Koon Lee

Haematologist and IEC/CAR T-cell physician

[Gloria Iacoboni @gloria_iacoboni]

Recent Bendamustine Treatment Before Apheresis Has a Negative Impact on Outcomes in Patients With Large B-Cell Lymphoma Receiving Chimeric Antigen Receptor T-Cell Therapy @ASCO

Just published! Here a 🧵explaining the journey behind this manuscript #CART

https://t.co/N1mSu70pnP

[Chimeric Antigen Receptor T-Cell (CAR-T) & Gene Rx @CARTTherapy]

Liso-cel as second-line therapy in adults with RR LBCL who were not intended for HSCT (PILOT): an open-label, phase 2 study https://t.co/r7M7XXP69H
#CART #bmtsm #CARTcell #immunotherapy #tcellrx #ICAN #CRS #CARTcells #CellTherapy #Gene #Genetherapy
@ASTCT @MediHumdani

[Blood Journals Portfolio @BloodPortfolio]

Blood Work: CAR T cells mimicking an aggressive #lymphoma https://t.co/eW4CzDNKhv @cityofhope

[Koon Lee @DrKoonLee]

Dr Kenneth Micklethwaite giving an update on the clinical trials outcome for homegrown CAR T cells at @WestmeadInst @CPMCCWestmead @WestSydHealth #cmpcc . Great work!

[Koon Lee @DrKoonLee]

Entertaining rapid fire talk from Dr Kavitha Gowrishankar re CAR T cell research at @WestmeadInst #cmpcc

[The Westmead Institute for Medical Research @WestmeadInst]

Read a @nature article featuring comments from The Westmead Institute's Dr David Bishop and Professor David Gottlieb on the benefits and challenges of using CAR-T therapy to target lymphoma. https://t.co/tREV5UYPv3

[Koon Lee @DrKoonLee]

Great summary re new analytical models available to explore immune reconstitution with T cell therapy. @EmilyBlyth5 of @WestmeadInst @USyd_Westmead has a knack for simplifying complex concepts. #ISCTANZ2018

[Koon Lee @DrKoonLee]

Excellent talk by Dr Kenneth Micklethwaite at #ISCTANZ2018 about the ongoing CAR T cell trial at @CPMCCWestmead @WestmeadInst Westmead Hospital.

[Koon Lee @DrKoonLee]

Exciting new small molecule STING inhibitors may open up a new front in cancer immunotherapy. Elegant piece of research just published in @nature.

[Nature Portfolio @NaturePortfolio]

A potential new class of immunotherapy drugs to treat some of the most common cancers is reported in Nature. The study shows how these molecules work and what they might mean for the future of cancer treatment. https://t.co/pBk7YvNdU9

[David Gottlieb @djgottlieb]

@LeightonClancy presenting at BLOOD2018. Great results on generating CAR T and pathogen specific T cells.

[Koon Lee @DrKoonLee]

@larsmkn @PeiNi_Ding Axl is a promising target for MDS and BGB324 is in phase I/II. https://t.co/DrCHa24taj
It is nice to see more details of the biology being elucidated by @Medyoufh et al.

[Koon Lee @DrKoonLee]

@BiotechRadar @PeiNi_Ding CAR T cells phenotype results from interplay between various different factors. My suspicion is the distance between CAR and antigen changes binding affinity and lead to downstream divergent phenotypes.

[Koon Lee @DrKoonLee]

Exciting news although bear in mind the trial was without rituximab maintenance. #ESMO2018

[The Lancet Oncology @TheLancetOncol]

Presenting now at #ESMO2018 @myESMO: Frontline VR-CAP vs R-CHOP in transplantation-ineligible patients with newly diagnosed #mantle-cell #lymphoma https://t.co/KXynjjbACx

[Koon Lee @DrKoonLee]

Great talk by Prof Michel Sadelain re improving persistence of CAR T cells #ESMO2018

[Koon Lee @DrKoonLee]

Excellent talk by @subklewe arguing the case for CART cells for relapsed refractory NHL in place of transplant #ESMO18

[Koon Lee @DrKoonLee]

Lively debate about car t cells vs transplant at #ESMO18

[Natacha Bolaños @BolanosNat]

Today we start at #ESMO18 discussing about #CARTcells therapy. Will it replace allogenic transplantation in #lymphoma? This controversy session will give us relevant knowledge to inform #patients appropriately. #Science @knowyournodes @myESMO @EHA_Hematology @sehh_es

[Koon Lee @DrKoonLee]

Triumph of immunology and great public health policy

[The Lancet @TheLancet]

Could #Australia become the first country to eliminate #cervicalcancer within the next 20 years if high-coverage #HPV vaccination and screening is maintained? New modelling study @TheLancetPH #IPVC2018 https://t.co/uNpzYLxkJQ