Fergus O'Farrell

Doctor (Neuropathology) & Neuroscience postdoc. PhD via @UCL_MBPhD. Neuron-glial-vascular interactions, physiology. 🌿📚🏳️‍🌈 he/him

[Fergus O'Farrell @fergusofarrell]

Brain capillary in an acute cortical slice. Imaged by me 6 years ago today (according to my phone).

[AHA Science @AHAScience]

Published today, Vascular Contributions to Cognitive Impairment (VCID) and Brain Health: Clinical Update and Mechanistic Considerations.

This paper proposes that multi-mechanistic origins of VCID and time-appropriate interventions that complement VRFs modification are important to maintaining brain health and preserving cognitive function across the lifespan.

📷 Conceptual diagram of vascular contributions to age-related cognitive decline and worsening brain health.

[Fergus O'Farrell @fergusofarrell]

Neurodegenerative diseases need more mechanism-informed trials
https://t.co/yHEnhKfMLY

[Fergus O'Farrell @fergusofarrell]

The source, because no one bothers these days...:
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins https://t.co/eWXII31YwZ

[Andrew Côté @Andercot]

A realistic picture of how closely packed molecules are inside a synapse of a nerve cell.

[Fergus O'Farrell @fergusofarrell]

GLP-1 activates KATP channels in coronary pericytes as the effector of brain-gut-heart signalling mediating cardioprotection
https://t.co/A8r2qiBf6D

[Fergus O'Farrell @fergusofarrell]

Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence: Cancer Cell https://t.co/PHzhOBCibJ

[Fergus O'Farrell @fergusofarrell]

@ilovepathology Happy New Year, and enormous congratulations, Dame Suzy! 🥳

[Brain @Brain1878]

Jean-Martin Charcot was born in Paris on 29 November 1825. @ajlees marks the bicentenary of Charcot's birth by reflecting on how his scientific legacy continues to shape neurology today. https://t.co/ExO6Vy9Hny

[Simon Mead @smead2]

Papers like this which demonstrate that alpha synuclein can act potently as prions, are exactly why you need to have proportionate safety measures in labs doing this kind of work. If you work on this and don’t have safety measures ask why! Great paper btw. https://t.co/qoRaVNLdVh

[Fergus O'Farrell @fergusofarrell]

Lymphoid gene expression supports neuroprotective microglia function
https://t.co/80mqNcqitO

[nature @Nature]

Nature research paper: Adenosine signalling drives antidepressant actions of ketamine and ECT

https://t.co/MxaGj7kqNp

[John Lukens @LukensJohnR]

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease @NatureNeuro
https://t.co/Poy7fNXGDp

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human

https://t.co/bBbIaM2n6r

[Rong Fan @RongFan8]

Thrilled see our paper out in @Nature ! 🤩 Wonderful collaboration with @GoCasteloBranco. Kudos to my amazing postdoc @Di_0579 at @YaleEngineering and Leslie Kirby from Goncalo's lab @karolinskainst. Huge team science with @YaleMed @UCSF @ASTARsg
https://t.co/IF7XbnS1q0

[Joseph G. Gleeson @jogleeson_ucsd]

Check out our new resource paper @CellStemCell, where we present a brain organoid atlas of human neurodevelopmental disorders. Surprising was that nearly all patients had abnormal organoids. The challenge was aligning defects to clinical. https://t.co/0YtGTd4Dwb

[Neuron @NeuroCellPress]

Online now: The brain neurovascular epigenome and its association with dementia https://t.co/gVqKCwvrng

[Nature Metabolism @NatMetabolism]

The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease https://t.co/8A7nkyRxw9

[Earl K. Miller @MillerLabMIT]

Today, I teach the (graduate) kids about long-term memory. I'm bringing along my 3D print of HM's brain, made from post-mortem histology. #neuroscience

[Fergus O'Farrell @fergusofarrell]

The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and neuroinflammation | Science Advances https://t.co/pZtMH3mOkX

[Dr. Axel Montagne, PhD @AxL_Montagne]

Excited to share our @CurrentBiology Primer written with @AudreyChagnot in the Brain-Body Interactions special issue!

We discuss how the BBB works, what happens when it breaks down, and why this matters for brain and body health.

@UKDRI @TheBHF

https://t.co/QnwkVuHEWh

[Abha Karki Rajbhandari, PhD @BrainBody_Lab]

An amazing collection of brain-body interaction articles in this special issue. Love the beautiful vagus nerve on the cover by Andreas Vesalius https://t.co/K1El0JuJDX