Fanpu Ji

Professor of hepatology/ID & Physician at the Second Affiliated Hospital of Xi'an Jiaotong University🇨🇳
Major in #HCC #Sarcopenia #Fibrosis #MASLD

[Fanpu Ji @FanpuJi]

@ElonMuskNews47 Yes

[Fanpu Ji @FanpuJi]

@YeeHuiYeo1 @BrennanSpiegel @LiranOmer @ItaiDanovitch @JuDongYang1 恭喜毅辉兄弟！👍👍

[Fanpu Ji @FanpuJi]

@wonglaihung @CUHKMedicine @CUHKGI @UMichMedSchool @MichiganLiver @ebtapper @GraceSu15 @VWSWong @TerryYip12 @HenryLYChan @norahterrault 👍👏

[Fanpu Ji @FanpuJi]

🌟New study shows #Sinomenine (SIN), a natural alkaloid, protects against #fibrosis in mice & #HSCs by blocking TGF-β/SMAD & c-JUN signaling.
📉 ↓ Collagen & α-SMA
🛡️ ↓ Liver injury & inflammation
🚀 SIN = a promising anti-fibrotic therapy!
https://t.co/TeWkYkhxLJ

[Fanpu Ji @FanpuJi]

@A_DAlessioMD @EASLedu @EASLnews 👍👍👍👍

[Fanpu Ji @FanpuJi]

📢New in #Hepatology:
AI model (preoperative CT & clinical data) predicts #HCC recurrence.
✅Predicts recurrence 1–5 years out with AUROC ~0.8
✅Beats microvascular invasion & multiple clinical risk scores
🔗https://t.co/Vl00XSsHew
#LiverCancer #DeepLearning @WK_Seto @RexWHHui

[Fanpu Ji @FanpuJi]

📉 New insights into #MASLD-#cACLD
1️⃣ First #decompensation ↑ liver-related death risk 18.9-fold ☠️
2️⃣ Further decompensation adds 1.52-fold risk ⚠️
3️⃣ Ascites is the most common event
4️⃣ #HCC worsens outcomes🧬
5️⃣ High extrahepatic death burden due to metabolic risk ❤️🧠

[Fanpu Ji @FanpuJi]

📢New in @JCSM_cachexia :
Combining fat distribution + BMI redefines obesity.

Centripetal obesity indicators outperformed BMI alone in predicting all-cause mortality.
It’s time to rethink how we define and evaluate #obesity in clinical practice.
🔗https://t.co/WVXFrjsu5k

[Fanpu Ji @FanpuJi]

How does your diet affect liver health?
🍽️High branched-chain amino acids (BCAAs) intake ↑ #MASLD risk
🟢Higher arginine intake ↓ risk significantly
💪Balanced amino acid profiles are key for prevention
#NutritionScience #AminoAcids #MetabolicHealth
🔗https://t.co/flQjCxBVca

[Fanpu Ji @FanpuJi]

@BrennanSpiegel Big congratulations Dr. Spiegel! Great work!

[Fanpu Ji @FanpuJi]

🧬Can #geneediting fight #liverfibrosis?
#CRISPR & other tools precisely target fibrosis pathways, offering hope for liver disease & cancer.
🎯 Precise & powerful
⚠️ Challenges remain
🚀 #Precisionmedicine for liver disease is on the horizon!
https://t.co/pm5Fc2BHJ6

[Fanpu Ji @FanpuJi]

🧫 Mesenchymal #stemcells (#MSCs) suppress pro-fibrotic intrahepatic B cells via exosomes, easing #liverfibrosis by blocking MAPK/NF-κB pathways
📉 ↓ B cell activation
📉 ↓ Inflammation & collagen
🧬 B cells = new therapeutic target
https://t.co/kwXKlcbAcI

[Fanpu Ji @FanpuJi]

🔥Myocardial infarction fuels #MASH progression by:
✅Triggering immune-inflammatory cascade
✅Inducing periostin expression 🧬
💔 Heart attacks worsen liver fibrosis
Key link between heart & liver health! 🩺
#MI #InflammationResearch #Periostin
🔗https://t.co/ZbEqQOUdzV

[Fanpu Ji @FanpuJi]

Waist-based indices > BMI for predicting both #MASLD and fracture risk.
🤔The relationship between #Sarcopenia and MASLD remains unclear.
😯Finding better BMI alternatives to better understand how adiposity drives liver and muscle disease.
@JCSMJournal 🔗https://t.co/WiMWV2gxA4

[Fanpu Ji @FanpuJi]

🚨 Vitamin D isn't just for bones🦴—it may reduce liver inflammation & fibrosis!
🟡 Low vitamin D = worse liver outcomes
🧪 TXNIP knockout = more fibrosis
🎯 Vitamin D/TXNIP axis = a promising therapeutic target!
#LiverDisease #Fibrosis #VitaminD #TXNIP
👉🏻https://t.co/EknOPKqfoC

[Fanpu Ji @FanpuJi]

#Atezolizumab + #Bevacizumab vs #HCC 🔬
#scRNAseq unveils two response patterns: immune-mediated & angiogenesis-linked
🔍 IDs key cells/pathways driving primary resistance
🌟 Provides framework for patient stratification & overcoming treatment resistance
🔗https://t.co/3C1TG8d9Pz

[Fanpu Ji @FanpuJi]

🧬 Early #MASLD fights #HCC
🐭 In mouse models, steatosis inhibits HCC development
⚙️ Activates #Yap/Taz, boosting hepatocyte fitness
💥 Healthy #hepatocytes eliminate tumor-initiating cells via cell competition (not toxicity)

👉https://t.co/Ru0kadMf8l

[Fanpu Ji @FanpuJi]

@ArndtVogel @TheLancet @myESMO @EASLedu @ILCAnews ✊

[Fanpu Ji @FanpuJi]

@RajivJalan1 @drgautammehta 👍👍

[Fanpu Ji @FanpuJi]

🔬 New Study on #MASLD!

1️⃣AI-based FibroNest reveals 327 hepatic fiber phenotypes 🧬
2️⃣ #FibroPC4 linked to gene signature predicting #HCC development 📊
3️⃣ #IGFBP-7 transforms HSCs into HCC phenotype💥

https://t.co/X4GSw1zCIN