Mark Mochel

Dermatopathologist and Surgical Pathologist

[Mark Mochel @ectomorphologst]

Now online in Modern Pathology.
Melanomas with activating RAF1 fusions.

https://t.co/2MILenYrfa

[Jake Bledsoe @jake_bledsoe]

CYLD-mutated anal squamous cell carcinoma: An uncommon entity associated with cylindroma-like morphology and adverse clinical features - ScienceDirect https://t.co/DrAgUVQzHQ

[Jake Bledsoe @jake_bledsoe]

Have you ever seen an anal carcinoma with cylindroma/adenoid cystic like features? It’s a thing. Don’t confuse it with a cutaneous adnexal tumor or BCC!!

And probably my last ever publication in GI pathology… #pathology #pathtwitter

[Mark Mochel @ectomorphologst]

@IHC_guy @Vik_deshpandeMD @jake_bledsoe Somewhere in Rosai 10th Ed, he mentions that the morphology of these basaloid carcinomas may reflect glandular or adnexal differentiation - I think that’s what the sox10 positivity is also trying to tell us.

[Mark Mochel @ectomorphologst]

@IHC_guy @Vik_deshpandeMD @jake_bledsoe Not too many studies where the mutation presence and immunostain are lined up for comparison. Basal cell adenoma/carcinoma are sox10 positive and have the mutation in some proportion. Similarly with spiradenomas (a minority are driven by cyld).

[Mark Mochel @ectomorphologst]

@Vik_deshpandeMD @IHC_guy @jake_bledsoe The analogous cyld mutant basaloid carcinomas of the head and neck are also Sox10+ (as are cylindromas, which of course share the mutation)

[Sumaiya Iqbal @Sumaiyalqbal]

Have ever wondered it would be useful to have a handy tool for quick mapping and investigation of mutations, together with functional/genomic scores or any protein residue-wise annotation on protein 3D structure? Especially when the mutation is rare and de novo? 1/10

[Christine J. Ko, MD @ChristineJKoMD]

Could be useful for cases of unknown primary: UV Mutational Signatures Among Cutaneous Primary Tumors https://t.co/Lvucj9riUd via @JAMANetworkOpen part of @JAMANetwork #medtwitter #dermtwitter #dermatology #dermpath

[Jeffrey Cloutier, MD, PhD @JCloutierMD]

Excited to share our new paper on nodular fasciitis of the breast, now out in @ModernPathology ➡️ https://t.co/ZxBVaXovGO

Accurate diagnosis on biopsy may prevent potentially unnecessary surgical excision. #breastpath #BSTPath

[Arnaud de la Fouchardiere MD, PhD @melanopath]

In the wake of working with @ProfRScolyerMIA on the chapter of Primary lung melanoma in the latest lung blue book we have just published a new case of this extremely rare entity. @IARCWHO #Melanoma #Pulmpath #PathTwitter
https://t.co/uYPRzkD4E7

[Rondell Graham @rondell_graham]

New study: There is a mathematical relationship that describes where anatomic substructures in the normal liver are located. The liver is logical. Congrats to my excellent colleague @RogerMo74821186

https://t.co/NXBN6Kf6Is

@MayoClinicGIHep @Caldera60373705 @DrHSLovesLiver

[Lisa Rooper @LisaRooperMD]

Sclerosing polycystic adenoma is a salivary tumor with mixed ductal, acinar, and myoepithelial elements that was previously considered non-neoplastic- but recent identification of PTEN/PI3K pathway mutations proved it is a neoplasm (PMID: 31605313). #ENTPath #SurgPath #IHCPath

[Daniel Berney @daniel_berney]

Rather desperate discussion this morning on correct plural of Condyloma accuminatum.... we found our answer!! @smlungpathguy https://t.co/x73JrcvBnT

[Jeffrey Cloutier, MD, PhD @JCloutierMD]

Inflammatory rhabdomyoblastic tumor with progression to high-grade rhabdomyosarcoma and aggressive clinical behavior.

Most cases seem to follow an indolent clinical course, but there appear to be rare exceptions.

➡️ https://t.co/GZqcsHMz6A

#BSTPath @ModernPathology

[AJCP @AJCPjournal]

These authors found INSM1 expression is not exclusive to neuroendocrine carcinomas and should be correlated with other clinicopathologic and immunohistochemical features. https://t.co/RoJPRibUoF

[Arnaud de la Fouchardiere MD, PhD @melanopath]

Immunohistochemistry in melanocytic tumors (introduction) part1/5 (@mela... https://t.co/DwqiX6Mu1Y via @YouTube is now up for viewing
#dermpath #pathology #melanoma

[Melanoma Institute Australia @MelanomaAus]

Most patients with a thin melanoma have excellent prognosis, but not all. Thanks to a new online risk calculator developed by MIA clinicians can now calculate the likelihood a patient’s thin melanoma will spread.
See: https://t.co/V0esnqsmQ6
#riskcalculator #melanoma

[Jake Bledsoe @jake_bledsoe]

Check out our study on clinicopathologic and molecular features of anal squamous cell carcinoma, with emphasis on the significance of HPV & TP53 mutation status and utility of p16 & p53 immunohistochemistry

Online @ModernPathology

https://t.co/nN3TR1hkAR

#pathology #gipath

[Darcy A. Kerr @darcykerrMD]

Older person with a T2 hyperintense, T1 hypointense proximal femur lesion with areas of cortical breakthrough. #BSTPath #GrossPath #OrthoTwitter #MSKRad

[Konstantinos LinosMD @KonstantinosLin]

Our new work is out! A novel fusion in an acral melanoma with potential therapeutic implications. Dartmouth in collaboration with MD Anderson Cancer Center https://t.co/7RgOAJozUi #melanoma #dermpath #cancer #oncology #dermatology

[Andres Martin Acosta (Andy) @Andres_M_Acosta]

Our new article in @ModernPathology . PMPs of the bladder show recurrent FN1-ALK fusions. @cjsalibay @MichelleDunno17 @Williamson_SR @drmehrarohit @JGordetsky @plessthanpt001 @DianitaOramas @DraEosina @rovingatuscap @DrRizwanRasheed @TobiAdelajaMD @MRNucciMD