Olivia
Online
New CDC study: 75% of US adults support wastewater monitoring, and 95% say they would take steps to protect themselves if wastewater data showed disease spread was high.
We need to fund wastewater monitoring and include the data in daily weather reports, so everyone is aware.
Turlock, California
H5 detection, second in September, again a bolus which might come from heat-treated milk at a dairy or discarded milk from a Grocery store.
@HelenBranswell @PeacockFlu @0bFuSc8 @SolidEvidence @CDCFlu @FluRadar_
Analysis of the #H5N1 sequence from the presumed H2H transmission in Missouri finds two concerning mutations:
1. Likely reduces effectiveness of antibodies derived from the current H5N1 vaccine.
2. May moderately increase infective in humans.
Shared exposure? Food poisoning?
Missouri's health department confirms "household contact" of bird flu case sickened last month
Both had symptoms onset "on the same day"
Contact wasn't tested because "too late for PCR testing to occur effectively"
https://t.co/2viwm1pFxi
🚨📣 Anticipated sequence from human #H5N1 case in Missouri w/ lack of clear exposure source, just released by @CDCFlu through @GISAID [EPI_ISL_19413343]. Clade 2.3.4.4b, similar to dairy cattle H5N1 virus. Sample collected 8/22/24, sequence took over 3 weeks to release!
Source of infection investigation ongoing, but very interesting to see HA sequence relation to Texas dairy cow in April.
H/t @HealthyLivingMO @cdcflu for sharing data.
https://t.co/a2pFMgIKWK
![RickABright's tweet photo. 🚨📣 Anticipated sequence from human #H5N1 case in Missouri w/ lack of clear exposure source, just released by @CDCFlu through @GISAID [EPI_ISL_19413343]. Clade 2.3.4.4b, similar to dairy cattle H5N1 virus. Sample collected 8/22/24, sequence took over 3 weeks to release!
Source of infection investigation ongoing, but very interesting to see HA sequence relation to Texas dairy cow in April.
H/t @HealthyLivingMO @cdcflu for sharing data.
https://t.co/a2pFMgIKWK](https://pbs.twimg.com/media/GXYdSVmWsAAb6kl.jpg)
The NEJM paper on sequencing wastewater for #H5N1 is particularly important because it allows us to understand when the virus is adapting toward human-human transmission. It seems that multiple mutations would be necessary for this scenario to occur, but knowing when it is happening could trigger escalation of the response.
"Of importance, a glutamic acid, instead of lysine, in position 627 of PB2 suggests that this virus has not extensively adapted to humans (see Table S2, which shows all unique single-nucleotide polymorphisms)."
@RanuDhillon @sri_srikrishna
https://t.co/zdMxemoe7I
We've been sequencing wastewater for 2.5 years. In 2024, H5N1 started showing up. Our findings are published in the New England Journal of Medicine.
Sequencing-Based Detection of Avian Influenza A(H5N1) Virus in Wastewater in Ten Cities
w/ @TEPHI_Texas
https://t.co/rvVdnCZSCL
An update on probe of Missouri human case of H5 bird flu that @CDCgov confirmed last week
Spokesperson for state health department says:
"All contacts remained asymptomatic throughout the observation period."
https://t.co/jwdcZfeZSs
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