Douglas Cannie

[HFAPresident @HFA_President]

Should we rethink genetic testing in older #DCM patients?🧬

In this cohort of 686 patients:
📍median age 50, 62.1% male
📍1 in 5 patients over 55 years of age were
genotype-positive
📍30% of genotype-positive patients >55 years had high-risk genotypes
📍Similar risk of ventricular arrhythmias & end-stage HF vs younger patients

📚Read more in #EJHF @EJHFEiC :
https://t.co/uRfE0NGH4G

#HeartFailure #Cardiomyopathy #Genetics
@escardio @MarcoMetra @dougcannie @ath_bakalakos @ESC_Journals

[Douglas Cannie @dougcannie]

@CompleatQuiz we won last week but alas didn’t receive our voucher. Can you message me to resend please?

[Professor Kevin Mills @Prof_K_Mills]

Front page of The Times this morning for our lab, describing our use of artificial intelligence & panels of biomarkers to create new predictive test for Parkinson's Disease.
It is an absolute privilege to work with the superb clinicians and scientists at UCL.
#ParkinsonsDisease

[Douglas Cannie @dougcannie]

@soph_cash @nottmhospitals Yes! Great news! Congratulations, Sophia!

[EHJ Editor-in-Chief @ehj_ed]

A deep dive into cardiac complications in Emery Dreifuss muscular dystrophy!

https://t.co/xmei80uweR

#ventricular #arrhythmias #heart #failure #EHJ #cardiotwitter @ESC_Journals @escardio

[European Society of Cardiology Journals @ESC_Journals]

Emery-Dreifuss Muscular Dystrophy 1 is associated with high risk of malignant #ventricular #arrhythmias and end-stage heart failure 👉 https://t.co/qOk5PPqOce

#ESCCongress #EHJ @ehj_ed @rladeiraslopes

[EHJ Editor-in-Chief @ehj_ed]

Emery-Dreifuss Muscular Dystrophy 1 is associated with high risk of malignant ventricular arrhythmias and end-stage heart failure. A simultaneous publication of ESC congress presentations.

https://t.co/BRxJjGnZbY
@escardio @ESC_Journals #CardioTwitter #heartfailure #arrhythmias

[Douglas Cannie @dougcannie]

@rbarvil Thank you, @rbarvil! Great to see you at the @ESCCongress2023.

[Douglas Cannie @dougcannie]

With thanks to our amazing collaborators from across Europe and the USA. @ProtonotariosA @ath_bakalakos @xenux88 @vnparikh @euanashley @rbarvil @FranBermudz @dr_pavia @KSavvatis

[Douglas Cannie @dougcannie]

Very pleased to share our work on carriers of pathogenic EMD variants courtesy of EHJ. Male carriers have a risk of malignant ventricular arrhythmia similar to that of male LMNA variant carriers. @ESC_Journals @UCL_ICS @TheBHF

https://t.co/OVN28gm2Dw

[Usman Tahir @UTahirMD]

Not all Dilated Cardiomyopathy is the same. ⬇️Building on #genetics data of more malignant phenotypes with RBM20 variants, at times with EF > 35%. We need to move towards identifying and managing individuals by their true pathology, rather than generic NICMP/DCM labels

[Alex Protonotarios @ProtonotariosA]

I am pleased to share our editorial and review on the utility of FDG-PET imaging in patients with #ARVC that I and @eleanorwicks have co-authored!

Myocardial inflammation is an emerging phenotypic feature with much to teach us!

https://t.co/Ig2U5Cx3U5

[Douglas Cannie @dougcannie]

@ProtonotariosA Thank you for all of your hard work, @ProtonotariosA!

[Douglas Cannie @dougcannie]

@ProtonotariosA @ath_bakalakos @AnneDybro @fdefrutossemi @Bjerregaard91 @xenux88 @dr_pavia @rbarvil @LorenzoMonserra @fatkinlab @UCL_ICS

[Douglas Cannie @dougcannie]

Delighted to see our work on RBM20 variants now out @Circ_Gen. Both male & female RBM20 variant-carriers are at high-risk of malignant ventricular arrhythmia with male sex strongly associated with end-stage heart failure. With thanks to @TheBHF and our amazing collaborators.

[Circulation: Genomic and Precision Medicine @Circ_Gen]

From Perry Elliot + team: Risks of Ventricular Arrhythmia and Heart Failure in Carriers of RBM20 Variants

https://t.co/zd0fVMzU5c

@AHAScience #AHAjournals #CardioTwitter #Genetics @xenux88 @dougcannie

📽️ @VibhuParcha

[HeartMuscleTalks @heartmuscletalk]

Do not miss the next Heart Muscle Talks session!

Drs @matteodalferro and Alessia Paldino will be presenting on "The importance of the genotype on top of phenotype in managing dilated cardiomyopathies".

🗓Friday, 28/10/2022
🕟15:00 (BST)
Register👉 https://t.co/uKydI4f0pD

[Douglas Cannie @dougcannie]

@ProtonotariosA I’m not ready to talk about it

[Alex Protonotarios @ProtonotariosA]

Very excited to see our paper on "Importance of genotype for risk stratification in #ARVC cardiomyopathy using the 2019 ARVC risk calculator" published at EHJ!

@ESC_Journals @ehj_ed

https://t.co/6zMw7D8IJM

[Douglas Cannie @dougcannie]

@UCL_IHI @alvinaglai @UCL_Wellbeing @PhDVoice @TheUnionUCL @ucl @Nanaki_M22 Cross?

[Douglas Cannie @dougcannie]

@UCL_IHI @alvinaglai @UCL_Wellbeing @PhDVoice @ucl Begonias?