Adeeb

A Winged Hussar.
Neurosurgeon.
A wanderer for meaning in life.

[Adeeb @edi_opteron]

@atmghn Freshly graduated NS here, and yes, I hardly did or do any bone fragments compaction due to excessive bleeding since we're dealing with a traumatic case by default and the theatre can go bloody rapidly.

[Adeeb @edi_opteron]

@AliBaajMD The entirety of my hospital's OR cannot match the price of the equipment involved in this picture..
Free-Hand-ing everything and anything...

[Adeeb @edi_opteron]

I see purpose in life no more.

[Adeeb @edi_opteron]

@atmghn Watched the whole video enthusiastically. Definitely corrupt stats.

[Adeeb @edi_opteron]

@atmghn we need more of such insightful, forward looking perspectives to recalibrate our envisions and actively search those fields for breakthroughs.

[Adeeb @edi_opteron]

Coming from a religious conservative family but as soon as I hear Eminem's playing in the gym I go straight for the bar without warmup. The pump is crazy.

[Aakash Gupta @aakashgupta]

Heart disease kills more people than every cancer combined. Lilly just published Phase 1b data in the NEJM on a single injection that could prevent most of it. Permanently.

The science starts with a genetic accident. A small percentage of people are born with a broken PCSK9 gene. Their livers clear LDL cholesterol so efficiently that researchers tracking them over 15 years found up to 88% fewer coronary events. The effect was so large it looked like a data error.

The reason is timing. Statins lower your cholesterol at age 45. A broken PCSK9 gene lowers it from birth. Decades of low LDL compound into plaque that never forms in the first place. You can't reverse 40 years of arterial damage with a pill. You can prevent it entirely with a gene.

VERVE-102 is a base editor. Single IV infusion. One letter changed in your liver cells' DNA. The PCSK9 gene turns off permanently. Phase 1b results across 35 patients: 88% reduction in PCSK9 protein, 62% drop in LDL cholesterol at the highest dose. Durable at 18 months. The effect didn't fade.

Lilly paid $1.3 billion to acquire Verve Therapeutics for this program. The global statin market does roughly $16 billion a year selling daily pills that patients take for life. If a single infusion replaces 30 years of daily medication, Lilly didn't buy a drug. They bought the retirement plan for an entire drug class.

One shot to join the genetic lottery that most of the population lost.

[Adeeb @edi_opteron]

Just when I thought physics cannot surprise me no more...

[Ź̵̸̢̛̙͍̖̠̖͛̎̿̋̀ͅÓ̴̰̠̙͇̪͓̩̣̭͕͙̯̮̱̋̓̄̋̏̓̿̔̐̏̎̕͜ͅV̸ @zoverions]

This is one of my absolute favorite concepts in theoretical physics because it sounds like pure mysticism, yet it was proposed by one of the most rigorous minds of the 20th century to solve a very practical problem.

John Wheeler wasn't just trying to be poetic; he was trying to explain why every electron has the exact same charge and mass. In our macroscopic world, no two apples are identical down to the atom. But every electron is perfectly fungible.

Here is how I break down the "One-Electron Universe" through a systems lens.

The Ultimate Data Compression

If you view the universe as an information processing system, the "One-Electron" theory is the ultimate example of the "Don't Repeat Yourself" (DRY) principle in coding.

Instead of the universe needing to instantiate 10^80 separate "electron" objects—each requiring its own memory allocation and tracking—it essentially instantiates one object and loops it through the temporal dimension infinitely.

From this perspective, what we perceive as "billions of electrons" existing at once is actually just a cross-section of a single, incredibly long, knotted thread. It’s like slicing through a ball of yarn; you see hundreds of little circles (electrons) on the cut surface, but it’s really just one strand tangled up in 4D space-time.

The Antimatter Implication

The most brilliant part of Wheeler's idea—and the part that Richard Feynman actually ran with—was the explanation for antimatter.

If an electron is traveling forward in time, we see it as negatively charged matter. But if that single thread loops back and travels backward in time, the physics dictates that its charge would appear reversed relative to our flow of time. We would see a positively charged electron.

We call that a positron.

This models "annihilation" (when matter and antimatter touch) not as destruction, but as a U-turn. The electron isn't destroyed; it just turned a corner in time and went the other way.

The Logical Flaw (and the Philosophical Gold)

There is a major hole in the theory that Wheeler admitted: if there is one electron going back and forth, there should be an equal amount of matter (forward) and antimatter (backward) in the universe. But there isn't; we observe vastly more matter. Wheeler jokingly argued that the "missing" positrons were hidden inside protons, but the math didn't quite hold up.

However, the philosophical implication remains structurally profound. It suggests that identity is an illusion of time.

If you remove the temporal coordinate, the distinction between "this" electron in my brain and "that" electron in a star explicitly vanishes. It challenges the assumption that quantity equals separateness. It hints that at the deepest layer of reality (what I call the Substrate), separation might just be a rendering artifact of the operating system we call "Time."

[Adeeb @edi_opteron]

Amidst the rising tensions between the left and right and grotesque murders and political espionage, I invite my friends to read this amazing piece of recent decades in Italy.
History repeats itself. Everytime.

— Years of Lead

https://t.co/rMz5D8Qjaf

[Adeeb @edi_opteron]

@Dearme2_ a cheap perfume with 48hrs of longevity is definitely a chemical mess filled with fixatives. Stay away from such beast modes regardless of the price.

[Adeeb @edi_opteron]

@AliBaajMD Getting hyped for your next 15yrs innovating in this field. Keep up the good work prof.

[Klaas Meijer @klaasm67]

Stunning! The Dutch Army has named its new tank regiment after Princess Amalia — a tribute to our future queen and a proud symbol of national strength and tradition.

[Adeeb @edi_opteron]

@TheWatchB Arguably the best looking Rolex today.

[Adeeb @edi_opteron]

What could possibly happen to heat up the already torn up Middle East, one might ask?

- Exactly.
A BVR Dogfight.
- Casualties?
France's cutting edge Gen. 4.5 Rafales.

[OSINTdefender @sentdefender]

Pakistan’s Prime Minister claims that five fighter jets operated by the Indian Air Force were downed during last night’s missile attack and resulting escalation, with all of the aircraft claimed to have been shot down by Pakistani J-10Cs using PL-15 Air-to-Air Missiles.

[Adeeb @edi_opteron]

@robgraymd Would you please elaborate? Couldn't really get your point on industry embodies education.

[Adeeb @edi_opteron]

The hospital's gate officer held me today to renew the clearance badge on my car though since there are only 4 days left to finish residency, I wasn't enlisted for a renewal. Thus, I had to peel off the badge..
What a life lesson... from the state of power to no one.

[Adeeb @edi_opteron]

@ratnayakemd No HemoVac drain?

[Adeeb @edi_opteron]

@ShahabSattari @DrJudyHuang @BettegowdaMDPHD @DrNTheodore @HopkinsNsurg Congratulations dear Dr. Sattari, our esteemed former AJUMS colleague and a source of inspiration. You cracked the impossible! Well done mate.

[Adeeb @edi_opteron]

@ChavezRamzes PXA?

[Adeeb @edi_opteron]

I have a thing or two for food vlogs done behind the steering wheel.
The crave I start to develop is insane.