Fact ZEB

Your go-to hub for all things Hemophilia A! Join us to learn, share, and support each other in raising awareness. Together, we can make a difference! 🩸💪

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CRISPR is a technology that research scientists use to selectively modify the DNA of living organisms. CRISPR was adapted for use in the laboratory from naturally occurring genome editing systems found in bacteria.

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Check out our latest reel:

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Part 3:

Determining residual plasma concentration of factor VIII represents the keystone of diagnosis, classification, and treatment of hemophilia A as therapy and prognosis will vary depending on factor VIII deficiency.

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Part 2:

Normal hemogram and prothrombin time in the setting of elevated activated partial thromboplastin time heightens the suspicion of hemophilia and should prompt factor VIII and IX determination.

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Evaluation of Hemophilia A (Part 1):

Diagnostic evaluation for hemophilia occurs in the setting of a known family history, excessive bleeding out of proportion to the traumatic injury, or abnormally activated partial thromboplastin time.

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Inhibitor development represents a major complication and challenge in hemophilia treatment because these alloantibodies inactivate the procoagulant effect of infused factor VIII, thereby inhibiting the response to factor VIII replacement.

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Many severe hemophilia A patients, nearly 30%, develop alloantibodies against administered factor VIII.

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Hemophilia A is the most common X-linked hereditary disorder of hemostasis; it occurs in one out of 5000 males and accounts for 80% of hemophilia cases. Hemophilia A occurs in more than 400000 males worldwide, many of whom remain undiagnosed in the developing world.

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Hemophilia, which means love (philia) of blood (hemo), manifests with prolonged and excessive bleeding either spontaneously or after insignificant trauma.

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We are working on an exciting genetic project about gene therapy for Hemophilia A. We'd be thrilled to have your support and engagement in our journey.

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In spontaneous mutation scenarios that occur in one-third of cases, hemophilia A diagnostic confirmation proceeds after bleeding symptoms occur spontaneously or after insignificant trauma.

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In two-thirds of cases, confirmation of the hemophilia diagnosis occurs shortly after the delivery of an affected son to a mother who carries the susceptible gene.

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Şiddetli hemofili genellikle yaşamın ilk aylarında ortaya çıkarken, hafif veya orta dereceli hemofili çocukluk veya ergenlikte, genellikle tesadüfen veya travmadan sonra ortaya çıkar.

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Severe hemophilia often manifests in the first months of life, whereas mild or moderate hemophilia will present later in childhood or adolescence, often incidentally or following trauma.

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