David Virant

Molecular biologist, strain engineer and microscopist.

Metabolic Engineering @AciesBio
Personal account.

Opinions are just the cat walking over my keyboard.

[David Virant @DVirilis]

@sflorimm I need it and I'm people

[David Virant @DVirilis]

I'm a consumer and I care about frontier performance!

[gabriel @gabriel1]

consumers pay 20$/month and don't care about frontier performance

enterprise pay $40T/year for intelligence (knowledge work), and really care about frontier performance

focusing on consumer is a mistake and anti-agi pilled

[David Virant @DVirilis]

@LottoLabs GPT5.5 level models on a 3090 next year? :)

[David Virant @DVirilis]

Unpopular opinion, but Google doesn't need the best model, much less the best coding model. Gemini just has to be good enough to power the app ecosystem for the casual user.

[David Virant @DVirilis]

@0xSero I need more 3090s...

[David Virant @DVirilis]

@ATinyGreenCell Less pure than analytical or food-grade

[David Virant @DVirilis]

@AnthropicAI So for a biologist outside the US, absolutely nothing changes?

[David Virant @DVirilis]

My experience on this site lately whenever I see any protein structure at all...

[David Virant @DVirilis]

@Nature

[David Virant @DVirilis]

@0xrinx Explain what a tree is

[David Virant @DVirilis]

@matt503ea5sf9z5 Can't, I work in biology. It's worse than GPT2 for me. And I have a yearly subscription because I believed they would keep releasing useful models. See why I'm a bit miffed?

[David Virant @DVirilis]

@Chaos2Cured Dario is biology-adjacent at best.

[David Virant @DVirilis]

@TensorTwerker I'm terrified of even asking it to audit my bioinfo scripts over fears it'll sabotage them :/

[David Virant @DVirilis]

@europeanhorizon The one decent bank :(

[David Virant @DVirilis]

@PhilShteuck @zandpreme @owl_posting Quantized, of course. And I'm using llama.cpp

[David Virant @DVirilis]

@PhilShteuck @zandpreme @owl_posting Sure, I started with this. The hardware is just the RTX3090 in an older PC rig, 32GB RAM and Ryzen 5 5600X. Nothing special. https://t.co/11aBlLqKoG

[Sudo su @sudoingX]

yep, here's the full stack:

-ngl 99 -c 262144 -np 1 -fa on --cache-type-k q4_0 --cache-type-v q4_0 --port 8080 --host 0.0.0.0

model: unsloth/Qwen3.6-27B-GGUF Q4_K_M, hermes agent as harness pointing at http://localhost:8080/v1, canonical prompt at https://t.co/rajYkRwo2e. tell me how yours lands.

[David Virant @DVirilis]

@owl_posting Ask it to explain the biological function of a leaf on a tree.

[David Virant @DVirilis]

@zandpreme @owl_posting They're out there, but you might have to replace the thermal paste and pads.

[David Virant @DVirilis]

@sri9s The bar is - it actually does what you ask and doesn't flag it as a security risk xD

[David Virant @DVirilis]

@zandpreme @owl_posting Of course I had the rest of the PC, so it wasn't a terribly expensive upgrade, plus is use it for some protein models and of course gaming.
And I wouldn't have bought it, but my wife got it for me for my birthday as a surprise xD