Eli Metzner

PhD candidate @thenormanlab | csBio @mskcancercenter | Computational Biology & Medicine @cbm_student

[Thomas Norman @thenormanlab]

Can we recreate the transcriptional states seen in single-cell atlas projects? In our new preprint we try to do this using large-scale Perturb-seq experiments. Along the way we discuss off-target effects of CRISPR epigenetic editors and identify drivers of key fibroblast states.

[Thomas Norman @thenormanlab]

Excited to share our preprint "Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome & epigenome". This work extends single-cell CRISPR screens to simultaneously profile gene expression & chromatin accessibility.