💧 Nuevo análisis conjunto de ADVOR + CLOROTIC + PUSH-AHF: 1.059 pacientes con IC aguda.
🚀 La descongestión intensificada consigue:
↑ natriuresis, diuresis y pérdida de peso
↓ estancia hospitalaria
‼️ Mortalidad hospitalaria 4% vs 7% (OR 0,55), aunque exploratoria
Spironolactone Outcomes RCTs in the Last 20y
#TOPCAT (HFpEF) ❓❌
#SPIRITHF (HFpEF) ❓❌
#CLEAR (Post-MI) ❌
#BARACKD (CKD) ❌
#ALCHEMIST (ESKD) ❌
#ACHIEVE (ESKD) ❌
One day we will hopefully have a positive RCT
to elevate eminence based medicine to evidence based medicine!
Conducting a RCT is challenging. Conducting an independent RCT is very challenging. Conducting a RCT that influences evidence and practice is highly rewarding. Congratulations to the investigators of the #CLOROTIC and #ADVOR trials
#ESCCongress
Excited to share our latest work, now published in @PCVDJournal 🫀
We compared transcatheter vs surgical pulmonary valve replacement in native RVOT, with propensity score matching and 3-year follow-up.
TPVR showed comparable clinical outcomes, with fewer major in-hospital complications, shorter hospital stays, and lower transvalvular gradients.
These findings support TPVR as an effective, less invasive alternative in anatomically suitable patients.
Many thanks to @BorjaRiversa for leading this work and for giving me the opportunity to be part of it, and congratulations to the whole team!
Por fin un ensayo clínico de outcomes CV con Metformina❗️
Como era de esperar:
Metformina no reduce muerte ni hospitalización por IC en ICFEr
en pacientes con DM2 o prediabetes.
Que necesaria es la investigación y no basar nuestra práctica clínica en dogmas sin evidencia científica
📌 Este estudio de nombre impronunciable (TRIC-I-HF-DZHK24) es muy rompedor 🚨 #ESCCongress 🇩🇪
🎯 La terapia borde-a-borde tricúspide ⬇️ ☠️ e ingresos 🏥 por ICC en pacientes con IT severa sintom��tica
🆕 Una ⬇️ de un 60% de eventos 🫀. NNT de 4 para ☠️ -ingreso 🏥 Wow 🥶
Importancia de solicitar Nt ProBNP y Ca125 en pacientes con ICA para estratificación del riesgo; Importante estudio del Hospital Ramon y Cajal;
@paullaceriborra@DRPPison
Gracias por seguir aportando evidencias en IC 🩺📍📚❤️
🔬 ¿La FEVI sigue siendo la mejor herramienta para estratificar riesgo en pacientes muy ancianos con ICA?
✍️ n=830
👥87 años
💧Perfiles de congestión definidos por BNP y CA125
✅ Mostraron mayor capacidad pronóstica
https://t.co/X5dNBZOw67
@paullaceriborra
📢Very important and timely subanalysis of CLOROTIC. The addition of Hydrochlorothiazide to loop diuretics increased📈diuretic response irrespective of baseline Cl in AHF. @ICardiacaSEC@CardioRenalSEC@IcyfaSemi
Delighted to share the publication of the #EDICA study in @JCardFail
https://t.co/vjovzicGGw
In patients 🏥 with acute HF, a natriuresis/diuresis-guided decongestion strategy (@escardio guidelines) vs a weight-guided one showed:
✅ Greater 5-day NT-proBNP reduction
🟰 5-day clinical decongestion
🟰 Length of stay & 30-day outcomes (🏥/☠️)
🟰 Safety & feasibility
🔎 Trend toward not sustained ⬆️ 24–48 h diuresis, weight loss, & loop-diuretic dose
Some conclussions:
1️⃣ Time matters: earlier identification of diuretic resistance improves biomarker decongestion
2️⃣ Yet this did not translate into better short-term clinical outcomes
🎯Still need to close the gap between decongestion and clinical outcomes:
Timing of assessment? Faster titration? Earlier combination diuretic therapy?
Thanks to the great collab of Cardiology - Internal Medicine - Emergency Dep
@MartaCoboMarcos@JanBiegus@esthermonteroh@fernidom@DeCastro9@dr_pavia@segoviajavierve@ICardiacaSEC@secardiologia@CardioRenalSEC@HospiPtaHierro@Sociedad_SEMI@IcyfaSemi@SEMES_
@MartaCoboMarcos presentando los highlights del congreso #HeartFailure2026 en HFpEF y HFmrEF. Y el EDICA trial seleccionado en la sesión de highlights en Acute HF.
Cerramos un congreso excelente con gran representación nacional.
Orgullosos del Dream Team Cardiorenal 🇪🇸❤️💪🏼
🫁 Derrame pleural en ICA
❗️Existe impacto Px?
🆕➡️ El Dr Pisón esclarece nuestras dudas
✅ Prognostic Impact of Pleural Effusion in Acute Heart Failure and Its Link to Diuretic Therapy
@paullaceriborra@DRPPison@LuisMan40850574#HeartFailure2026
🔝Iniciamos la jornada con una mesa sobre Síndrome Cardiorenal
👉 De la mano de Dr Pau Llàcer
▶️ SGLT2i, finerenone, and beyond: orchestrating the cardiorenal
#HeartFailure26