Hariprasad Gupta

[z @rbrzoe]

i'm fucking crying oh my god Gasly was celebrating his podium all the way to the finish line, not knowing he was getting a 10s penalty because Alpine didn't tell him 😭😭😭😭

[Aditya Raj Kaul @AdityaRajKaul]

Extremely Rare Red Sprites Spotted Flashing Over Tibet. They are caused by high levels of electrical activity and form in the upper atmosphere during powerful thunderstorms.

[Dr. AK 🇮🇳 @docakx]

The MiniDock MTB is a new portable rapid TB test (Pluslife, 2025) using tongue swab or sputum.

It detects bacterial DNA in <30 min, costs $3–4 per test ($300 device), and meets WHO accuracy targets—far easier than traditional phlegm microscopy.

A NEJM study of ~1,400 patients across 7 countries confirmed its effectiveness for quicker diagnosis in low-resource settings. WHO recommended it in March 2026.

Drawbacks: May miss early/low-bacterial-load cases; does not detect drug-resistant TB (needs extra tests).

[Goshawk Trades @GoshawkTrades]

Jane Street just showed the inside of their AI training data center in Texas.

4,032 GPUs. 56 racks. 8,000 km of fiber. liquid cooling running through every server because air cooling can't handle the heat anymore.

but the part that got me was the origin story.

Ron Minsky, who co-heads their technology group. said their first compute cluster was literally six Dell boxes stacked on top of each other at the end of a desk row. they called it "the hive."

the trading systems sat out in the room with the traders because they wanted to be able to unplug them if something went wrong.

at one point, someone vacuuming the office unplugged a live trading system in the middle of the day.

from six Dell boxes and a vacuum cleaner incident to a liquid-cooled GPU data center processing trades in under 100 nanoseconds.

that's a 20-year arc.

[Dr Sudhir Kumar MD DM @hyderabaddoctor]

Don’t wait for disease. Know your numbers.
Most heart attacks, strokes & diabetes are predictable years in advance, if you track the right markers.

For Indian adults, these cut-offs matter more than ever:

1. Blood Pressure (BP)
Target: <130/80 mmHg

Even “borderline” BP in Indians carries higher cardiovascular risk due to earlier vascular aging.

2. Fasting Blood Sugar (FBS) <100 mg/dL

Indians develop insulin resistance earlier, even at “normal” BMI.

3. HbA1c <5.7%

Prediabetes starts silently. By the time glucose rises, damage has already begun.

4. Insulin Resistance (HOMA-IR)
Ideal: <2

Insulin resistance (IR) is not routinely measured, but it is extremely useful in high-risk individuals. IR is a hidden driver of diabetes, fatty liver & PCOS.

5. Waist Circumference (Most important for Indians)

Men: <90 cm
Women: <80 cm

🔸“Thin outside, fat inside” (TOFI) phenotype is common.
🔸Waist circumference is better than BMI for risk prediction.

6. LDL Cholesterol
Target
<100 mg/dL (general)
<70 mg/dL (high-risk)

🔸Lower is better; there is no “safe high LDL.”

7. HDL Cholesterol>50 mg/dL

Low HDL is extremely common in Indians and amplifies risk.

8. Triglycerides (TG)<150 mg/dL
High TG is an insulin resistance marker, not just a lipid issue.

9. TG : HDL Ratio<2

🔸TG:HDL ratio is one of the simplest markers of metabolic health.
🔸A ratio of 2 or more is insulin resistance until proven otherwise.

10. hs-CRP (inflammation marker)<2 mg/L

Atherosclerosis is an inflammatory disease, not just high cholesterol.

11. ApoB (the underrated one)

Target: <80 mg/dL (general)
<65 mg/dL (high-risk)

ApoB is better than LDL at predicting risk, as it counts actual atherogenic particles.

12. Sleep Duration
Optimum: 7–9 hours/night

Less sleep is associated with ↑ insulin resistance, ↑ BP, ↑ appetite, ↑ CV risk.

▶️What makes this crucial for Indians?
🔸Higher risk at younger age
🔸More visceral fat at lower BMI
🔸Greater tendency for diabetes & heart disease
🔸Normal-looking person does not mean low risk

▶️If you are above these thresholds, do not panic. Start with exercise, healthy diet, optimum sleep, and consistency. Consult your physician for individual opinion.

Dr Sudhir Kumar @hyderabaddoctor

(Disclaimer: This is not a medical consultation. The information provided here is general in nature, and applies to healthy people, who are not on medications. In any case, consult your doctor for individual opinion)

[Shanaka Anslem Perera ⚡ @shanaka86]

Everyone is covering Terafab as a chip factory.

It is not a chip factory.

Last night in Austin, Elon unveiled a facility that makes masks, fabricates chips, and tests them inside a single building with a nine-month recursive improvement cadence. No such loop exists anywhere else on Earth. Then he told you 80% of the output goes to space. Then he showed you a 100-kilowatt AI satellite with solar panels and radiators, scaling to megawatt range. Then he said Optimus plus photovoltaics will be the first von Neumann probe, a machine capable of replicating itself from raw materials found in space.

Nobody connected the sequence.

Terafab produces 1 terawatt per year of compute. The entire United States consumes 0.5 terawatts of electricity. Musk is building a single factory whose output in AI silicon exceeds twice the power consumption of the country it sits in. And he is sending 80% of it off-planet because Earth literally cannot power what he is building.

Follow the mechanism. Terafab seeds the chips. Starship launches Optimus robots and solar arrays at 100 million tons per year. The robots mine lunar and asteroid regolith for silicon, iron, and nickel. They 3D-print more robots. They fabricate more solar panels. They assemble more AI satellites. Each satellite runs hotter-burning D3 chips designed specifically for vacuum, where free radiative cooling eliminates the thermal constraints that strangle every terrestrial data center on the planet. The nodes replicate. The replication is exponential.

This is a Dyson Swarm bootstrap hidden inside a semiconductor announcement.

The math is public. The Sun outputs 3.828 times 10 to the 26th watts. A 2022 paper in Physica Scripta calculated that 5.5 billion satellites at 290 kilograms each, robotically manufactured from Mars resources, capture enough solar energy to meet all of Earth’s power needs within 50 years. A 2025 paper in Solar Energy Materials calculated a partial swarm capturing 4% of solar output yields 15.6 yottawatts, roughly a billion times current human civilization’s total energy budget. Musk just announced the factory that builds the chips that go inside the satellites that replicate themselves forever.

92% of advanced logic chips are fabricated in Taiwan. One factory in Austin does not fix that. But one self-replicating system seeded by that factory, launched by the only company with reusable heavy-lift rockets, assembled by the only humanoid robot in mass production, and powered by the only star within reach, does not fix a supply chain. It obsoletes the concept of supply chains entirely.

The market priced this as a $20 billion capex story about semiconductor independence.

The actual announcement was the engineering blueprint for Kardashev Type II.

Humanity sits at 0.73 on the Kardashev scale. 18 terawatts. The distance between here and harnessing a star is not a technology gap. It is a recursion gap. And recursion is exactly what a single building in Austin that makes its own masks, builds its own chips, tests its own chips, and launches the output into orbit on its own rockets was designed to close.

Every civilization that makes it past this point never looks back.

[nervemed @nervemed]

Neurotransmitters & Associated Disorders

🔹Schizophrenia - ↑ Dopamine, ↓ Glutamate

🔹Alzheimer’s Disease - ↓ Acetylcholine, ↓ Glutamate

🔹Depression - ↓ Serotonin, ↓ Norepinephrine, ↓ Dopamine

🔹Parkinson’s Disease - ↓ Dopamine, ↑ Acetylcholine

🔹Huntington’s Disease - ↓ GABA, ↓ Acetylcholine, ↑ Dopamine

🔹Anxiety Disorders - ↓ GABA, ↑ Norepinephrine

🔹Mania - ↑ Serotonin, ↑ Norepinephrine, ↑ Dopamine

🔹ADHD - ↓ Dopamine, ↓ Norepinephrine

🔹Addiction - ↑ Dopamine

🔹OCD - ↓ Serotonin

🔹Tourette Syndrome - ↑ Dopamine

🔹Epilepsy - ↓ GABA, ↑ Glutamate

🔹Myasthenia Gravis - ↓ Acetylcholine (receptors)

🔹Botulism - ↓ Acetylcholine release

🔹Tetanus - ↓ GABA, ↓ Glycine

🔹Migraine - ↓ Serotonin

🔹Chronic Pain / Hyperalgesia - ↑ Substance P

[Narendra Modi @narendramodi]

Today, India takes a defining step in its civil nuclear journey, advancing the second stage of its nuclear programme.

The indigenously designed and built Prototype Fast Breeder Reactor at Kalpakkam has attained criticality.

This advanced reactor, capable of producing more fuel than it consumes, reflects the depth of our scientific capability and the strength of our engineering enterprise. It is a decisive step towards harnessing our vast thorium reserves in the third stage of the programme.

A proud moment for India. Congratulations to our scientists and engineers.

[William A. Wallace, Ph.D. @WilliamWallace]

Iron supplements are typically dosed daily, sometimes split into two doses. Both strategies fight the body's own regulatory system.

When you take 60 mg or more of elemental iron, the liver releases hepcidin, a hormone that binds ferroportin, the only iron export channel on intestinal cells, and degrades it. With ferroportin gone, the next dose sits in the enterocyte and never reaches the bloodstream. This shutdown lasts about 24 hours. By 48 hours, hepcidin clears and ferroportin is restored.

Stoffel et al. (2017) tested this in 40 iron-depleted (but not anemic) women given 60 mg ferrous sulfate on consecutive vs alternate days. The alternate-day group absorbed 21.8% per dose versus 16.3% for consecutive dosing. Total iron absorbed was also higher: 175 mg vs 131 mg.

A 2019 follow-up tested women with iron-deficiency anemia, a population where hepcidin is already partially suppressed by the body's demand for red blood cells. Even there, fractional absorption was 40-50% higher on alternate days. That's the stronger finding: the hepcidin rebound still limits absorption even when the body is actively trying to override it.

Caveat: all studies used ferrous sulfate in women. Whether the effect holds for other iron forms or in men is untested.

Moretti et al., Blood, 2015.
Stoffel et al., Lancet Haematology, 2017.
Stoffel et al., Blood, 2019.

[Formula 1 @F1]

A first podium in red for Lewis Hamilton!! 👏❤️

#F1 #ChineseGP

[Nirmal Pandey MD DM Neurologist @nirmalregency]

#MRI for #neurologist is a "Acronym Jungle." 🌿

The same scan has ⓷ different names depending on the vendors:

Siemens, GE, Philips.

Let’s decode the "Big 3" and help you traverse it from a #Neurology POV.

🧵| 8

[Formula 1 @F1]

Introducing the 2026 F1 opening titles! 😍

#F1 #AusGP

[Dr Prashant Mishra @drprashantmish6]

Container cost

[Sukhada @appadappajappa]

Be very scared…

[Hariprasad Gupta @dr_hpg]

@Reddy1798 @DexterousRd You will receive an email from company they will send once a year.

[Dr Kamlesh Darji @DrKamleshDarji1]

The pain of osteosarcoma is cruel. Tumor bone spikes tear nerves and capillaries, while prostaglandins and cytokines flood the area, overstimulating nociceptors so intensely that the brain forgets what normal ever felt like. So be kind to cancer patients. #Cancer #Oncology

[Sergio Pérez @SChecoPerez]

Perhaps 🤣

[Formula 1 @F1]

LANDO NORRIS IS THE 2025 FORMULA 1 WORLD CHAMPION!!!! 🏆

#F1 #AbuDhabiGP

[ari @itsnotme_ari]

“I’m happy with my decision to be at Williams. I remember when I arrived here last year dressed in all white without any sponsor on my suit and a white helmet and the people felt sorry for me”

“Meanwhile I was thinking this team is gonna be good for my future. One year later there is 3 podiums and a good year to start my year at Williams”

Carlos 😭🤍

[PTC Industries @Ptcil]

𝗔 𝗗𝗲𝗳𝗶𝗻𝗶𝗻𝗴 𝗟𝗲𝗮𝗽 𝗶𝗻 𝗜𝗻𝗱𝗶𝗮’𝘀 𝗔𝗲𝗿𝗼-𝗘𝗻𝗴𝗶𝗻𝗲 𝗝𝗼𝘂𝗿𝗻𝗲𝘆 🚀

In a defining moment for India’s aerospace journey, PTC Industries has received a Purchase Order from 𝗚𝗧𝗥𝗘, 𝗗𝗥𝗗𝗢 for Post-Cast Operations of 𝗦𝗶𝗻𝗴𝗹𝗲 𝗖𝗿𝘆𝘀𝘁𝗮𝗹 ‘𝗥𝗲𝗮𝗱𝘆-𝘁𝗼-𝗙𝗶𝘁’ 𝗧𝘂𝗿𝗯𝗶𝗻𝗲 𝗕𝗹𝗮𝗱𝗲𝘀 — marking 𝘵𝘩𝘦 𝘧𝘪𝘳𝘴𝘵 𝘵𝘪𝘮𝘦 𝘢𝘯𝘺 𝘐𝘯𝘥𝘪𝘢𝘯 𝘤𝘰𝘮𝘱𝘢𝘯𝘺 has been entrusted with this advanced manufacturing.

Unveiled at the 𝗟𝗼𝗸𝗮𝗿𝗽𝗮𝗻 𝗖𝗲𝗿𝗲𝗺𝗼𝗻𝘆 of our Titanium & Superalloys Materials Plant at SMTC, Lucknow, in the august presence of the 𝗛𝗼𝗻𝗼𝘂𝗿𝗮𝗯𝗹𝗲 𝗥𝗮𝗸𝘀𝗵𝗮 𝗠𝗮𝗻𝘁𝗿𝗶 𝗦𝗵𝗿𝗶 𝗥𝗮𝗷𝗻𝗮𝘁𝗵 𝗦𝗶𝗻𝗴𝗵 𝗝𝗶 and 𝗛𝗼𝗻𝗼𝘂𝗿𝗮𝗯𝗹𝗲 𝗖𝗵𝗶𝗲𝗳 𝗠𝗶𝗻𝗶𝘀𝘁𝗲𝗿 𝗦𝗵𝗿𝗶 𝗬𝗼𝗴𝗶 𝗔𝗱𝗶𝘁𝘆𝗮𝗻𝗮𝘁𝗵 𝗝𝗶, this milestone places India among a select few nations mastering 𝘵𝘩𝘪𝘴 𝘮𝘰𝘴𝘵 𝘤𝘰𝘮𝘱𝘭𝘦𝘹 𝘴𝘵𝘢𝘨𝘦 𝘰𝘧 𝘫𝘦𝘵-𝘦𝘯𝘨𝘪𝘯𝘦 𝘮𝘢𝘯𝘶𝘧𝘢𝘤𝘵𝘶𝘳𝘪𝘯𝘨.

These Single Crystal components 𝗳𝗼𝗿𝗺 𝘁𝗵𝗲 𝗵𝗲𝗮𝗿𝘁 𝗼𝗳 𝗻𝗲𝘅𝘁-𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝗼𝗻 𝗮𝗲𝗿𝗼-𝗲𝗻𝗴𝗶𝗻𝗲𝘀 — demanding precision across machining, grinding, brazing, vacuum heat treatment, and thermal-barrier coatings. The collaboration between GTRE and PTC strengthens India’s march towards 𝗔𝗮𝘁𝗺𝗮𝗻𝗶𝗿𝗯𝗵𝗮𝗿 𝗕𝗵𝗮𝗿𝗮𝘁 in advanced propulsion and materials technology.

The execution will draw upon PTC’s state-of-the-art infrastructure in India and the integrated capabilities of 𝗧𝗿𝗮𝗰 𝗣𝗿𝗲𝗰𝗶𝘀𝗶𝗼𝗻 𝗦𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝘀, 𝗨𝗞, ensuring seamless delivery of these world-class components.

This achievement marks India’s ascent among the world’s leading aero-engine nations — a bold step from dependence to 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝘀𝗼𝘃𝗲𝗿𝗲𝗶𝗴𝗻𝘁𝘆, and a proud reflection of Indian industry’s growing capability to design, develop, and deliver for the world. 🇮🇳

Read the full update here: https://t.co/sORNczqYd1