Fizza Akbar

Genetic Counselor & Genomics Researcher, Senior Instructor @AKUGlobal MSc. Genomic Medicine, Grad Cert. Alumnus @FCCollege @OfficialUoM @UBC🧬🇵🇰

[Fizza Akbar @Fizzakbar]

Genetics is a journey, in the true sense of the word. From the odyssey to diagnosis, from denial to acceptance, from one to family, from a nucleotide to a syndrome impacting lives of clans. And we become a part of their journey. Just like that! #GCchat

[Ariana Jasmine @arianajasmine__]

I don’t think you understand how catastrophic the oil refinery bombing in Tehran is.

Burning petroleum releases sulfur and nitrogen oxides that mix with rain to form sulfuric and nitric acid, essentially turning rainfall toxic.

When Saddam burned Kuwaiti oil wells in 1991, the fallout contributed to what became known as Gulf War Syndrome, with veterans developing chronic illness and cancer decades later.

The difference now: this isn’t a desert battlefield, it’s a city of 10 million people, most of which women and children.

[Ammar Ali Jan @ammaralijan]

83 children killed by Israeli attack on Lebanon. After murdering 70000 children in Gaza, the Epstein class is targeting children of all those forces who stood up for Palestinian children.

Stopping the US-Zionist war on children is the greatest moral imperative of our time.

[M. Jibran Nasir 🇵🇸 @MJibranNasir]

عورتوں کا عالمی دن۔

[Nav Toor @heynavtoor]

🚨BREAKING: OpenAI published a paper proving that ChatGPT will always make things up.

Not sometimes. Not until the next update. Always. They proved it with math.

Even with perfect training data and unlimited computing power, AI models will still confidently tell you things that are completely false. This isn't a bug they're working on. It's baked into how these systems work at a fundamental level.

And their own numbers are brutal. OpenAI's o1 reasoning model hallucinates 16% of the time. Their newer o3 model? 33%. Their newest o4-mini? 48%. Nearly half of what their most recent model tells you could be fabricated. The "smarter" models are actually getting worse at telling the truth.

Here's why it can't be fixed. Language models work by predicting the next word based on probability. When they hit something uncertain, they don't pause. They don't flag it. They guess. And they guess with complete confidence, because that's exactly what they were trained to do.

The researchers looked at the 10 biggest AI benchmarks used to measure how good these models are. 9 out of 10 give the same score for saying "I don't know" as for giving a completely wrong answer: zero points. The entire testing system literally punishes honesty and rewards guessing.

So the AI learned the optimal strategy: always guess. Never admit uncertainty. Sound confident even when you're making it up.

OpenAI's proposed fix? Have ChatGPT say "I don't know" when it's unsure. Their own math shows this would mean roughly 30% of your questions get no answer. Imagine asking ChatGPT something three times out of ten and getting "I'm not confident enough to respond." Users would leave overnight. So the fix exists, but it would kill the product.

This isn't just OpenAI's problem. DeepMind and Tsinghua University independently reached the same conclusion. Three of the world's top AI labs, working separately, all agree: this is permanent.

Every time ChatGPT gives you an answer, ask yourself: is this real, or is it just a confident guess?

[Maleeha Lodhi @LodhiMaleeha]

Shameful

[Ammar Ali Jan @ammaralijan]

All of Pakistan joins you in mourning and solidarity. Its not only a loss for Iran but for all people in the region who are facing Zionist and imperialist aggression. May Imam Ali Khamenei's legacy inspire all those who are resisting Yazidiyat. Victory & glory to Iran, always!

[Mohamad Safa @mhdksafa]

Imagine if Iran bombed Washington and killed students in schools, what would you call it? Terrorists

The U.S. and Israel bombed Tehran and killed students in schools. Why do you call it a "pre-emptive strike"?

Bombing a school is a war crime under international humanitarian law

[Ammar Ali Jan @ammaralijan]

"An evil man will burn his own nation to the ground to rule over the ashes"

[Mehdi Hasan @mehdirhasan]

There is always a tweet

[water and joints. @waterandjoints]

Humaira left her home chasing dreams, and for that, her family disowned her. The world wasn’t kind, and her plans fell apart. She was left with nothing, no money, no home to return to. Even her corpse rejected. Ahh, Society punishes women for daring to live the life they want.

[CGA-IGC @CGAIGC]

📢It's Day 2⃣of #HereditaryCancerWeek‼️

We're🧐at the recent release of the @NCCN Guideline Update for #PancreaticCancer🔎

➡️Consider #PancreaticCancer🔍for all #BRCA2 & ATM pathogenic variant carriers starting at age 50, even w/out known👪history of PDAC. More⤵️
@josiebakerGC

[Fizza Akbar @Fizzakbar]

@Jenniferfg82 @WilhelmFound @UDNIss Likewise! I will keep in touch and hopefully we meet again next year 😊

[Fizza Akbar @Fizzakbar]

Three days of sheer joy, positive energy, learning and feeling connected to serving a meaningful purpose, it has been a privilege! Huge shoutout and gratitude to the entire organising team and colleagues
@WilhelmFound @UDNIss
#undiagnosedhackathon2024

[Ambrin Fatima @AmbrinFatima1]

The past three days were so wonderful and motivating for us to continue working for the rare. Heartfelt thanks to Nijmegen’s hospitality, @ahoischen energy, @GeneticNijmegen’s facility & @WilhelmFound’s vision
#undiagnosedhackathon2024

[Alexandra Davies @Alex_Doune]

My lab @MCF_UoM is #hiring a Research Technician. I'm looking for someone with experience in #iPSC & #microscopy. You will be trained in #proteomics and the project will tackle the mechanisms underlying rare neurological diseases.
Apply now!
https://t.co/YIAYh70a85
#pleaseshare

[Fizza Akbar @Fizzakbar]

Here to advocate for the rare, learn from global experts and hoping to solve some complex cases 🧬🧬
#undiagnosedhackathon2024

[Ambrin Fatima @AmbrinFatima1]

What an absolute privilege to see the giant of genomics James Lupski receive the Mendel award at the #eshg2024

[European Society of Human Genetics (ESHG) @eshgsociety]

Chromosomes gleam bright,
Twenty-three pairs, sculpted grace,
Highest honors shine. 🌟🧬
#haiku #genetics #eshg2024

[Ambrin Fatima @AmbrinFatima1]

AKU folks presenting Pakistan at #ESHG2024 🧬🙌🏽

[Daniel MacArthur @dgmacarthur]

Stellar plenary from @ksamocha on the @gnomAD_project v4 release at #eshg2024. It is, she notes, a remarkable time to be a human genomicist: many available datasets with >100K sequenced people. However, still massive under-representation of non-European ancestry.