Job Herrmann

MD | PhD-candidate Cardiology | Heart Failure and Fluid restriction | FRESH-UP study | Radboudumc | Netherlands

[Job Herrmann @CardioJob]

#ACC25 #FRESH-UP study investigated liberal fluid intake compared to fluid restriction in chronic HF.

💧 KCCQ-OSS was not significantly different (🚰 vs 🚱; +2.17 95%CI −0.06 to 4.39; P=0.06)
💧Thirst distress higher in restricted patients
💧 No harm signals for liberal intake

[Job Herrmann @CardioJob]

🔥The Effect of a Change in Fluid Intake Advice on Outcomes in Chronic Heart Failure: FRESH-UP subanalysis

💧Patient on pre-trial fluid restriction randomised to liberal intake: increase KCCQ-OSS and decrease in thirst distress.
💧And vice versa

https://t.co/4R5N1a8Pir

[Heart_BMJ @Heart_BMJ]

Fluid restriction in patients with heart failure: a systematic review https://t.co/4UpOCfvyWZ

[Ash Paul @pash22]

Fluid restriction in patients with heart failure: a systematic review https://t.co/n84KKFgvOj via @CardioJob et al

[American College of Cardiology @ACCinTouch]

ICYMI: Don’t miss the Top 🔟 News Articles of 2025, featuring major trial results, global #CVD insights, and practice-changing updates: https://t.co/N70WjN5xrX

🔥 #JACC Global Burden of CVD
🔥 DAPA-HF and DELIVER
🔥 FLUNITY-HD
🔥 RIVAWAR
🔥 FRESH-UP
➕ More!

#CardioX

[EHJ Editor-in-Chief @ehj_ed]

The year in cardiovascular medicine 2025: the top 10 papers in heart failure: read more in EHJ.

https://t.co/B3bAMI4sqc

#HeartFailure #EHJ #Cardiology @ESC_Journale @ESCardio

[Johann Bauersachs @JBauersachsMD]

🔥 Hot of the press in EHJ 🔥
Top 10 papers in heart failure 2025

@ShelleyZieroth @DavidDuncker @ehj_ed @EJHFEiC @HFA_President @Herzmedizin_de

The year in cardiovascular medicine 2025: the top 10 papers in heart failure https://t.co/YfIiIy87J4

[American College of Cardiology @ACCinTouch]

Don’t miss the Top 🔟 News Articles of 2025, featuring major trial results, global #CVD insights, and practice-changing updates: https://t.co/N70WjN5xrX

🔥 #JACC Global Burden of CVD
🔥 DAPA-HF and DELIVER
🔥 FLUNITY-HD
🔥 RIVAWAR
🔥 FRESH-UP
➕ More!

#CardioX

[Yonah @tehrani_md]

💧 FRESH-UP trial update: No big benefit from fluid restriction in chronic HF (NYHA II-III).
Liberal fluid intake ≈ restricted (<1500 mL) for quality of life — but less thirst distress with liberal fluids!

#HeartFailure #HF #QualityOfLife #Cardiology #ACC25 #MedTwitter

[Dorian L. Beasley MD, FACC @cardiojaydoc02]

The attending cardiologist on service confirming there are no routine fluid restrictions for heart failure patients. #FRESHUP #acc25 https://t.co/bZ2goem1ON

[markusathome @MarkusAtHome]

Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial (FRESH-UP) by Drs. @CardioJob, Roland R.J. van Kimmenade et al didn't result in a significant difference in health status.

https://t.co/e4jl3pHppa

[Dhruva Biswas, MD/PhD @dhruva_biswas]

#ACC25 Sim-pub 🚨📢
FRESH-UP RCT 🥤
504 outpatients w HF
Liberal fluid intake vs fluid restriction ≤1.5L/d
At 3-months, no difference in health status (KCCQ-OSS) or safety events (mortality/hospitalization/IV LD use), but 📈 thirst distress in fluid restriction arm
Led by @CardioJob @CardioRoland
https://t.co/bub3i3PqAG
@NatureMedicine @ACCinTouch

[Frank Gommans @gommans_fr63227]

Any questions on the FRESHUP study? Now your opportunity to ask them!
Meet-up zone 1
@ACCinTouch #ACC25

[RTL Nieuws @RTLnieuws]

Minder drinken bij hartfalen? Nergens voor nodig, zeggen onderzoekers https://t.co/yqNod3uyu5

[American College of Cardiology @ACCinTouch]

Limiting fluid intake may have no benefit for patients with #HeartFailure, according to findings from the FRESH-UP study presented during a Late-Breaking Clinical Trial session at #ACC25.

Check out the key findings ➡️ https://t.co/hVqEY34Uie

[American College of Cardiology @ACCinTouch]

#ACC25

[Alison L. Bailey, MD @a_l_bailey]

One of the most important trials at @ACCinTouch #ACC25 ! Compared fluid restriction to liberal approach in #HeartFailure. Why?

This affects individuals w/HF EVERY DAY!
✨No benefit of Fluid Restriction
✨No HARM for liberal fluid intake
✨Improved QOL in liberal fluid intake

[Job Herrmann @CardioJob]

Published in @Naturemedicine

https://t.co/oKUHtmalqA

[Job Herrmann @CardioJob]

#ACC25 #FRESH-UP study investigated liberal fluid intake compared to fluid restriction in chronic HF.

💧 KCCQ-OSS was not significantly different (🚰 vs 🚱; +2.17 95%CI −0.06 to 4.39; P=0.06)
💧Thirst distress higher in restricted patients
💧 No harm signals for liberal intake

[Job Herrmann @CardioJob]

The FRESH-UP study enrolment is complete!

Soon we will know the effect of liberal fluid intake vs fluid restriction on the quality of life of chronic heart failure patients.

@CardioRoland @GommansFrank @DrJaarsma @NielsRoyen @LisetteBaltusse @JCardFail

https://t.co/JgASllclIh

[Robert Mentz, MD @robmentz]

@CardioRoland @WilfriedMullens @kevin_damman @_antocannata @MajaCikes @JustinEzekowitz @PieterMartensMD @AlexMebazaa @jozinetm @FH_Verbrugge @GMCRosano @HFA_President @HanCardiomd @doctorchecho Looking forward to the FRESH-UP Study Results:
https://t.co/3YOZd4Y79R
@dranulala @HFSA @JCardFail @DukeHFDoc