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Translational neuroscience; psychopharmacology; non-motor functions of the cerebellum :
Eukaryotic/eukaryote : orthogonal orientation

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@AetherFox_ @NickTaber I think Popper's student Lakatos has described it best via the operations of a "protective belt of a degenerate research programme".

There's a fun argument that his work on research programmes was informed by his experience of being in Popper's shadow, and a way to subvert him.

[Carlos Mirapeix. @psicopeix]

Mas alla de un rediseño del DSM.
Una perspectiva dialógica que refleje mejor la naturaleza contextual, experiencial y relacional de los trastornos de salud mental, posicionando el diagnóstico como punto de partida para la investigación colaborativa.
https://t.co/EO0YvaozBn

[Nature Human Behaviour @NatureHumBehav]

Thalamic oscillations distinguish natural states of consciousness in humans https://t.co/vH5bG8CjNz

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@markhoro Can't underestimate the effect of self-serving bias, and biases in ego-protective mechanisms for resolving cognitive dissonance... I suspect these operate alongside or on-top of countertransference mechanisms

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@JDaviesPhD This seems contextually relevant:
https://t.co/C70ekJfEiK

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@RCarhartHarris It is! My mind leaps to Friston's recent paper on "active affordance", which I think scales quite cleanly to Nick Land's idea of "hyperstitional capital".

Hypothesis: A nocebo effect in clinical encounters may occur via exhaustion of hyperstitional capital -> behavioural despair

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@YuDai_Tsai Agreed! Anything that helps escape dealing with those "life situations" is associated with long term increases in productivity.

The online social media engagement metrics prove it!

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@RCarhartHarris It is! My mind leaps to Friston's recent paper on "active affordance", which I think scales quite cleanly to Nick Land's idea of "hyperstitional capital".

Hypothesis: A nocebo effect in clinical encounters may occur via exhaustion of hyperstitional capital -> behavioural despair

[Bertoglio lab (FMC/UFSC) @bertogliolab]

Anxiety sensitivity and intolerance of uncertainty track distinct neurobehavioral dimensions of avoidance in anxiety-related disorders
https://t.co/xxyy8LFuuG

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@MithMuel @ruthefordml noted

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@MithMuel @Cooperdavis In philosophy of science this kind of behaviour has been described by Imre Lakatos as "the protective belt of a degenerate research programme".

His work attempted to reconcile Popper and Kuhn, and Lakatos himself classified psychiatry as a pseudoscience, within this framework.

[Bertoglio lab (FMC/UFSC) @bertogliolab]

Psychedelics and neurostimulation for treatment resistant psychiatric disorders
https://t.co/MigEM3Pzas

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Synchronous climbing fiber activity enables instructive signaling for cerebellar learning through modulation of disinhibitory circuits (2026)

https://t.co/Q6JpOAnnc4

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@YuDai_Tsai But does it predict that you will survive further?

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@MithMuel @ruthefordml "It may take some trial and error to find the right combination of drugs for you"

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@markhoro You have my deepest respect for rejecting the easy path of a status-seeking Lakatosian degenerate

[Quantitative Biology (Neurons and Cognition) @BioPapers]

Contextual Role Modulates Object Representational Geometry in the Human Brain

Julien Dirani, Shankar Chawla, Leila Wehbe, Bradford Z. Mahon
https://t.co/7DJotkep4r [𝚚-𝚋𝚒𝚘.𝙽𝙲]

[Bertoglio lab (FMC/UFSC) @bertogliolab]

The development of translational tasks for preclinical psychedelic research in psychiatry
https://t.co/Z5hE5c5QE9

[Cell Stem Cell @CellStemCell]

Online Now! Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems https://t.co/PCq8An23NK #stemcells

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@ompsychiatrist There's also this recent metareview reporting D2 supplementation may increase metabolic clearance of D3.

It may be significant to Indian populations with high rates of plant-based diets. The market looks D3-heavy already, but consider vegans.

https://t.co/JKpQtuQtu1

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@awaisaftab @Cooperdavis Recognition of this Leviathan doesn't necessitate complicity and submission to it. That's a choice, with big 🥕s

Ostracizing non-conforming consumers is cruel.

It is a worthy hill to fight upon. Dumit's paper offers context to your position upon it:

https://t.co/SAeT0N4wHf

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@ompsychiatrist Dumit described the power dynamics between patients and doctors in his paper: Illnesses you have to fight to get: fact as forces... (2006)

It's relevant to the current iatrogenic harm debate, but institutional incentives for exclusion are far greater

https://t.co/n2sK9OkgAf