⚡ What does complement activation actually DO?
🔥 C3a/C5a → inflammation + chemotaxis 🎯 C3b → opsonization + more convertase 💥 C5b-9 → membrane attack complex → cell activation/lysis
A small trigger can become a BIG inflammatory response.
❓Why complement, and why now?
🛡️ It protects us from infection. 🔥 But excessive or poorly regulated activation can injure glomerular endothelium, mesangium, podocytes & tubules.
💊 Unlike steroids, complement drugs target this cascade directly.
This was the first I came across BAC or breast arterial calcification being used as a marker of vascular calcification
This small crossover study, surprisingly showed that the BAC progression was actually higher with citrate dialysate as compared to non- citrate based dialysate, contrary to what we would expect !!
Hello, Nephrofam!
#TheWeeklyNephron is back !
ICIs have rewritten cancer care, but the kidney pays a quiet price.
Immune-related AKI is under-recognised, and often asymptomatic.
A practical guide for the onco-nephrology interface 👇
🧵 by @DrAkshayaJ
MERCURI-2 says dapagliflozin cuts AKI after cardiac surgery by nearly half. Promising, right?
Break down how AKI was defined, and the "kidney protection" is mostly just... more urine and dapa is a mild osmotic diuretic🌊
#nephjc video made by @DivyaveerSSNeph@ayushiexplores
@thisis_drgsp@the_hindu@nephromythri@drgirishns I am reminded of our Poster on “Approach To The Diagnosis And Management Of ADPKD: An Indian, Bangladesh & Srilankan Perspective - A Survey Study” was presented by @swaminathaniisc at the #ISNWCN in Japan. Ultrasound was the initial modality used for diagnosis of PKD in most pts.
#TheWeeklyNephron is back, this time with a made in 🇮🇳 recipe!
✨Research is only as valuable as the lives it improves. Yet, despite major advances in nephrology, too little reaches our kidney pts.
This one, however can be applied to your patient today.
🧵by @DrAkshayaJ
Kidney Konversations Podcast Episode 19A - Peritoneal Dialysis (in #Tamil) - Education for the general public.
With @DrAkshayaJ & Dr Sampath Kumar.
On @Spotify👉 https://t.co/eope2mogkI
On @ApplePodcasts 👉 https://t.co/uUbKxdKFtw
🚨A New #NephJC short 🩳
The first trial in pregnancy and CKD in 30 years - ORCHARD BEET 🌳
Aiming to test feasibility of nitrate administration in pregnant women with CKD by @CristinaDeReins#NephTwitter
https://t.co/YSxmliSsmc
Kidney Konversations Podcast | Episode 19
Peritoneal Dialysis in India: beyond the prescription. With Drk Sampath Kumar, Dr Sandeep Mahajan @DrAkshayaJ and @taruna_pahuja
On Spotify 👉 https://t.co/QmMstlMjzA
On Apple Podcasts 👉 https://t.co/32LBIuwMDV
https://t.co/xqGdza4BGh
#DYI How long a patient can survive on Peritoneal dialysis?
Is Hemodialysis superior to Peritoneal dialysis
Let's hear and learn about all the Truth and MYTHS About #peritonealdialysis in this @kidneykonversations PODCAST
@kidney_warriors@Vasuragh
🎙️ Kidney Konversations | Episode 19
Peritoneal Dialysis in India: beyond the prescription. With Dr Sampath Kumar & Dr Sandeep Mahajan
🎧 Worth a listen: Will change your perspective towards PD!
🔗: https://t.co/ukVjMMuZAp
👩🏻💻: https://t.co/NF9nLlaPrz
🎙️@taruna_pahuja@DrAkshayaJ
The Weekly Nephron is back!
And the Onconeph fever is not over yet.
📝We have yet another paper (an accepted manuscript rather) @CKJsocial guiding us on a practical and confusing question!
This week’s 🧵 is by @DrAkshayaJ@ERAkidney@PepaSolerR@ClaraGCarro@simeoni_m
You have my attention...
Four (4...) doses of dapagliflozin (pre-op and post-op) in elective cardiac surgery reduced AKI vs placebo, 28% vs 52%!!!
SGLT2 Inhibitors for Prevention of AKI https://t.co/UP5ShrwnRA