Dr Jon Krell

[Dr Jon Krell @drjonkrell]

Currently only people living in the West London Area attending their GP practice. If successful we want a national study https://t.co/Jt6l8ljzhW

[Ovarian Cancer Action @OvarianCancerUK]

Can anybody get involved in this? #OCABRCA @drjonkrell https://t.co/yXhZphuWVR

[Dr Jon Krell @drjonkrell]

Not certain. only 2% of OvCa are due to lynch syndrome. Survival in known
lynch may be better because it is often diagnosed earlier stage https://t.co/cW5LTrcJKz

[Ovarian Cancer Action @OvarianCancerUK]

Fb Q: Is there any difference in survival for patients with Lynch Syndrome as there is for BRCA? @drjonkrell #OCABRCA

[Dr Jon Krell @drjonkrell]

This algorithm is experimental but we hope to validate it in the study and also assess the view of the public of population risk screening https://t.co/7TlbhfbXFW

[Ovarian Cancer Action @OvarianCancerUK]

Can you tell us about the PROGRESS research? #OCABRCA @drjonkrell https://t.co/dFwguG2270

[Dr Jon Krell @drjonkrell]

We developed an algorithm to help determine persons risk of OvCa & Breast Ca by analysing genetic differences in saliva & knowing family Hx. https://t.co/7TlbhfbXFW

[Ovarian Cancer Action @OvarianCancerUK]

Can you tell us about the PROGRESS research? #OCABRCA @drjonkrell https://t.co/dFwguG2270

[Dr Jon Krell @drjonkrell]

PROGRESS is a pilot study aiming to assess to role of 'population testing' for genetic risk of OvCa and other cancers. https://t.co/7TlbhfbXFW

[Ovarian Cancer Action @OvarianCancerUK]

Can you tell us about the PROGRESS research? #OCABRCA @drjonkrell https://t.co/dFwguG2270

[Dr Jon Krell @drjonkrell]

We hope in the future to have screening test to detect ovarian cancer early & to use them in BRCA+ people and other at high risk of OvCa https://t.co/2rtVn4tqw3

[Ovarian Cancer Action @OvarianCancerUK]

Are you seeing earlier diagnosis due to more people knowing their risk thru BRCA testing?
#OCABRCA @drjonkrell

[Dr Jon Krell @drjonkrell]

Also we are working to develop blood tests to detect cancer earlier in low and high risk people https://t.co/2rtVn4tqw3

[Ovarian Cancer Action @OvarianCancerUK]

Are you seeing earlier diagnosis due to more people knowing their risk thru BRCA testing?
#OCABRCA @drjonkrell

[Dr Jon Krell @drjonkrell]

Primary prevention measures such are prophylactic surgery to remove ovaries and fallopian tubes at the appropriate age will help reduce risk https://t.co/2rtVn4tqw3

[Ovarian Cancer Action @OvarianCancerUK]

Are you seeing earlier diagnosis due to more people knowing their risk thru BRCA testing?
#OCABRCA @drjonkrell

[Dr Jon Krell @drjonkrell]

not clear but not yet- still no good early screening test for OvCa. OCA funded research at Imperial e.g. PROGRESS, is looking at this https://t.co/2rtVn4tqw3

[Ovarian Cancer Action @OvarianCancerUK]

Are you seeing earlier diagnosis due to more people knowing their risk thru BRCA testing?
#OCABRCA @drjonkrell

[Dr Jon Krell @drjonkrell]

recent results from trials show that some patients with BRCA+ OvCa can benefit for many years from PARP inhibitors. Unfortunately not all https://t.co/khcnyWBx2a

[Ovarian Cancer Action @OvarianCancerUK]

@drjonkrell https://t.co/WMF72EIBf0

[Dr Jon Krell @drjonkrell]

If BRCA+ & eligible for olaparib then this would be best option. Immunotherapy still experimental and available in certain clinical trials https://t.co/khcnyWBx2a

[Ovarian Cancer Action @OvarianCancerUK]

@drjonkrell https://t.co/WMF72EIBf0

[Dr Jon Krell @drjonkrell]

If further relapse after 6 months from last platinum & carboplatin still effective then olaparib would be available as maintenance on NHS https://t.co/gEbGGaV1gl

[Ovarian Cancer Action @OvarianCancerUK]

@drjonkrell https://t.co/1EOhslBnnX

[Dr Jon Krell @drjonkrell]

But PARP inhibitors are used as maintenance treatment after carboplatin in BRCA+ OvCa in certain circumstances. Discuss with your oncologist https://t.co/i9D6o6xCHq

[Ovarian Cancer Action @OvarianCancerUK]

#OCABRCA https://t.co/RGbXrbOtOp

[Dr Jon Krell @drjonkrell]

carboplatin is often very effective in ovarian cancer and in BRCA+. Keep going with carboplatin if effective. T-cell still experimental https://t.co/aXrEMJ5BjO

[Ovarian Cancer Action @OvarianCancerUK]

@drjonkrell
#OCABRCA https://t.co/ZG2RLG7Ubk

[Dr Jon Krell @drjonkrell]

Not abnormal. OCA & our team are working to spread the message to GPs and the public about BRCA to help prevent cancer and diagnose earlier https://t.co/AE44RBR8AU

[Gilana 🇬🇧🇮🇱 @Gilana25]

@OvarianCancerUK @drjonkrell Surprised- my GP not aware Askenazi women more likely to be at risk

[Dr Jon Krell @drjonkrell]

Probably because when BRCA is abnormal in cancer cells, chemotherapy & PARP inhibitors are more effective. Other reasons not yet known https://t.co/gGlety0cni

[Ovarian Cancer Action @OvarianCancerUK]

FB Q: Do you know why BRCA+ patients (usually a -ive thing) survive longer? Seems odd! @drjonkrell #OCABRCA

[Dr Jon Krell @drjonkrell]

there will however be many drugs or drug trials that I am sure your oncologist can suggest for you. https://t.co/7ptRbuwWa3

[Ovarian Cancer Action @OvarianCancerUK]

Sorry to hear that @anitaalmond
@drjonkrell any suggestions? #OCABRCA https://t.co/Egih4IxxtH

[Dr Jon Krell @drjonkrell]

Sometimes BRCA+ cancer cells become resistant to PARP inhibitors. We don't yet know if giving a different PARP inh in this situation helps https://t.co/7ptRbuwWa3

[Ovarian Cancer Action @OvarianCancerUK]

Sorry to hear that @anitaalmond
@drjonkrell any suggestions? #OCABRCA https://t.co/Egih4IxxtH

[Dr Jon Krell @drjonkrell]

Available via the CDF in patients just diagnosed with OvCa who are having their first chemotherapy but depends on the stage of the OvCA. https://t.co/Jb831UcAu3

[Ovarian Cancer Action @OvarianCancerUK]

Anon: Can you get avastin on the NHS now or is it no longer available? #OCABRCA @drjonkrell

[Dr Jon Krell @drjonkrell]

With the newer drugs on the horizon this may change. A recent study shows for patients surviving for many years, this effect may be lost https://t.co/V4tJzGMSI9

[Ovarian Cancer Action @OvarianCancerUK]

FB Q: Are BRCA+ women with all types of OvCa better off in terms of long term survival or only some types of OvCa? #OCABRCA @drjonkrell