Final version is out: aging as the result of loss of goal-directedness
https://t.co/Vmm2zFQHzu
@BeneHartl@LPiolopez
"Although substantial advancements are made in manipulating lifespan in model organisms, the fundamental mechanisms driving aging remain elusive. No comprehensive computational platform is capable of making predictions on aging in multicellular systems. Focus is placed on the processes that build and maintain complex target morphologies, and develop an insilico model of multiscale homeostatic morphogenesis using Neural Cellular Automata (NCAs) trained by neuroevolution. In the context of this model: 1) Aging emerges after developmental goals are completed, even without noise or programmed degeneration; 2) Cellular misdifferentiation, reduced competency, communication failures, and genetic damage all accelerate aging but are not its primary cause; 3) Aging correlates with increased active information storage and transfer entropy, while spatial entropy distinguishes two dynamics, structural loss and morphological noise accumulation; 4) Despite organ loss, spatial information persists in tissue, implementing a memory of lost structures, which can be reactivated for organ restoration through targeted regenerative information; and 5) rejuvenation is found to be most efficient when regenerative information includes differential patterns of affected cells and their neighboring tissue, highlighting strategies for rejuvenation. This model suggests a novel perspective on aging caused by loss of goal-directedness, with potentially significant implications for longevity research and regenerative medicine."
> be me, Intel
> world domination status: achieved
> have a license to print money with x86
> life is good
> be 2007, some fruit company named Apple shows up
> "hey can you make a chip for our new phone?"
> my CFO brain activates
> look at their offer... pathetic
> my margins! my beautiful margins!
> "lmao no," I tell them, "get that low volume, low margin peasant shit out of my office"
> tell them to go bother some Korean foundry
> they call it the "iPhone"
> it only sells, like, a bazillion units
> oops.mp4
> should have listened to my gut, but my gut was too busy counting shareholder dividends
> speaking of shareholders
> CEO is now a finance bro
> innovation is for nerds, stock buybacks are for chads
> spend $36 billion to make line go up
> R&D? how about R&Buyback
> TSMC and Samsung are building fabs? cute.
> we're building value for our shareholders
> meanwhile, in the basement...
> be AMD, literally on life support
> selling their HQ to pay the rent
> "hey guys what if we made a good CPU for once?"
> entire Intel leadership room dies of laughter
> we're still milking 14nm++++ for the fifth year in a row
> what are they gonna do, beat us with... checks notes... core count and efficiency?
> HQ focused on PPT presentations and buybacks
> R&D team: "hey we have this 10nm design but it's kinda... impossible to manufacture?"
> me: "JUST MAKE IT WORK, I HAVE A DIVIDEND TO ANNOUNCE"
> requirement: quadruple the transistor density, tooling: from the stone age, yield: literally negative
> "10nm is fine, everything is fine" for five years
> entire company is stuck on 14nm++++++++
> watching AMD just call TSMC and get a shiny new 7nm node like it's nothing
> suddenly, AMD's "Zen" thing is actually good
> gamers and redditors are calling me a "dead company walking"
> my stock is in freefall
> panic.jpg
> hire back Based Pat Gelsinger to save us
> Pat comes in: "what in the goddamn..."
> find out we're now outsourcing our own chips to TSMC
> mfw we missed mobile, lost the process lead, got rekt by AMD, and our grand plan is to ask the government for money
> mfw we're now a fabless fab with an identity crisis
> mfw the once-proud "Intel Inside" is now "TSMC Inside"
> at least the shareholders had some good quarters
> company_cope.jpg
İstanbul’a 120 km otobüs öncelikli yol planlıyoruz! Amaç, lastik tekerlekli toplu ulaşımda bekleme ve seyahat süresini azaltıp yolculuk kalitesini artırmak.
80 km'lik güzergah belirlendi ve proje çalışmalarına başlandı. İlk pilot uygulamayı 2025’te hayata geçirmeyi hedefliyoruz.
You need to be side quest maxxing. Get your pilots license. Get scuba certified. Go sky diving. Get your coastal cruising certificate. Become a sommelier. Get every niche / pointless certificate & license you can.
Ben bu Halo'nun dizinini kötü sanıyordum, halbuki baya iyi diziymiş ya. Uzayda geçen star wars ve expanse haricinde dizi yok, iptal olmasaymış çok sağlam adaymış.
Olaydan sonra darp raporu alıp şikayetçi oldum. Uzlaşma tekliflerini reddedip dava açtım ve darp kısmı sonuçlandı. Saldırganlar 7500'er lira gibi komik bir cezaya çarptırılmış ve bu cezalar da ertelenmiş. Tehditle ilgili davamız ise hala sürüyor.