Ed Dickey

[NCTM @NCTM]

The 2026 Lifetime Achievement Award recipients have been announced!

Congratulations to Laurie Boswell, Diane Briars, and Douglas Clements 🎉

Read more: https://t.co/9CD6RVe5k0

[Scientific American @sciam]

Sharla Boehm, a math teacher, spent her summers coding. She’d go on to build what would eventually evolve into the Internet
https://t.co/CrBCPESeLQ

[Veera Rajagopal  @doctorveera]

A monumental moment in medical history: the first gene therapy for genetic hearing loss is now FDA approved. As a former Regeneron scientist, I feel very proud. I had the opportunity to hear about this programme while it was still in development. It’s one of the few programmes that, every time you came across it, you felt the medical breakthrough in your bones and privileged just to be there while it was happening.

At this moment, it’s important that we look 30 years back when researchers mapped a locus on chromosome 2 to congenital deafness in a Lebanese family (https://t.co/o8ltjHyLNy). They named it DFNB6 (later DFNB9) with no clue about the responsible gene. Three years later, the causal gene came to light: OTOF, encoding a protein called otoferlin (https://t.co/tBGlFPzaQd). Seven years after that, in 2006, pioneering work by Christine Petit revealed that otoferlin is a calcium sensor in the inner hair cell membrane, acting as a molecular trigger that converts sound into electric signals that the brain can read (https://t.co/oxXtifPrTZ). Twenty years fast forward, we now have a successful treatment. Thirty years from discovery to medicine.

OTOF-related deafness is congenital, caused by complete deficiency of otoferlin. In these children, the cochlea is structurally intact, hair cells are there, the mechanics of sound transmission work. It’s just that final step, where hair cells hand off the signal to the auditory nerve through neurotransmitter release, that doesn’t happen. Sound arrives and dies at the synapse. It’s deafness due to a defect in the synapse caused by the absence of a single protein, which is what made this a beautiful, clean target for gene therapy.

The treatment itself is a feat of molecular engineering. OTOF is too large to fit in a single AAV capsid. The team solved this elegantly by delivering the gene in two halves separately, which then get spliced to produce the full functional protein. A single surgical injection into the cochlea, a molecular miracle unfolds. Results from the CHORD trial were striking: of 20 evaluable patients, including children as young as 10 months, 80% showed meaningful hearing improvement, and by 48 weeks, 42% had achieved normal hearing including the ability to hear whispers. Otarmeni is not only the first gene therapy for deafness, it’s also the first dual-AAV therapy to be approved by the FDA.

There are very few things in medicine that come close to giving back a sense like vision, hearing, or touch that a human never had from birth. It’s almost God’s work. A parent witnessing their child who was born deaf hearing their voice for the first time, it’s a joy that no words can describe. Multiply that by the fact that it came from a single injection, a repaired gene, and 30 years of science. We are truly in the golden era of medicine.

Regeneron press release:
https://t.co/6zvdsT2uzI

Below video is from the NEJM publication of CHORD trial (Valayannopoulos et al. NEJM 2025)
https://t.co/YvIqwQ0SDu

[Ed Dickey @EdDickeyUSC]

@MilaLovesJoe @grok are there republican Senators receiving big pharmaceutical contributions?

[Ed Dickey @EdDickeyUSC]

@EricLDaugh Darwin Award coming soon

[NCTM @NCTM]

ICYMI: We are hosting a live webinar where you can chat with the MET Board about available grant opportunities, get insider tips on proposal requirements, and ask questions.

Fall cycle grant applications are due November 1. 💰

Sign up today: https://t.co/kokT757Cox

[NCTM @NCTM]

TONIGHT! 👉 If you are a doctoral candidate or early career mathematics educator with a research idea, don't miss our upcoming webinar on the Early Career Research Grant—you could receive up to $10,000 in funding! 💰

Open to all! Sign up here: https://t.co/ilehGtqfIs

[NCTM @NCTM]

ICYMI: Are you a doctoral candidate or early career mathematics educator with a research idea? Don’t miss our upcoming webinar on the Early Career Research Grant—you could receive up to $10,000 in funding! 💰

Open to all! Sign up here: https://t.co/ilehGtqfIs

[Ed Dickey @EdDickeyUSC]

@StacyAndy9 26 yo $18,000 in 1976 at 8%
Sold in 1979 for $27,000 and bought second for $56,000

[Ed Dickey @EdDickeyUSC]

Great insights on teacher retention.

[SC TEACHER @SCTEACHERtweets]

The new data visualization from #SCTEACHER presents fresh insights into #SouthCarolina teacher mobility, exploring 2023–24 patterns of statewide mobility, net changes in teachers across SC school districts & more.

Download the new release: https://t.co/aMiLu8P7xb

#sc #k12

[NCTM @NCTM]

Do you know someone has made a great impact in #mathematics education? If so, we invite you to nominate them for the NCTM Lifetime Achievement Award. 🏆

Join our interactive webinar to learn more: https://t.co/rcw4qrNb2P

Submit your nomination here: https://t.co/wVOy2IWCb4

[NCTM @NCTM]

This #GivingTuesday, consider a tax-deductible donation to NCTM's Mathematics Education Trust (MET) and give #math educators the support, tools, and resources they need to improve the teaching and learning of #mathematics: https://t.co/eKyW4Gqb2e

[Ed Dickey @EdDickeyUSC]

@CollinRugg If this group of grifters convinces the majority of voters that Trump can lead, then America will get what it deserves. My hope is the electorate is not that stupid.

[Ed Dickey @EdDickeyUSC]

@historyinmemes Up there is the transition in Ashes and Diamonds from flaming bullet holes in a running man’s the back to flaming liquor glasses on a table

[Ed Dickey @EdDickeyUSC]

@thanh_neville Happened in Lyon

[Ed Dickey @EdDickeyUSC]

Great opportunity to secure funding for projects that will impact math learners https://t.co/OF0No3XFvM

[Ed Dickey @EdDickeyUSC]

@techknowmath In a world where + or - cost a penny, mult a nickel, div a quarter, and exponentiation 50 cents, this is quite cheap and “simple”
,

[Ed Dickey @EdDickeyUSC]

@blu3r4d0n As a color blind person, the colors are perfect.

[Ed Dickey @EdDickeyUSC]

@theemmamont Giving NC a 3 month taste of Robinson as Gov should be enough to ensure he loses in November

[Ed Dickey @EdDickeyUSC]

@Mike_Uva Baseball is a great game. The balls did not bounce in our favor around 3rd base but it was a great tournament run.