Mahesh Goel

Professor and chief of Hepatobiliary surgery

[Hepatobiliarysurg_TMH @Hepbilisurg_TMH]

@Kaival_Gundavda @TARPSWG @DrGuruduttVarty @DrKatyayaniC @anantmdesai @anandoncologist @SBonvalot @alegronchi @JasonSicklick @ItaSarcomaGroup @FioreDoc @Sarcoma_UK @chandrajitraut @MufaddalKazi @docswapnil01 @OncoShravan @DrVAChaudhari @aamirparray18
https://t.co/RSPYTJzshp

[Hepatobiliarysurg_TMH @Hepbilisurg_TMH]

🚨Results of our large single center cohort of recurrent RPS!!!
👍Primary surgery = best chance of cure (Median OS- 137 m)
👍Meaningful survival even in recurrent disease
👍Well selected patients… OS > 57m even up to 4th recurrence
@drmgoel @Shraddha_234
https://t.co/RSPYTJzshp

[Hepatobiliarysurg_TMH @Hepbilisurg_TMH]

Predictive nomogram for gallbladder cancers...

Check the link below 👇
https://t.co/hnSMgNYdQk

@drmgoel @Shraddha_234 @drtmshah @MufaddalKazi @DrGuruduttVarty @VikasO @AnantRamaswamy @bhargava611

[IHPBA @IHPBA]

On #IWD2026, IHPBA celebrates the achievements and leadership of #WomenInHPBSurgery. Today we proudly highlight Shraddha Patkar.

🌍✨ Celebrating International Women’s Day 2026 🌍✨

@Shraddha_234 @APHPBA #IWD2026 #GiveToGain

[Hepatobiliarysurg_TMH @Hepbilisurg_TMH]

IVC sarcomas... Involving Bilateral renal ostia!!!
Do we really need to reconstruct???

Resection without reconstruction... our standard procedure
Left renal vein drainage🤔 Collaterals almost always reliable👍

More than 50 cases.. Excellent outcomes!!
3 cases over last 2 weeks!

[Hepatobiliarysurg_TMH @Hepbilisurg_TMH]

@drmgoel @Shraddha_234 @IHPBA @IhpbaIndia @APHPBA @EAHPBA @JSHBPS @IswantoSucandy @ItaruEndo @TorzilliGuido @timpawlik @EAVegaMD @HPBCambridge @KalayarasanRaja @SanjayGovil8 @TARPSWG @SBonvalot @alegronchi @anantmdesai @ItaSarcomaGroup @TataMemorial

[Hepatobiliarysurg_TMH @Hepbilisurg_TMH]

An incredible masterclass by the Stalwarts...
Flawless live demonstration of the intricate nuances of
Robotic right hepatectomy by Prof. Choi
A truly enriching learning feast..
#Oncosurg25!
@drmgoel @Shraddha_234 @DrGuruduttVarty @DrVAChaudhari @pankajch37

[Hepatobiliarysurg_TMH @Hepbilisurg_TMH]

Followed by a mentoring session next day!!!
Prof Choi patiently proctored everyone
Teaching tips and tricks of robotic hepatectomy
@drmgoel @Shraddha_234 @DrVAChaudhari @DrGuruduttVarty

[Hepatobiliarysurg_TMH @Hepbilisurg_TMH]

Gallbladder cancer registry…

The 1st from India…🇮🇳 and largest in the world!!!
1950 patients over 3 years!!!

Insights into epidemiology and roadmap for enhancing care….

@drmgoel @Shraddha_234 @cspramesh

Check the link below👇
https://t.co/dv5f1Dajco

[Gurudutt P. Varty @DrGuruduttVarty]

India must lead the way in GB cancer research. Congratulations to the team on the successful completion of this trial and win! @TataMemorial @ACTREC_TMC

[Hepatobiliarysurg_TMH @Hepbilisurg_TMH]

🥇The best of #APHPBA25
The POLCAGB RCT results presented by @drmgoel
The first ever phase III randomized evidence on neoadjuvant therapy in locally advanced GBC
@Shraddha_234 @ReenaEngineer @VikasO @TataMemorial @IHPBA @IhpbaIndia

[Mahesh Goel @drmgoel]

💡 Conclusion:
First perioperative trial for GBC!
➡️NAT= SOC for high-risk LAGBC
➡️ May extend to borderline/unresectable cases
🚀 Immunotherapy could reshape future GBC management
@TataMemorial @Hepbilisurg_TMH @DrVAChaudhari @Shrikhande_SV @ItaruEndo @timpawlik @skmaithel @DrGuruduttVarty @EAVegaMD @Kaival_Gundavda @cspramesh @AdiKunte @OncoShravan @Saneya_2810 @Sudeeprshah @gvraoaig @KalayarasanRaja @drsadiqs @sonalasthana @PaleswanL @IswantoSucandy @SanjayGovil8 @dramitchopde @KrishMenon16 @DrPankajGarg @IHPBA @IhpbaIndia @HPBCambridge @DrPJagannath @SyedAAhmad5 @VikasO @ReenaEngineer

[Mahesh Goel @drmgoel]

🏆 Big win at #APHPBA2025!
The POLCAGB Trial clinches Best Paper Award at the Plenary Session!
💡 Concurrent chemoradiation + chemotherapy shows improved survival & resection outcomes in locally advanced gallbladder cancer.
@shraddha_234 @APHPBA

[Mahesh Goel @drmgoel]

🔑 Key takeaways from the POLCAGB Trial:
Preoperative chemoradiation in locally advanced GBC (cT3/4, N+) leads to:
✅ Better downstaging
✅ Higher R0 resection rates
✅ Improved OS & DFS
⚠️ Surgical morbidity remains a key concern post-NACTRT

[Gurudutt P. Varty @DrGuruduttVarty]

In summary:
11% of resections were futile

High CA19–9, BR-GBC, and extended resections predict futility

Nomogram helps preoperatively identify patients unlikely to benefit

“Primum non nocere” — first, do no harm

[Gurudutt P. Varty @DrGuruduttVarty]

⚠️ How common is Futile Surgery?
👉 133 of 1196 patients (11.1%)
Median OS:
FS = 8.9 months
Non-FS = 88.7 months
(p < 0.001)

Even among recurrences, OS was worse after FS (6.1 vs 8.9 months).

Slide summary👇🏽
@APHPBA @AHPBA @EAHPBA

[Gurudutt P. Varty @DrGuruduttVarty]

💡 Why this matters:
GBC is an aggressive disease.
Despite “curative” resection, many patients recur or die within months — questioning the value of surgery.
We defined “Futile Surgery (FS)” as recurrence or death within 6 months after resection.
@EAVegaMD @timpawlik @ItaruEndo

[Gurudutt P. Varty @DrGuruduttVarty]

🚨New from TMH!

Can we predict futile Surgery in resectable gallbladder cancers?

Our findings published in @ejsotweets

Link👇🏽
https://t.co/6GTc7L2nUY

Resectable ≠ Beneficial
@Shraddha_234 @drmgoel @Hepbilisurg_TMH

Thread👇🏽
@Shrikhande_SV @cspramesh @TataMemorial

[BJS Open @BjsOpen]

Predicting clinical benefit response after neoadjuvant chemotherapy in locally advanced gallbladder cancer: retrospective analysis
➡️https://t.co/LE3hxMHrOC

A clinically beneficial response (CBR) to neoadjuvant chemotherapy is associated with significantly improved survival. Factors associated with a worse CBR rate include age at diagnosis ≥ 55.5 years, Eastern Cooperative Oncology Group performance status ≥ 1, a platelet count ≥ 468 × 109/l, tumour size ≥ 2.1 cm, T stage ≥ T3 and a systemic immune-inflammation index ≥ 1265.90. Patients with a score of > 25.2 on the nomogram developed to predict a CBR in this study are less likely to achieve a CBR.

👏👏👏@Shraddha_234, Kaival Gundavda , Kaushik Polusany , Raghav Yelamanchi , Gurudutt P Varty , Niket Shah , Akash Pawar , Vikas Ostwal , Anant Ramaswamy , Prabhat Bhargava , Mahesh Goel

#SoMe4Surgery #MedTwitter #SurgEd #Surgery @BJSAcademy @BJSurgery @young_bjs @juliomayol @JJEarnshaw @OUPMedicine #cholangiocarcinoma #gallbladder #some4hpb #some4tpl @hpb_so

[Mahesh Goel @drmgoel]

@HPBCambridge @EAHPBA @AHPBA @APHPBA @IHPBA Congratulations 👍😊