#COVID19: Researcher blows the whistle on #data integrity issues in #Pfizer#vaccine trial
Company falsified data, unblinded patients, employed inadequately trained vaccinators, was slow to follow up on #AdverseReactions reported in pivotal phase 3 trial
https://t.co/JSZUFbKlZ1
Anti-spike antibody response to natural #SARS_CoV_2 infection in the general population
"We estimated antibody levels associated with protection against reinfection likely last 1.5-2 years on average"
https://t.co/OulhxocOYO
Effect of early treatment with #fluvoxamine on risk of emergency care and hospitalisation among patients with #COVID19: TOGETHER randomised, platform clinical trial
Treatment with fluvoxamine among high-risk outpatients reduced need for hospitalisation
https://t.co/YDO07FS71f
Outbreak of #SARS_CoV_2 B.1.617.2 (#Delta) variant in a Nursing Home 28 weeks after two doses of #mRNA anti-#COVID19#vaccines: evidence of a waning immunity
Cardiac MRI Findings of #Myocarditis After #COVID19#mRNA#Vaccination in Adolescents
5 patients, all males with age ranging from 16 to 19 years presented within 4 days of the second dose of #COVID19#mRNA#vaccine without known prior #COVID-19
https://t.co/1RafW8Su70
Computational Design of Potent D-Peptide Inhibitors of #SARS_CoV_2
The two best designs bound the RBD with affinities of 29 and 31 nM and blocked the infection of Vero cells by SARS-CoV-2 with IC50 values of 5.76 and 6.56 μM, respectively
https://t.co/v5LCcR8R3N
U of T researchers create mirror-image peptides that can neutralize #SARS_CoV_2
Researchers at the University of Toronto @uoft have created chemical compounds that can neutralize SARS-CoV-2 and several of its #variants.
https://t.co/DOQBI2MMAl
Identification of driver genes for critical forms of #COVID19 in a deeply phenotyped young patient cohort
"Among differentially expressed genes, we observed up-regulation of the metalloprotease ADAM9.
We identified ADAM9 as a driver of disease severity.
https://t.co/evTOWRcjm4
#SARSCoV2 infects human adipose tissue and elicits an inflammatory response consistent with severe #COVID19
"adipose tissue supports SARS-CoV-2 infection and pathogenic inflammation and may explain the link between #obesity and severe COVID-19"
https://t.co/VlRls2iMsk
A review: #Antibody-dependent enhancement (#ADE) in #COVID19: The not so friendly side of #antibodies
Sub-neutralizing antibodies can facilitate uptake by macrophages that express FcR, with stimulation of macrophages and production of cytokines.
https://t.co/vWKJZdkO02
#SARSCoV2#variants of concern and variants under investigation in #England
Report contains information on variant AY.4.2 inc. 17% growth rate advantage for AY.4.2 over #Delta; 12% higher household secondary attack rate than Delta
https://t.co/rTMyw5RYja
UK government secures groundbreaking #COVID19#antivirals
The 2 antivirals are:
#Molnupiravir, UK government has secured 480,000 courses
PF-07321332/#ritonavir, UK government has secured 250,000 courses
https://t.co/8TxHsjdBOh
Asymptomatic #SARSCoV2#Vaccine#Breakthrough (VBT) Infections in HCWs Identified Through Routine Universal Surveillance Testing
Systematic surveillance of #vaccinated HCWs uncovers many times more cases of VBT infection than symptom-based testing.
https://t.co/ekp2lCt3cq
Evidence for Biological Age Acceleration and #Telomere Shortening in #COVID19 Survivors
DeltaAge acceleration is 10.45 ± 7.29 years (+5.25 years above the range of normality) compared with 3.68 ± 8.17 years for the #Covid_19-free population.
https://t.co/t0opYH7tct
A monoclonal antibody that neutralizes #SARSCoV2 variants, SARS-CoV, and other sarbecoviruses
Antibody 2-36 neutralized not only all current VOCs and SARS-COV, but also a panel of bat and pangolin sarbecoviruses that can use human ACE2 as a receptor.
https://t.co/5mk7BPvqrf
Differential Effects of Antiseptic Mouth Rinses on #SARSCoV2 Infectivity In Vitro
A 5% (v/v) dilution of Colgate Peroxyl or povidone-iodine completely blocked viral infectivity. 50% (v/v) dilution of Listerine or CHG blocked viral infectivity completely.
https://t.co/vIqdeLlKoE
Breastfeeding infants receive neutralizing #antibodies and #cytokines from mothers immunized with a #COVID19#mRNA#vaccine
anti-RBD IgG and anti-RBD IgA was detected in 33% and 30% of infant stool samples, respectively
https://t.co/aiEgdYnvTp
Association of #Vaccination With the Persistence of Post-#COVID Symptoms (PASC)
Study inc. 453 #Covid19 patients with #LongCovid, of which 324 (72%) were #vaccinated between baseline & 6-month visit.
Vaccination is not associated with improvement in PASC
https://t.co/AJSmAUHvQJ