheticBiology #MammalianSystems #CallForAbstracts

[Polly Fordyce @fordycelab]

New preprint alert - 5 years in the making! Using high-throughput microfluidic enzyme kinetics, we profiled 190 clinical variants of SHP2, a phosphatase linked to developmental disorders & cancer (1/8)
https://t.co/wSO3Uv2gia

@Stanford_ChEMH, @czbiohub, @bioe_stanford