Steve’s Bat

yes, I’m still sweet

[Steve’s Bat @emteekellie]

How do you uninstall anxiety

[WitchDoctorDB @db_witch]

I went one day without taking my anti depressant and it felt like this

[Lee ⋆✴︎˚｡⋆ @rylandgraceful]

pittsburgh dennis vs philly dennis

[Mostafa Faisal @MostafaFaisal14]

Transplanting Hope: Managing Relapsed/refractory AML
https://t.co/k64otoGP4H

[Dr. Chokri Ben Lamine @abouabdrahman0]

🚨 Common Hematology Drugs: “With or Without Food” Guidance 🩸

1️⃣ Chemotherapy Agents

🔹 Venetoclax (BCL-2 inhibitor) ⚡
•Administration: WITH FOOD 🍽️ (high-fat meal preferred).
•Why? Food increases absorption → consistent drug levels and TLS prevention.

🔹 Imatinib (TKI for CML/Ph+ ALL) 💊
•Administration: WITH FOOD 🍽️ and a full glass of water.
•Why? Reduces GI upset (nausea/vomiting).

🔹 Nilotinib (TKI for CML) ⚠️
•Administration: EMPTY STOMACH ❌.
•Why? Food increases drug absorption → risk of QT prolongation.
•Timing: Take 1 hour before or 2 hours after meals.

🔹 Dasatinib (TKI for CML/Ph+ ALL) 💊
•Administration: With or Without Food.
•Notes: Avoid PPIs (e.g., omeprazole) → reduces absorption.

🔹 Hydroxyurea (Cytoreduction for SCD, CML) 💧
•Administration: WITH OR WITHOUT FOOD.
•Tip: Take with food if GI upset occurs. Stay hydrated to prevent nephrotoxicity.

🔹 Methotrexate (MTX) (Folate antagonist) ⚗️
•Administration: WITH FOOD to reduce GI irritation.
•Tip: Avoid alcohol → hepatotoxicity risk ⚠️.

🔹 Bortezomib (Proteasome inhibitor for MM) 💉
•Administration: WITH OR WITHOUT FOOD.
•Notes: If oral, avoid grapefruit/Seville oranges → CYP3A4 interactions.

2️⃣ Anticoagulants

🔹 Warfarin (Vitamin K antagonist) 🩸
•Administration: WITH OR WITHOUT FOOD.
•Precaution: Consistent Vitamin K intake (green leafy vegetables) to stabilize INR.

🔹 Apixaban (DOAC) 💊
•Administration: WITH OR WITHOUT FOOD.
•Tip: Better adherence if taken with meals.

🔹 Rivaroxaban (DOAC) 💧
•Administration: WITH FOOD (for doses ≥15 mg).
•Why? Improves absorption and efficacy.

🔹 Dabigatran (DOAC) ⚠️
•Administration: WITH FOOD recommended to reduce GI side effects.
•Tip: Do not chew/crush capsules → alters drug release.

3️⃣ Supportive Care Drugs

🔹 Iron Supplements (Ferrous sulfate, fumarate) 💊
•Administration: EMPTY STOMACH preferred for better absorption ❌.
•Exceptions: Take with food if GI upset occurs.
•Avoid: Calcium-rich foods, antacids → reduce absorption.

🔹 Folic Acid (Supportive care for MTX or SCD) 💊
•Administration: WITH OR WITHOUT FOOD.

🔹 Allopurinol (TLS prevention, gout prophylaxis) ⚗️
•Administration: WITH FOOD to reduce GI upset.

🔹 Vitamin B12 (Cobalamin) 💉
•Administration: With or Without Food (oral or IM).

4️⃣ Steroids

🔹 Prednisone/Prednisolone 💊
•Administration: WITH FOOD 🍽️.
•Why? Reduces risk of gastric irritation and ulcers.

🔹 Dexamethasone 💊
•Administration: WITH FOOD.
•Tip: Morning dosing preferred to minimize insomnia.

5️⃣ Antibiotics/Antifungals in Hematology

🔹 Levofloxacin 💊
•Administration: WITH OR WITHOUT FOOD.
•Avoid: Calcium, magnesium (dairy/antacids) → reduces absorption.

🔹 Itraconazole (Antifungal prophylaxis) ⚠️
•Solution: EMPTY STOMACH ❌.
•Capsule: WITH FOOD for better absorption.

🔹 Posaconazole 💊
•Administration: WITH FOOD (high-fat meal).

🔹 Voriconazole ⚠️
•Administration: EMPTY STOMACH.
•Timing: 1 hour before or 1 hour after meals.

6️⃣ Immunomodulators

🔹 Thalidomide/Lenalidomide/Pomalidomide (MM) 💊
•Administration: WITH OR WITHOUT FOOD.
•Notes:
•Thalidomide → take at bedtime to minimize sedation.
•Avoid in pregnancy → Teratogenic ⚠️.

📝 Quick Reference Table

DrugAdministrationKey Notes
VenetoclaxWith Food 🍽️Reduces TLS risk, improves absorption
ImatinibWith Food 🍽️Reduces GI upset
NilotinibEmpty Stomach ❌Avoid food (QT prolongation)
Rivaroxaban ≥15 mgWith Food 🍽️Improves absorption
Methotrexate (MTX)With FoodReduces GI irritation
BortezomibWith or Without FoodAvoid grapefruit
Iron SupplementsEmpty Stomach ❌Better absorption; avoid calcium
Steroids (Prednisone)With Food 🍽️Prevents gastric irritation
Itraconazole SolutionEmpty Stomach ❌Better absorption
PosaconazoleWith Food 🍽️High-fat meal preferred

#HemeOnc #DrugSafety #PatientEducation #AdministrationTips #Hematology

[hugeasmammoth.films @hugeasmammoth_]

#thepitt

[kenzie xcx 🦋 @kenzie__xcx]

gonna just watch the entire season of the pitt again

[Danya @dxxnya]

unfortunately this video is like cocomelon to me. I have to fully stop what i’m doing, my show is on

[Pengu @Penguxn]

"you're actually fucking insane" god forbid i be myself

[☔ @Whotfismick]

“finally a day off”

My day off:

[kenzie xcx 🦋 @kenzie__xcx]

is it thursday yet

[izzy @spidermannwh]

#thepitt

[Dr. Rick Pescatore @Rick_Pescatore]

Thread: The ghosts we carry.

Not the ones in white sheets.
The ones with hospital bracelets.
The ones who die whispering.
The ones you don’t forget.
We all carry them.

Let me tell you about mine.

[shreya @shreyabasu003]

Passive aggressive cleaning

[Steve’s Bat @emteekellie]

Internalizing

[𝔽ℙℍ 🇺🇸 SF July 27-Aug 2 @FeralPHunter]

whats the female version of punching drywall

[Steve’s Bat @emteekellie]

@simplybenjito Ugh I’m like two weeks later 😭 would’ve been electric if we were there the same time 💔