Matt

Interested in health.
Not advice. Just documenting some of my thoughts.

[Matt @finally_matt]

Ray Peat:
Regular sleep is a powerfully protective thing. It should be somewhere in the range of six to nine hours every night, but the regularity is very important. It becomes a built-in, almost a machine-like regularity, once you get a schedule set. And any variation of

[Matt @finally_matt]

@exfatloss @trikomes There are limitations to n=1’s. Whether high LDL makes me die younger from heart disease is not something I want to learn from my n=1

[Matt @finally_matt]

Seemingly, if we wanted the best chance of finding evidence that PUFAs are bad for humans, we’d look at overweight elderly individuals (oxidative stress & inflammation high enough to cause substantial lipid peroxidation) who have had a high-PUFA diet for a while (enough time to

[Matt @finally_matt]

@CatOfLongTails Still digging. If there is convincing evidence of harm from dietary PUFA in humans, it’s hard to find.

[Matt @finally_matt]

It’ll take a while, but I’m going to have to dig through the fatty acid research myself to feel satisfied.

I’m open to PUFA being good for you and SFA being bad for you, I have no horse in this race.

[Matt @finally_matt]

@Leo_Abstract @exfatloss @trikomes I really appreciate it, I’ll get to reading all of these

[Matt @finally_matt]

@exfatloss @trikomes If I based my approach to nutrition on n=1s that have been documented on the internet, I could justify almost anything.

[Matt @finally_matt]

@trikomes @exfatloss Thank you… I plan on working through those soon.

By the way, I enjoyed your conversation with Dr. Bill Harris and the back-and-forth you two had about n-6’s.

I think we should all be open to changing our beliefs if presented with sufficient evidence, even longstanding ones

[Matt @finally_matt]

@exfatloss @trikomes Thanks, I’ve been going through some of his content lately.

Is there any quality human evidence that you’re aware of that shows harm from PUFAs?

[Matt @finally_matt]

@beelibers I think all of us are going to have higher levels of oxidative stress and inflammation in old age

[Matt @finally_matt]

@paige_eden Basically, what I’m trying to find out is whether consuming PUFA itself is harmful or beneficial, and how/if that varies between the individual fatty acids (LA, ALA, DHA, EPA, AA, etc)

[Matt @finally_matt]

@paige_eden I think so; what I’m moreso interested in is whether PUFAs are harmful in general. Even if we assume they’re beneficial, getting that same PUFA from nuts comes with upsides (polyphenols, micros, etc), while cooking with the oils has theoretical downsides (hexane, etc)

[Matt @finally_matt]

What if some people care more about being anti-mainstream than they do about finding the truth?

[Matt @finally_matt]

@TuckerGoodrich that might only be a small % increase, compared to how many more polyphenols they’re getting.
I haven’t seen convincing evidence that lowering LDL is harmful, all else being equal, as of yet.
2/2

[Matt @finally_matt]

@TuckerGoodrich I see how it could be difficult to parse out whether the reduced risk of all-cause mortality is from the nuts or the relative increase in n-6. 1-3 oz of walnuts, which showed positive effects, is 10-30g LA. But if their baseline diet is already rich in LA,
1/2

[Matt @finally_matt]

@nageco @TuckerGoodrich @exfatloss I appreciate it, I’m working through watching a few podcasts episodes with Tucker. If you can think of anyone else, I’m all ears.

[Matt @finally_matt]

@QuirkCorey I haven’t look at the evidence myself, but I’ve heard people, including Dr. Chris Masterjohn, mention that mothers who consume more DHA give birth to more intelligent children

[Matt @finally_matt]

@peter_peater That’s an interesting theory. It seems like we’d have to decide what proxies to use for speed or aging and compare them in people with higher vs lower PUFA diets

[Matt @finally_matt]

@beelibers I agree, at least in the short-term. Some people argue that in a person who’s prone to oxidative stress / inflammation, the body having higher PUFA stores will make their fat more prone to lipid peroxidation

[Matt @finally_matt]

@texugodum3l Very interesting. I wonder how proportional that age-related increase in n-6 in human particular cartilage is to dietary n-6 intake. Any thoughts on that?

[Matt @finally_matt]

@texugodum3l If we’re concerned about inflammation from n-6 depleting NAD+, would the short-term human trials showing that seed oils don’t increase inflammation be enough to alleviate that concern?

[Matt @finally_matt]

@texugodum3l

[Matt @finally_matt]

@EagleTwoRomeo Of course. I’m still really quite new to digging through the research so hopefully nobody takes me too seriously. But I post on here to document my thoughts and because hearing other people’s thoughts is really helpful