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Elise White π³οΈβππ³οΈβπ
@elisew00
Biophysics PhD candidate in the Woodson Lab @ Johns Hopkins | NIH F31 Fellow | Learning the Hfq-RNA tango & how tertiary motifs choreograph ribozyme folding.
Baltimore, MD
Joined March 2011
679 Following
572 Followers
869 Posts
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Iβm honored to have been awarded the NIH F31 Ruth L. Kirschstein National Research Service Award (NRSA) fellowship from @NIAIDTraining! So thankful to my awesome mentor @woodson_lab for all her support & guidance. Go RNA (and Hfq)! #WomenInSTEM #Gotthegrant π©βπ¬π§¬
@Society4Science @MayaAjmera Sooo awesome!! ππ Maya, Iβm grateful for all that you and @Society4Science do. Iβm a 2017 ISEF alum - my own research on the Tau protein was inspired by a family member with Alzheimerβs. ISEF solidified my passion for biophysics, and Iβm now a PhD student at Hopkins.
@sciqst @woodson_lab (2/2) In contrast, uridines in the proximal pore may undergo local motions within one binding pocket, but movement to a different pocket is restricted. Together, if an mRNA is also bound to Hfq, these motions may allow the sRNA to rapidly explore base pairing opportunities.
@sciqst @woodson_lab (1/2) Thanks! Thatβs a great question. We donβt know the exact physical origins of these motions yet, but we have some good ideas from structures and models. At the rim, uridines may slide / transfer between arginines while staying globally associated with Hfq.
Who to follow
PauloCTSouza
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Martini developer, Researcher at ENS-CNRS in Lyon, consultant, trying to make CG models more useful for molecular design and drug/vaccine delivery π₯οΈ+πΈ=ππ
Siewert-Jan Marrink
@CG_Martini
Martini lover.
Shaken, stirred or self-assembled.
Ariane Nunes Alves
@anunesalves
Computational Biochemist | Lead Researcher @CNPEM | Associate Editor @jcim_jctc | π§π·
#CompChem (ligand binding kinetics, crowding)
Excited to share our new paper! This was a fun project, and Iβm grateful to all who made it possible! π§¬π
Our new paper is out! Using 19F NMR, we show that Hfq rewires the conformational dynamics of a model sRNA in a site-specific manner. Uridines at the rim undergo faster exchange (~100 ΞΌs) than those in the proximal pore (~300 ΞΌs). Congrats Elise! ππ https://t.co/ndsRJ18Ub1
@may_khanna @woodson_lab Thanks, me too! ππ I hope this strategy can be used to look at how other RNA-binding proteins alter the ΞΌs-ms dynamics of their RNA ligands!
Our recent #singlemolecule study on RNase J decay is out! Congrats, Yuan! ππ
https://t.co/YqayNptMzC
I had a blast with these apple-solutely brilliant scientists on Saturday!
This bunch of RNA lovers knows how to unwind! Enjoying A-U-tumn and apple picking ππ
Iβm so honored and thankful to have won a poster prize @MeetingRna! I learned a lot this week from this lovely community. Thanks to the organizers for putting on another excellent meeting.
Off to Strasbourg for the 2025 Regulating with RNA in Bacteria and Archaea Meeting! βοΈπ«π·
Congrats, Jorjethe and Yi-Lan! ππ
Our new paper is out in PNAS! We show that competition for binding to the Hfq matchmaker disfavors mismatched sRNA-mRNA combinations while allowing matched sRNA-mRNAs to form stable pairs. Kudos to Jorjethe Roca and Yi-Lan Chen for their fantastic work! https://t.co/EqhYB0ZGDs
@charliersmith1 You guys make a beautiful couple! Iβm so sorry youβve had to deal with so much hate (those folks are just unhappy and insecure). What you two have is special, cherish it and donβt stop posting!
Happy #InternationalWomensDay2025! Iβm endlessly grateful for my journey from being an Intel ISEF finalist to a biophysics PhD student @ JHU #StandUpForScience
Standing up for science with JHU Biophysics in DC! #StandUpForScience
@HalvorsenLab @JibinPunnoose @arunrichardc @MoryaVinod @TheRNAInstitute Congrats all! Really cool work!
The Woodson Lab is migrating to Bluesky! Follow us here: https://t.co/PKUHXKkczt
@StevensSostre @HHMINEWS Huge congrats! Youβre such an inspiration!
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