Elsayed Z. Soliman

[Wendy Wang @_wangwendy]

PUBLISHED in @JAMA_current: our recent ARIC findings suggest atrial myopathy may be a novel risk for dementia
@faye_epi @alonso_epi @gottesman_lab @LinYeeChen3

https://t.co/n9rHjfseMZ

[Elsayed Z. Soliman @ezsoliman1]

@guto_montezano @georgehret @HyperAHA Thank you everyone for your interest and the engaging discussion. #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@guto_montezano @georgehret @HyperAHA Q15: we do not know until we examine it. However, let us not put too much weight on subgroups. They are hypothesis generaring. #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@georgehret @HyperAHA @Hopitaux_unige @AtulPathak31 Q14....also, we should follow the current BP guidelines....Note: our results about preventing AF among HTN not addressing coexisting AF with HTN. . #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@georgehret @HyperAHA @Hopitaux_unige @AtulPathak31 Q14. Maintaining a heart-healthy lifestyle is always our best option. Understanding and seeking proper management of AF risk factors comes next. #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@guto_montezano @georgehret @HyperAHA Q13. The strength of association as we found in the REGARDS study could vary as we age. As for intensive vs. standard, we only looked at age cut-off 75 above and below. With the SPRINT age, it is hard to answer your question. #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@hswapnil @asouth_neph @HyperAHA @georgehret @statsepi We are talking about "well-conducted" trials, not any trial. In Sprint we adjusted for the clinical center network for example, but not for baseline characteristics. #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

Hi All- Please repeat your question if I missed it. @HyperAHA #HYPHIP

[Elsayed Z. Soliman @ezsoliman1]

@georgehret @HyperAHA Q12. In SPRINT, AF was defined by Minnesota ECG Classification which suppresses AF detection on certain occasions. We reviewed these ECGs and added more AF cases, Parcha V et al. did not. #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@hswapnil @asouth_neph @HyperAHA @georgehret In a well-conducted clinical trial, we do not need adjustment for baseline covariate. #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@georgehret @HyperAHA @Hopitaux_unige Q10. You already said- it has been widely discussed :) Remember SPRINT is a trial and any misclassification should have impacted both arms equally. So debates on ascertainments or measurements should not impact the conclusion but my impact the generalizability. #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@hswapnil @georgehret @HyperAHA Agree. This is one of the reasons the results of the subgroups need to be read with caution. #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@fjorios @HyperAHA Q10. They probably were taking other medications. However, this is a randomized clinical trial that ensures balance between groups. #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@georgehret @HyperAHA Q9b-Missing baseline or follow-up ECG. Presence of prevalent AF at baseline. #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@georgehret @HyperAHA Q6. I'd say within the range of what is expected given the main SPRINT results. #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@fjorios @HyperAHA Q5: SPRINT was designed to look at effect of individual drugs but a strategy. #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@guto_montezano @georgehret @HyperAHA Q8. Good question. We have not looked at this. We just used the same SPRINT main results plan. Will do #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@asouth_neph @HyperAHA @georgehret Q9. Power issue due to ascertainment by ECG only. #HYPHIP @HyperAHA

[Elsayed Z. Soliman @ezsoliman1]

@georgehret @HyperAHA Q3c. Our interpretation of the subgroups is based on Hommel adjusted p-values which take into account that for the race was 0.24. #HYPHIP @HyperAHA