EPIDATUM

Essential developments, informed discussion, and data, without the ideology and infotainment.

[EPIDATUM @epidatum]

#COVID19: Researcher blows the whistle on #data integrity issues in #Pfizer #vaccine trial

Company falsified data, unblinded patients, employed inadequately trained vaccinators, was slow to follow up on #AdverseReactions reported in pivotal phase 3 trial
https://t.co/JSZUFbKlZ1

[EPIDATUM @epidatum]

Anti-spike antibody response to natural #SARS_CoV_2 infection in the general population

"We estimated antibody levels associated with protection against reinfection likely last 1.5-2 years on average"
https://t.co/OulhxocOYO

[EPIDATUM @epidatum]

Effect of early treatment with #fluvoxamine on risk of emergency care and hospitalisation among patients with #COVID19: TOGETHER randomised, platform clinical trial

Treatment with fluvoxamine among high-risk outpatients reduced need for hospitalisation
https://t.co/YDO07FS71f

[EPIDATUM @epidatum]

Outbreak of #SARS_CoV_2 B.1.617.2 (#Delta) variant in a Nursing Home 28 weeks after two doses of #mRNA anti-#COVID19 #vaccines: evidence of a waning immunity

[EPIDATUM @epidatum]

Cardiac MRI Findings of #Myocarditis After #COVID19 #mRNA #Vaccination in Adolescents

5 patients, all males with age ranging from 16 to 19 years presented within 4 days of the second dose of #COVID19 #mRNA #vaccine without known prior #COVID-19
https://t.co/1RafW8Su70

[EPIDATUM @epidatum]

Computational Design of Potent D-Peptide Inhibitors of #SARS_CoV_2

The two best designs bound the RBD with affinities of 29 and 31 nM and blocked the infection of Vero cells by SARS-CoV-2 with IC50 values of 5.76 and 6.56 μM, respectively
https://t.co/v5LCcR8R3N

[EPIDATUM @epidatum]

U of T researchers create mirror-image peptides that can neutralize #SARS_CoV_2

Researchers at the University of Toronto @uoft have created chemical compounds that can neutralize SARS-CoV-2 and several of its #variants.
https://t.co/DOQBI2MMAl

[EPIDATUM @epidatum]

Identification of driver genes for critical forms of #COVID19 in a deeply phenotyped young patient cohort

"Among differentially expressed genes, we observed up-regulation of the metalloprotease ADAM9.
We identified ADAM9 as a driver of disease severity.
https://t.co/evTOWRcjm4

[EPIDATUM @epidatum]

The spike protein of #SARSCoV2 variant A.30 is heavily mutated and evades #vaccine-induced #antibodies with high efficiency
https://t.co/fx5NLmAwkz

[EPIDATUM @epidatum]

#SARSCoV2 infects human adipose tissue and elicits an inflammatory response consistent with severe #COVID19
"adipose tissue supports SARS-CoV-2 infection and pathogenic inflammation and may explain the link between #obesity and severe COVID-19"
https://t.co/VlRls2iMsk

[EPIDATUM @epidatum]

A review: #Antibody-dependent enhancement (#ADE) in #COVID19: The not so friendly side of #antibodies

Sub-neutralizing antibodies can facilitate uptake by macrophages that express FcR, with stimulation of macrophages and production of cytokines.
https://t.co/vWKJZdkO02

[EPIDATUM @epidatum]

#SARSCoV2 #variants of concern and variants under investigation in #England

Report contains information on variant AY.4.2 inc. 17% growth rate advantage for AY.4.2 over #Delta; 12% higher household secondary attack rate than Delta
https://t.co/rTMyw5RYja

[EPIDATUM @epidatum]

UK government secures groundbreaking #COVID19 #antivirals

The 2 antivirals are:
#Molnupiravir, UK government has secured 480,000 courses
PF-07321332/#ritonavir, UK government has secured 250,000 courses
https://t.co/8TxHsjdBOh

[EPIDATUM @epidatum]

#Valneva Reports Positive Phase 3 Results for Inactivated, Adjuvanted #CovidVaccine Candidate VLA2001. Neutralizing antibody seroconversion rate is above 95%.
https://t.co/pMEgmsZMfN

[EPIDATUM @epidatum]

Asymptomatic #SARSCoV2 #Vaccine #Breakthrough (VBT) Infections in HCWs Identified Through Routine Universal Surveillance Testing

Systematic surveillance of #vaccinated HCWs uncovers many times more cases of VBT infection than symptom-based testing.
https://t.co/ekp2lCt3cq

[EPIDATUM @epidatum]

Evidence for Biological Age Acceleration and #Telomere Shortening in #COVID19 Survivors

DeltaAge acceleration is 10.45 ± 7.29 years (+5.25 years above the range of normality) compared with 3.68 ± 8.17 years for the #Covid_19-free population.
https://t.co/t0opYH7tct

[EPIDATUM @epidatum]

A monoclonal antibody that neutralizes #SARSCoV2 variants, SARS-CoV, and other sarbecoviruses

Antibody 2-36 neutralized not only all current VOCs and SARS-COV, but also a panel of bat and pangolin sarbecoviruses that can use human ACE2 as a receptor.
https://t.co/5mk7BPvqrf

[EPIDATUM @epidatum]

Differential Effects of Antiseptic Mouth Rinses on #SARSCoV2 Infectivity In Vitro

A 5% (v/v) dilution of Colgate Peroxyl or povidone-iodine completely blocked viral infectivity. 50% (v/v) dilution of Listerine or CHG blocked viral infectivity completely.
https://t.co/vIqdeLlKoE

[EPIDATUM @epidatum]

Breastfeeding infants receive neutralizing #antibodies and #cytokines from mothers immunized with a #COVID19 #mRNA #vaccine

anti-RBD IgG and anti-RBD IgA was detected in 33% and 30% of infant stool samples, respectively
https://t.co/aiEgdYnvTp

[EPIDATUM @epidatum]

Association of #Vaccination With the Persistence of Post-#COVID Symptoms (PASC)

Study inc. 453 #Covid19 patients with #LongCovid, of which 324 (72%) were #vaccinated between baseline & 6-month visit.
Vaccination is not associated with improvement in PASC
https://t.co/AJSmAUHvQJ