Neurology resident🧠| Interested in neuroinflammatory CNS diseases | Tizi Ouzou, 🇩🇿 | Not a professional account—just here to repost what I should be studying
The dorsal column–medial lemniscus pathway carries discriminative touch, vibration, and conscious proprioception from the body to the primary somatosensory cortex through a three-neuron relay. First-order sensory axons enter the spinal cord and ascend ipsilaterally in the dorsal columns: the fasciculus gracilis carries input from the lower body, whereas the fasciculus cuneatus carries input from the upper trunk and upper limb. These fibers synapse in the gracile and cuneate nuclei of the caudal medulla. Second-order axons then decussate as internal arcuate fibers, forming the medial lemniscus, which ascends through the brainstem to the ventral posterolateral nucleus of the thalamus. From there, third-order neurons project through the posterior limb of the internal capsule to the postcentral gyrus, where the signal reaches the primary somatosensory cortex.
⏰️Time is Brain 🧠 in MOGAD! Early and Effective acute treatment impacts disability and long-term outcomes. Start and escalate quickly if poor response. Tocilizumab also useful in severe attacks! @NeuroinmunUC@TheMOGProject@TheSumairaFDN
https://t.co/wqp8acUWDd
13 year boy with slow movements, imbalance, and slurred speech after a respiratory illness. Spinal tap was positive for anti-MOG. Is this MOGAD? I don't think so. MT-ATP6 gene at 93.8% heteroplasmy levels (MT-ATP6 m.8993T > C), consistent with Leigh's https://t.co/FgJb4LZKu2
Can IL-6R blockers reshape acute treatment in #MOGAD and #NMOSD?
In our uncontrolled study, add-on #Tocilizumab/#Satralizumab was associated with clinical improvement after attacks!
Beyond acute treatment, IL-6 blockade may also prevent future relapses!
#PushForClinicalTrials