Kyle G Daniels

Assistant Professor @Stanford University Genetics. Synthetic Biologist // Real Human 🧬 🔬 💻 🏳️‍🌈 🏊🏾‍♂️

[Kyle G Daniels @ScienceKyle]

🚨What if we could reliably program macrophage polarization state?🚨

https://t.co/6qGxuHptQq

Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)

[Michael Lin, MD PhD 🧬 @michaelzlin]

PSA: get your flu shot now if you haven't already

Using last year's flu trends as a template, from today we expect infection rates to double every 1.5 weeks, peaking ~2 months from now.

After vax, immunity takes 1.5 weeks to kick in, peaks at 1-2 months, decays after 3 months.

[Kyle G Daniels @ScienceKyle]

@michaelzlin Oooh thanks!

[Jason Sheltzer @JSheltzer]

Pleased to share my lab’s new manuscript integrating genomics, drug development, cell biology, and mouse modeling to comprehensively evaluate the cyclin-dependent kinase CDK11 as a drug target in cancer.

[ElowitzLab @ElowitzLab]

Check out this exciting synthetic biology opportunity — designing multicellular circuits at the Allen Institute for Cell Science.

https://t.co/bzZd3fkQKs

[Kortemme Lab @KortemmeLab]

We’re excited to share our new perspective in @MolecularCell on designing programmable biological behavior! (1/3)

https://t.co/wde7ovvxXO

[Heather L Gornik @heatherlgornik]

As an Editor, in past ~6mo, we are receiving an avalanche of unsolicited review articles (“scoping” “systematic”, narrative, NOS) on topics and ?s NO ONE EVER has asked and clearly with heavy AI lift. Even the cover letters all read the same…alarming and sad. #publishing

[Anshul Kundaje @anshulkundaje]

1. COMBINATORIAL STOICHIOMETRY: Regulators do not act alone, there is redundancy, competition, synergy & feedback. Knocking them down one by one is insufficient to learn the spectrum of regulatory effects (which is essential to generalize). 2/

[Daniel Keedy @DanielKeedy]

The Keedy Lab at the CUNY ASRC in NYC is looking for a postdoc! Our lab uses avant-garde structural biology experiments and computational analyses to reveal conformational ensembles that underlie biological function. See attached flyer and https://t.co/GA9rqzPOp1. Please share!

[Dana-Farber News @DanaFarberNews]

Congratulations to @DanaFarber’s @nickpolizzi_ and @XinGu0317 who have received New Innovator Awards from the @NIH High-Risk, High-Reward Research program which supports early career investigators pursuing highly innovative research with potential for broad impact on biomedical and behavioral science. @DFCI_CancerBio

Read more: https://t.co/jZ0YLbv6CA

[Kyle G Daniels @ScienceKyle]

@XinGu0317 🎉

[Kyle G Daniels @ScienceKyle]

@MoKhalilLab @NIH Congrats, Mo!

[Mo Khalil @MoKhalilLab]

Exciting news! Our team was selected to receive the @NIH Director's Pioneer Award!
Our project asks: can we make a tool to perturb & map proteome function at scale, to do “do for proteins what CRISPR has done for genes"?

[Patrick Collison @patrickc]

We're hosting a small event to discuss the latest advances in AI and biology this Friday evening, featuring @arcinstitute researchers and others. Apply if interested! https://t.co/Esdvf4td1F

[kaleid ⛓️ @radi0lover]

getting old is insane. we found out last week my grandpa has cancer and the doctor was just like "he's 90 years old, he says it's not bothering him, we're just gonna leave it be, otherwise we'd make him miserable" and like. yeah he's kinda right

[Kyle G Daniels @ScienceKyle]

@ealarkin7 @stephanie_mul I read your post and then was very frustrated to learn that Valius is at the cutting-edge on diagnostics yet so behind on treating patients

[Rizwan Romee @romeerizwan]

Delighted to share our paper led by Dr Mubin Tarannum in my lab #romeelab @DanaFarber showing how spatially restricted IL-12 in CAR NK cells leads to markedly enhanced tumor responses beating IL-15 and mediated through car and IL-12 signaling synergy through mTORC1

[Livnat Jerby @LivnatJerby]

Excited to share DR-GEM, a self-supervised computational framework for dimensionality reduction and clustering, and its application to single-cell and spatial transcriptomics. https://t.co/PaJ1VrPaXn
Congrats to the team! @christineyyeh, who spearheaded this study, @DixianZhu, and @minwsun.

Here is a quick overview of the paper 👇 (1/11)

[Cell @CellCellPress]

In the latest issue! Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function https://t.co/njg3ufc2RJ

[UCSF Neurosurgery @NeurosurgUCSF]

In a new @ScienceAdvances study, @SanjeevHerr, Shawn Hervey-Jumper, MD, @ToddCHollon, & their colleagues at @UCSF & @umichneuro present an AI model that predicts where #glioblastoma is likely to recur, paving the way for earlier, targeted interventions. https://t.co/ga5fxqBv3k