@TylerAlterman Same, why aren’t more people talking about this? Many are - it’s all over Reddit and other sm, but doesn’t seem a wide enough awareness or pushback that OAI are doing anything about it. 4o has been going severely downhill months now, and upping to o3 doesn’t seem to be a solve.
@mykola@mattshumer_ Yes, ouch, I’ve been burned. It hallucinates the reference quotes you actively ask for (with hallucinated section numbers). Would you consider a master prompt asking for hypertext links to all the material it provides critical to its answer (to click through to check that way)?
@Malcolm_Ocean True. I wonder a lot about where someone is well adapted to their environment and they allow (enable) it to function well, but their contribution (part they play) may not necessarily be the best adaptation of/for them. Can take a lot of time & maturity to realise & accept that🙂
@firtoz@petergyang How accurate have you found the results if you don’t mind me asking? It seems o3 is being tasked with far more demanding real estate analysis as well, but I am yet to see comments from informed parties verifying accuracy. Love to know, as would be a game changer for my research..
Dear Secretary Kennedy,
I was disappointed to hear of the delay of Novavax in regard to their BLA on the basis of it being a single antigen vaccine. I'm not sure whether you're referring to single antigen as targeting only one variant vs targeting different epitopes from the same variant.
There are two monovalent single antigen respiratory vaccines for HIB and RSV already in use. In decades of ER experience, I did not see one case of meningitis or epiglottitis due to HIB, and a seasoned ENT told me he hadn't seen a case of epiglottitis in 20 years!
If you're referring to bivalent/trivalent/quadrivalent vaccines, Novavax's bivalent vaccine was found to have the same coverage as its monovalent. In contrast, the most recent quadrivalent flu vaccine was found to have negative efficacy per Shrestha et al Cleveland Clinic.
If you're referring to multiple epitopes on the same pathogen, what you may not know is what appears common to both Novavax and multi-epitope live attenuated vaccines is that they both generally do not induce IgG4, which is a probable common mechanism to their effectiveness. In contrast, the mRNA's are known significant inducers of IgG4 which is the probable cause of the Shrestha et al findings 2022 Cleveland Clinic of more boosters being associated with more infections.
What you may also not know is that Novavax reduced nasal viral loads at statistically significant levels per Routhu et al in non-human primates when compared to both placebo and the mRNA's. Novavax might have actually been useful in preventing transmission.
I am also disappointed in your seemingly new found temperance in regard to the covid mRNA products. Following on Brogna et al's 2023 findings of recombinant spike protein fragments detectable in 50pct of mRNA vaccinees up to 6 months, Yale's Bhattacharjee has now delineated Post Covid Vaccine Syndrome as a persistent increase in mRNA induced spike protein levels up to 709 days. Bhattacharjee was also able to delineate an immunological phenotype of PVS substantially different from PASC of impaired CD4/CD8 ratios which is quite concerning.
Barring manufacturing issues which only the FDA is privy to, Novavax is clearly the safest and most effective covid vaccine currently available with multiple phase 3 studies and years now of data showing superior safety when compared to the mRNA's. If you end it despite it having already been essentially approved as a tool against the worst biowarfare event of our age yet remain silent on the covid mRNA flaws, one can only conclude that nothing at HHS has changed for the better.
I remain hopeful for true governmental reform. Please do not unduly delay or disapprove Nuvaxovid based on preconceived notions. Look at the data and allow those who are vaccine inclined to have it available as a NON-mRNA option as soon as practicable.
Thank you.
@SecKennedy@MartyMakary@DrJBhattacharya@FDACBER@CDCgov@Novavax@tracybethhoeg
@KllN349312@DonEford Additionally, as of 2 days ago, Australia’s intention for vaccines for the remainder of this year for C19 were announced and they were all Phizer. Our immunisation research and advisory bodies have very little interest in Novavax. It is a great shame for our country.
@KllN349312@DonEford I am aware, but the updated Novavax does not have approval from our regulatory body in Australia yet, in fact, approval has not yet been applied for. Last year our regulatory body failed to approve Novavax XXB after many months of waiting so the application was withdrawn 1/2
@KllN349312@DonEford As (non-emergency) approval hasn’t been granted for the updated version either in the US or Australia (where I am), and the current batch is about to expire, I’m concerned Sanofi will not be motivated to produce more on fast timelines. Australia hasn’t had any Novavax in 2 years.
@KllN349312@DonEford Based on research studies I have seen, in my personal opinion, the Novavax vaccine is superior to the alternatives in several ways, however it has less uptake than the others (again, imo, due to lack of awareness and information available as to the benefits).
@KllN349312@DonEford Would you mind sharing why you think this is likely? Without approval for their new updated formula, and generally lower uptake than the other brands, what will be the motivation to put a rush on manufacture of more batches?
@MNisselle@o_bel_ Me too. QLD. only non clinical family member. Only one CC. Did my head in but now realise being in frontline heathcare actively indoctrinates C19 minimising. Denial for survival - don’t think HCWs could stay in jobs otherwise - pressure to downplay is insidious and brutal.
@lollyfoot So Sorry💔My eldest (hcw) had it twice at least. Now
has ongoing gastro sensitivity issues. Youngest stared Uni and will be her first year of education not masking. Now we wait for the inevitable (smiling through clenched teeth pretending my heart’s not breaking)😶 It sucks ☹️
@drseanmullen So beautiful and a gut punch.. feel every single word. I protected mine as long as I could. For 3 years and 5 years. But one started work and now the other University. They cannot bear to be different and derided any longer. I understand but grieve. Protect yours while you can ❤️