Amanda Fitzpatrick

Clinical Senior Lecturer @Kings College London. Medical Oncologist @Guy’s and St Thomas’ NHS Trust. Brain mets researcher. @WSETglobal Level 3 certified

[Yakup Ergün @dr_yakupergun]

HER2+ mMBC in asymptomatic patients, proactive cranial screening:

→ Symptomatic brain metastases: 0% vs 9.5%

→ Brain metastases detected smaller and with better performance score

→ Reduced need for WBRT

https://t.co/5GBleLfRKX

[Amanda Fitzpatrick @fitzpat_a]

Thought provoking talks on the booming field of #cancerneuroscience & the promising new treatment approaches using existing drugs to modulate neuronal mechanisms #EANO2024 @wick_wolfgang @humsav @Winkler_Lab

[Amanda Fitzpatrick @fitzpat_a]

So good to see this data showing effectiveness of an ADC in patients with active brain metastasis - hope it paves the way for many more to come!

[Annals of Oncology @Annals_Oncology]

New article in press: A Pooled Analysis of Trastuzumab Deruxtecan in Patients With HER2-Positive Metastatic Breast Cancer With Brain Metastases. @FAndreMD @curijoey @Prof_Nadia_H
https://t.co/f1nXq63DZ7

[Nancy Lin, MD @nlinmd]

TBCRC 049: Tucatinib, trastuzumab, capecitabine for HER2+ LMD
-The first prospective LMD trial to show all of the following:
-therapeutic drug levels in CSF
-intracranial response
-improvement in symptoms and QoL
-extended OS compared to historical controls

[Amanda Fitzpatrick @fitzpat_a]

@sflomos @TheEndoSociety @BreastCancerNow @epflSV Very important work!! 🙌

[Amanda Fitzpatrick @fitzpat_a]

This will be great - and in my hometown!

[EANO @EANOassociation]

📣Have you heard? Abstract submission for #EANO2024 is now open and closes on April, 30! Don't miss the chance to present your work in #NeuroOncology. The 19th Meeting of the EANO will be held in Glasgow (UK), Oct 17-20, 2024. See you there! 👉https://t.co/8RlgVc2Md2 #btsm

[Amanda Fitzpatrick @fitzpat_a]

@UteJungwirth @UniofNewcastle @NBioscience @NU_Cancer So exciting @UteJungwirth!!

[Amanda Fitzpatrick @fitzpat_a]

Super excited by this new finding - could this also be a potential route for metastatic cells to invade the CNS?

[Leon Smyth @lcdsmyth]

I am excited to share our latest research on the arachnoid barrier, a crucial yet poorly understood structure that partitions the CNS and the dura, out today @Nature. We discovered that gaps in this barrier allow communication between the CNS and the dura. https://t.co/tP4TIc986A

[Margaret Frame @MargaretFrame11]

stunning….

[Becki Lee @BeckiLee]

Some news coverage of our CAcTUS trial using ctdna to decide when to switch treatment -shows what it means for patients - although the data is very early and still to be understood properly!
https://t.co/jcefCKnmnV

[Duke Center for Brain and Spine Metastasis @DukeMets]

#ICYMI @CancerTodayMag wrote up the panel that @CareyAnders1 led at @SABCSSanAntonio last month! Check out the link to read about treatment options for #brain metastases in #BreastCancer.

https://t.co/E1NVru83yo

[Amanda Fitzpatrick @fitzpat_a]

@dimarcobarrosr Adorable!! Congrats @dimarcobarrosr!!

[Amanda Fitzpatrick @fitzpat_a]

Really important work from the @dr_yinwu lab @KingsCollegeLon, dissecting the role that γδ T cells play in determining response to immune checkpoint inhibitors. 👏 https://t.co/kcf4I2TilR

[Amanda Fitzpatrick @fitzpat_a]

@dr_yinwu Sorry @dr_yinwu just spotted this!! Answer not known yet - but one I’ll be addressing in a new pan-cancer LM study across @kingshealth in collab. with the @FinnertyLab 👍

[Amanda Fitzpatrick @fitzpat_a]

Hugely grateful to all involved academically in this work, patients, funders @The_MRC @BreastCancerNow @RMresearch_ @kingshealth and the clinical centres involved @GSTTnhs @royalmarsdenNHS

[Amanda Fitzpatrick @fitzpat_a]

Is metastatic spread to the leptomeninges simply the end process of a widely metastatic cancer, or does it have its own unique metastatic drivers and evolve early in the disease? Read all about it in my paper recently published https://t.co/GGLmfWUIKO @ICR_London @KingsCollegeLon

[Amanda Fitzpatrick @fitzpat_a]

@UteJungwirth @emlay53 @LifeScienceBath Amazing!!

[Amanda Fitzpatrick @fitzpat_a]

Excited to get started on this project developing liquid biopsy methods to more accurately define patients benefiting from immunotherapy - with Yin Wu @dr_yinwu @kingshealth @KingsCollegeLon

[Saheli Sadanand @SaheliSadanand]

🌟NEW @NatureMedicine: interim results of the first trial evaluating concurrent intrathecal + IV anti-PD-1 in patients with #melanoma & #leptomeningealdisease Great work led by @GlitzaMDPhD #MichaelDavies @HTawbi_MD @MDAndersonNews #immunotherapy https://t.co/uluhVMSKV9

[Guy's and St Thomas' @GSTTnhs]

Our clinical leaders are very concerned about the potential harm to patients that may be caused by the upcoming junior doctors’ strike.

We are calling on the Government and unions to do everything in their power to suspend the strike.

https://t.co/GAvqnDrPki

1/5