Troy stapleton

Radiologist (Medical specialist) living with Type 1 diabetes, whole real food/Paleo/Low carb, high protein healthy fat lifestyle. Novice surfer, cyclist, sailor

[Amy Tenderich @AmyDBMine]

Well heck… i’ve wasted a few good Dexcom sensors this way. Great to see #CGM going in the right direction in terms of less interference/ fuss/ waste 👍🏼 https://t.co/KHJ7qSlo4Q

[Harrison Schenck @FractionalList]

Making family dinners non-negotiable has one of the highest ROIs of anything you'll do as a dad

[Brent Toderian @BrentToderian]

In the last 20 years, 44 hectares of Paris car parking has been transformed, making room for wider sidewalks, bikes and buses (15ha), bike racks, EV spots, accessible space, & 2.2K new patios/terraces for outdoor dining. 90% of trips in the city are via walking, biking & transit.

[Andrew Koutnik, Ph.D. @AKoutnik]

New “CURE” for Diabetes?

A NEWS article in NATURE (https://t.co/erk1uz5eju) claims  woman reverses here diabetes with stem cell. The patient reported that she “can eat sugar now,” and “…enjoy eating everything — especially hotpots.” 

Is this a “CURE” for T1D?

Should we expect all patients with T1D to be insulin free in the near future?”

NO…atleast not yet. We must be cautious with the term “CURE” and this is NOT THE FIRST STUDY to demonstrate a perceived “CURE” for T1D. In the year 2000, a research group demonstrated for the first time they could IMPLANT INSULIN PRODUCING BETA CELL and restore normoglycemia (https://t.co/s1nnFX9HgJ)…this work is now cited almost 7000x.

This has a REMARKABLE impact on the field with people slinging for the first time: “CURE” around. Stating it was now just “around the corner”….but here we are 24 years later WITHOUT A CURE… what happened?

1)      Most got back on insulin

2)      Experienced weight gain

3)      All were on immunosuppresants

4)      Islet cell implants deteriorated over time AS THE IMMUNE SYSTEM STILL KILL THESE CELLS OVER TIME.

THE IMMUNE SYSTEM HAS AND REMAINS ONE OF THE LAST BARRIERS

However, this…NEW STUDY in CELL (https://t.co/qDy49FLzw7)… has been shared with people again claiming a “CURE” but this time from STEM CELLS.

So what is NEW here? What should we be excited about? These researcher took a 25 year old patient who had had T1D for a decade.

1)      They extracted her own tissue, specifically her FAT where they could derive STEM CELLS cells. STEM CELLS are a unique cell type which can “differentiate” into other cell types.

2)      Using a NOVEL chemical mix in a petri dish, these researchers were able to transform  these stem cells into CHEMICALLY INDUCE INSULIN PRODUCING BETA CELLS

3)      The patient was IMPLANTED last year in 2023 and 75days later she was INSULIN INDEPEENDENT with NORMOGLYCEMIA as of 1-year post implantation… REMARKABLE!

What is novel about this study if a cure has been observed before and this is actually not the first study to show stem-cell derived insulin producing beta cell in vivo? The novelty was the way they chemically induced the stem cells in COMBINATION with a more favorable implantation site. This is a REMARKABLE ACHIEVEMENT…BUT IT IS NOT A CURE…yet. Just like the last “CURE” over 20 years ago, was not the cure. …but this does demonstrate yet another critical advancement to the slow steps towards getting one…

It must be noted that the immune system remains a critical barrier as chronic immunosuppressant use does have long-term risk and have been demonstrated in some analyses to shorten life expectancy.

[orange? @generic_orange1]

Wellington city is doing something very few cities have ever attempted: Building a complete cycleway network from scratch.

Here are three maps showing the progress..

Map #1: The future

This is how it will look like once all the current bike lane projects are complete.

[@Bicycle_Network @bicycle_network]

It is time for governments to alter their approach, release the handbrake and watch e-bikes take off alongside electric cars.

Placed on equal footing, these two could achieve great things together.

https://t.co/i7oE0Hbgxl

[Timmy Crowe @timmy400h]

If you have a few moments to listen to this interview as a parent with your child.
Possible one of the best post race interviews I have ever watched #PlayOn

[Dr. Buzz Aldrin @TheRealBuzz]

July 20th, 1969 is a date that stands high in my life – it was the day that we, together as one people, achieved the greatest scientific and technological feat in human history. The specific role that Neil, Mike and I performed in the event was but one part of an immeasurably larger effort – not just for our nation, but for all mankind. As I look back on what we accomplished 55 years ago, I am still inspired by what we all saw and did – the best of America and the best of humanity. Thank you for the privilege and the honor of serving you, and for being part of this exciting and wonderous journey with me. #Apollo11

[Troy stapleton @drtroystapleton]

@radRounds @erica_tirr 3

[Prof. Feynman @ProfFeynman]

Be teachable. You're not always right.
Humility is necessary for growth.

[Andy Boenau @Boenau]

It's great timing that e-bike technology is improving at the same time so many communities are ready to reform zoning. E-bikes offer a viable option to driving for people who wouldn't even consider hopping on a normal pedal bike to get around.

[Melissa & Chris Bruntlett @modacitylife]

Ubiquitous across the Netherlands, "fietsstraten" (bicycle streets) retain limited access for cars but treat them as guests.

@Streetfilms spotlights the Belgian adaptation in Ghent; which improves walking and cycling while adding seating and green space.

https://t.co/jDuP1ahfmE

[GlobalCyclingNetwork @gcntweet]

🎉 He did it! All smiles in the @MarkCavendish household tonight! 🤗
#35
#tdf #tdf2024 #tourdefrance

#GCNracing #RoadBike #GCN #Racing #GlobalCyclingNetwork #CyclingLife #Bicycle #RoadCycling #Cyclist #BikeLife #BikeRacing #CycleRacing #Bike #cycling @AstanaQazTeam

[Melissa & Chris Bruntlett @modacitylife]

At peak times, three cyclists enter the bike parking below Utrecht Central Station each second. That’s 180 per minute, 10,800 per hour…

Great train service induces more cycling, and great bike infrastructure induces more train travel. A virtuous circle of sustainable transport.

[Matthew Syed @matthewsyed]

The “conspiracy of silence” in this election campaign is no accident. Voters can’t yet (with apologies to Jack Nicholson) handle the truth.

Open Access @thetimes⁩

https://t.co/Hqbmo4lm8X

[Brent Toderian @BrentToderian]

Some are asking versions of “what’s more free than cars?”

Choices.

Choices are more free than car dependency.

It’s actually not a hard concept.

I’m not pitting cars against any other single mode of transport.

I’m rejecting design that creates dependency on just one mode.

[Andrew Koutnik, Ph.D. @AKoutnik]

"It's still about glucose until proven otherwise?"

"99% of complications were predicated on HbA1c"

David Nathan #ADA2024

[Melissa & Chris Bruntlett @modacitylife]

Ten years ago, the five Flanders provinces began an ambitious dream: a 2,800km network of cycle highways to connect all cities and towns in the region.

With a full subsidy from the Flemish government, municipalities have now built 2,000km—like the 25km “F7” from Ghent to Deinze.

[Jazz Sethi @Jazzsethi95]

Diary entry number 8 is a feeling I’ve been struggling for a while to fully put into words.

I think this is the best way I could!

For me - “home” means safety. And sometimes #T1D just feels “unhomely”

I don’t know if others can relate - but found the words finally!

🤗