E. Antonio Chiocca, MD, PhD, FAANS

Chair, MGB Department of Neurosurgery. Harvey W. Cushing Professor of Neurosurgery, HMS. Executive Director, CTNS, MGB Cancer

[MGB Neurosurgery @MGBneurosurgery]

We’re proud to celebrate our faculty recognized on Boston Magazine’s Top Doctors 2026 list. This honor reflects their exceptional skill, commitment to innovation, and unwavering dedication to our patients. Congratulations!

@BostonMagazine @wenyalindabi @EAChiocca @GolbyLab @BrianNahed @draliazizsultan

#BostonDoctors #MGBNeurosurgery #neurosurgery

[MGB Neurosurgery @MGBneurosurgery]

We are excited and honored to announce the inaugural Mass General Brigham (MGB) Neurosurgery Residency Program, integrating the two neurosurgery residency programs at MGH and BWH. Please find more information in the graphic above. #MGB #NeurosurgeryResidency #Residency #MGBNeurosurgery

[MGB CTNS @MGBCTNS]

We are thrilled to share that Patrick Wen, MD has been named the Section Head of Hematology/Oncology for theGlioblastoma & High-grade glioma Program within our Center for Tumors of the Nervous System (CTNS) in the Mass General Brigham Cancer Institute.

#MGB #CTNS #GBM

[MGB CTNS @MGBCTNS]

"Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of NeuroOncology (EANO) Consensus Review on Current Management and Future Directions" by Rahman R, Batchelor TT, Chiocca EA et al., Neuro-Oncology. Read here: https://t.co/dAsFGE27ln

[ACIR @ACIR_org]

Ling et al. provided a longitudinal multiomic view of human glioblastoma (GBM) evolution under intratumoral oncolytic viral therapy (CAN-3110), demonstrating the feasibility and importance of serial tumor [...] https://t.co/szSoQ8Gmxa  @MGBneurosurgery  @EAChiocca

[Mass General Brigham @MassGenBrigham]

The Mass General Brigham Cancer Institute harnesses the expertise of @MassGeneralNews and @BrighamWomens and our entire system—delivering world-class care, groundbreaking research, and a personalized experience for every patient. Learn more: https://t.co/ty32Bc1nFe

[E. Antonio Chiocca, MD, PhD, FAANS @EAChiocca]

An insightful new article explores how oncolytic viruses are reshaping immunotherapy for glioblastoma. “Oncolytic Virus-Mediated Immunomodulation in Glioblastoma: Insights from Clinical Trials and Challenges” Featuring Drs. Raziye Piranlioglu and E. Antonio Chiocca! 🧠🦠

#Neurosurgery #PatientCare #Glioblastoma #MGB

Read here: https://t.co/kTjDr8cBGu

[MGB CTNS @MGBCTNS]

Dr. David Ryan shares updates on the MGB Cancer Institute, outlining the mission and goals for the coming years. A powerful start to the afternoon session at #CTNS2025. #CancerResearch #MGBCTNS

[MGB CTNS @MGBCTNS]

Thank you to all who participated and contributed to making our second Faculty Retreat a success! #MGBCTNS

[Jun Kim @Jun_kiim]

Just published in Nature (June 2025), Andersen et al. (@EAChiocca, Reardon, @QuintanaLabHMS) developed a novel viral barcode interaction-tracing (RABID-seq) platform, uncovering previously unknown immunosuppressive interactions between astrocytes and glioblastoma (GBM) cells.

Through a bidirectional ANXA1–FPR1 signaling axis, ANXA1 expression in astrocytes suppressed NF-κB inflammasome activation, thereby driving immunosuppression, while FPR1 activation in GBM cells inhibited immunogenic necroptosis. Targeting this axis resulted in enhanced infiltration and activation of dendritic cells (DCs), tumor-specific CD8+ T cells, and macrophages, significantly augmenting antitumor immune responses.

The RABID-seq method developed here, if integrated with spatial analyses, can offer unprecedented resolution into the complex cell-cell interactions within the GBM TME. Critically, identification of the astrocyte–GBM ANXA1–FPR1 axis as a key mechanism of immune evasion and tumor progression provides a promising target for therapeutic intervention, either as monotherapy or as part of combination strategies to significantly enhance the efficacy of immunotherapies for GBM.

@MassGenBrigham @harvardmed @broadinstitute @DanaFarber @kochinstitute

[Kee Park @keepark]

Global Neurosurgery in Action: The Boston Declaration 2025 and Its Ripple Effect https://t.co/g7g7nfrFka via @AANSNeurosurg
@grosseaumd @draliazizsultan @EAChiocca @MGBneurosurgery @HarvardPGSSC

[AANS @AANSNeuro]

E. Antonio Chiocca, MD, PhD, FAANS (@EAChiocca), has been named President-elect of the AANS for the 2025–26 term. A pioneer in neuro-oncology and molecular medicine, Dr. Chiocca is Chair of Neurosurgery at @BrighamWomens and Neurosurgeon-in-Chief at @MassGenBrigham. His visionary leadership and groundbreaking research will help shape the future of neurosurgery. #neurosurgery #AANSNews https://t.co/PesSlSuJdE

[giuseppe Minniti @gminniti2012]

Fully and busy day at the Neuro-Oncology masterclass in Padua organized by @DrLombardiGiu . We had a great session on meningiomas and now Just listening an Amazing talk by @EAChiocca on new Therapeutics for GBM
@EORTC
@EANOassociation
@SapienzaRoma

[gelareh-zadeh @gelarehzadeh]

@AANSNeuro @EAChiocca @BrighamWomens @MassGenBrigham Congratulations @EAChiocca
An A++ Grade colleague to have!

[NREF @NREFORG]

In the wake of the heartbreaking loss of Michael W. Groff, MD, FAANS, his wife Dr. Joy Saini, and their children Karenna and Jared, the Groff Family Memorial Fund has been established to honor their remarkable lives. This fund pays tribute to their legacy of excellence, compassion and service by supporting future leaders in neurosurgery.
Learn more: https://t.co/E7gzTk5jC6

[Jun Kim @Jun_kiim]

Harvey Cushing Neuro-Oncology Laboratories (HCNL) 2025 @EAChiocca @MGBneurosurgery @harvardmed

[Neurosurgery Publications @NeurosurgeryCNS]

#NEUNewIssue https://t.co/JzCrKTQyCq #NEUEditorsMessage Why Research? by @EAChiocca
#CNSGuidelines CNS Guideline for Brain Metastases & #NEUReview Decoding Glioblastoma Heterogeneity: Neuroimaging Meets Machine Learning & more! @CNS_Update @DKondziolkaCNS @george_maragkos

[NS Tumor Section @NSTumorSection]

#Gray_in_May
Have you listened to Prof. @EAChiocca 's talk on Oncolytic Immunotherapies in Glioblastoma?
You can check the recording anytime by clicking the link below:
https://t.co/pLQCsp49E2
@hadjiMDPhD @noorulhudamaria @AANSNeuro @MassGeneralNews @brigham

[MGB Neurosurgery @MGBneurosurgery]

Exciting News! "Mass General Brigham Study Finds That Patients with Glioblastoma Who Received Gabapentin Lived Longer", lead author of the publication, MGB Neurosurgery Fellow, Joshua Bernstock, MD, PhD, (@jbernstock1) states, "This study is an exciting step forward." Read all about the findings here: https://t.co/V7DQT3NJOP #Publication #NeurosurgeryNews #Glioblastoma #MGBNeurosurgery