Ed Merricks

🧠 Associate neuroscientist at Columbia University. Recording neurons in patients to try to understand seizures/cognition. Now residing where skies are bluer 🔕

[Brain @Brain1878]

Using single-neuron recordings, Agopyan-Miu et al. show that territories with distinct ictal activity patterns coexist in limbic structures and that, in many cases, the hippocampus may be less involved in driving seizures than clinical recordings suggest. https://t.co/SlVfqFFyPB

[Elliot Smith @50kDinar]

more 🔥🔥🔥 from Alex A-M & @edmerix et al. Single neuron recordings of seizures in deep structures.

Cell-type specific and multiscale dynamics of human focal seizures in limbic structures https://t.co/VRRnQD164E

[Kyle @LillisintheLab]

Going to #AES2022 and interested in what makes the big wiggles in EEG at seizure onset? Come to the IW on "Cellular Contributions to Epileptiform EEG" Sunday, 8:45a, 106B, with talks by @edmerix, @SarahFMuldoon, and Lauren Lau. Ephys, Ca2+ imaging, networks, more! @AmEpilepsySoc

[Elliot Smith @50kDinar]

Hot new paper alert:

Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures
https://t.co/wyreLqrbWy

congrats @edmerix @melanieboly !!!

[Ed Merricks @edmerix]

@buccino_alessio @50kDinar @Tomdonoghue @QasimEtal Oh, completely agreed, it would be great to see that as a common metric. Like I say, used correctly I think it’s fantastic, congrats! Perhaps it’ll help standardize definitions of multi- vs. single-units across papers too...

[Ed Merricks @edmerix]

@50kDinar @Tomdonoghue @QasimEtal p.s. Am I right in thinking you're working with @neurojosh now? Perhaps we should have a larger research-group get together about standardizing the spike sorting here... (clearly I can tweet/bore for hours about it)

[Ed Merricks @edmerix]

@50kDinar @Tomdonoghue @QasimEtal Ultimately, spike sorting has some subjective elements (for now) so to acknowledge that and keep the same method/parameters/subjectivity across all conditions is key, imo.

[Elliot Smith @50kDinar]

#tweeprint alert!!!

Check out our latest #preprint using Utah style microelectrode arrays to understand how interictal epileptiform discharges relate to spontaneous human #seizures:

https://t.co/0o0KDT3MDz

@UofUNeurosurg @UofUCNC @UtahNeurosci

[Ed Merricks @edmerix]

@AylandLetsinger @NeuronlineSfN @SfNJournals All about those #science #aesthetics!

[Ed Merricks @edmerix]

@AylandLetsinger @NeuronlineSfN @SfNJournals @AylandLetsinger Very happy to share the code I used on GitHub. Also, if you're into that sorta stuff, check out this video I made "flying" through the same waveforms! https://t.co/8o6qXajqp6 (It's on my profile too, but Twitter compression is not kind to neurons...)

[SfN Journals @SfNJournals]

New #JNeurosci research from @edmerix et al. shows that transient, predictable changes to action potential waveforms are a defining feature of neurons that have been recruited to a seizure, coexisting with stable waveforms in adjacent, unrecruited cortex.
https://t.co/hacPDt2lmi

[Ed Merricks @edmerix]

So my cover art submission for our recent paper wasn't chosen (very understandable—their choice is beautiful!), so I decided to turn it into a "cover" for the paper! Might have to do this for all publications going forward... #coverneuron #science #coverart

[Ed Merricks @edmerix]

p.s. Twitter video compression gettin' you down? Here's the same video in better quality! https://t.co/8o6qXajqp6

[Ed Merricks @edmerix]

Made a #science vid! Flying through action potentials from a human entorhinal #neuron, showing the loss of spike shape during a seizure... And the full paper exploring this finding (and its deeper meanings) is now available in all its peer-reviewed glory: https://t.co/4oFVz2sE2x

[Ed Merricks @edmerix]

Thanks for the shout-out and for all the help getting it there @50kDinar!

[Elliot Smith @50kDinar]

Another cool paper from @edmerix!

Neuronal firing and waveform alterations through ictal recruitment in humans

https://t.co/BXO3WQZop0