Attn eVOLVER users & enthusiasts. 2 BIG developments!
1) New open-source eVOLVER wiki, which will be a hub for guides and documentation: https://t.co/1RkGpYgltq
2) eVOLVER software version 2.0 is now available! Read about the new features on the forum: https://t.co/K2oHCngHSG
Lovely study by the team, showing how TF specificity emerges from weak and multivalent interactions! (a property we've been obsessed with modeling, designing and engineering in cells ๐)
Out now in Science! Our new study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.๐งต
https://t.co/w5mYmh4I1G
๐จ An exciting frontier is bringing synthetic biology to MULTIcellular systems. To effectively engineer them, we need design principles. What are the benefits of group formation? What are the costs? See our new preprint led by @HeidiKlumpe to learn more!๐
https://t.co/Yc51Dx2KAf
The preprint from my work @MoKhalilLab and @DunlopLab at BU is out on bioRxiv! As new tools come online to engineer multicellularity, we asked: how does sticking cells together into larger groups affect their fitness and function?
Sean Eddy developed profile HMMs in the 1990s, ultimately leading to his HMMER project, which includes JackHMMER that AlphaFold relies on. Apparently his work has been determined to be "of absolutely no value to the US taxpayer". Obviously that's not true.
https://t.co/LZgihGGnUk
HONORED to receive the Kuwait Prize! A testament to the achievements and hard work of Khalil lab members past and present. Itโs an honor to be recognized as a scientist, and especially meaningful to celebrate my background as a Palestinian-Jordanian ๐
https://t.co/4Xw3Y6axgP
Happy to share this in its published form! More than any project I've worked on, this was a huge team effort, so thank you so much to that team! Especially @ajrferrari https://t.co/SIRHWKYdlH
1/9 New preprint from the Sternberg Lab in collaboration with the Nishimasu Lab! We uncover how the DRT3 antiphage immune system pairs two reverse transcriptases, one RNA-templated and one protein-templated, to build a double-stranded DNA effector. https://t.co/KvouqrCWDW
The manufacturing step for CAR T has always been ripe for innovation.
Here, Gattinoni and Kochenderfer groups show that pharmacologic enrichment of memory-like Tscm cells boosts CD19 CAR T expansion and durable persistence in patients, even at low doses!
https://t.co/Buxs49cJic
๐จ Excited to share a new paper in Cell! Human genetics led us to HOTSCRAMBL, a HOXA-locus lncRNA that regulates ๐ฉธ#stemcell self-renewal and HOXA9 splicing, with implications for AML.
Amazing work by @lvchosen1 with @silvirouskin, @Armstrong_dfci, and many more!
https://t.co/Kralk3tmzg
How do transcription factors (TFs) that recognize the same DNA motif end up binding different places in the genome? ๐งฌ
We're excited to show you how we tackle this question in our new bioRxiv pre-print!
https://t.co/rwjTaCekCR
1/ Excited to share our new paper in Science: โToward life with a 19-amino acid alphabet through generative artificial intelligence design.โ @ColumbiaSysBio@ColumbiaBME@Columbia
https://t.co/ZT3Ygw9tiG ๐ฆ ๐งฌ๐ ๏ธ๐ฅ๏ธ๐ฅ
Breakthroughs in mammalian synthetic biology happen when bold ideas meet the right audience. Could your research define the next frontier of medicine? Submit your abstract now: https://t.co/Izoc5o2OP7 #mSBW2026#SyntheticBiology#MammalianSystems#CallForAbstracts
New preprint alert - 5 years in the making! Using high-throughput microfluidic enzyme kinetics, we profiled 190 clinical variants of SHP2, a phosphatase linked to developmental disorders & cancer (1/8)
https://t.co/wSO3Uv2gia
@Stanford_ChEMH, @czbiohub, @bioe_stanford