Fred Bard

Sr. Principal Investigator at Institute of Molecular and Cell Biology

[Fred Bard @fred_bard]

Musing over some change for 2023 https://t.co/jGWOI4k1kX.

[Fred Bard @fred_bard]

I've just contributed to STOP Croisières. Consider supporting them too — every little helps! https://t.co/enxDxpRKSn via @opencollect

[Timothy Snyder @TimothyDSnyder]

"Some observers of the Russo-Ukrainian war seem to think that its greatest danger is that Ukraine will win, or win too quickly, and that this will be uncomfortable for Putin, and that we should care. This is a deeply perverse way of seeing things."
https://t.co/NTfi1pDf8f

[Timothy Snyder @TimothyDSnyder]

Graduation day in Kharkiv, Ukraine

[Raphael Glucksmann @rglucks1]

Nos dirigeants répètent en boucle que l’Histoire est redevenue tragique. Mais quand agiront-ils en conséquence? Ont-ils vraiment compris que l’avenir de l’Europe se décidait dans les ruines de Marioupol et les rues de Kyiv?

[Fred Bard @fred_bard]

https://t.co/1Q6edBarZE

[Fred Bard @fred_bard]

Russian dolls, multiscale project: study protein glycosylation in the Golgi of a cancer cell in an organoid injected in an organ.
https://t.co/9fFYOvX2t4

[Fred Bard @fred_bard]

Sea, Sun and Science in Marseille: a postdoc position opened in my new lab!
https://t.co/9fFYOvX2t4

[Fred Bard @fred_bard]

You can now read about the "Kiss of Src" at: https://t.co/iLmwsVTuxL
How Src does it to GBF1 and how it makes it leave the Golgi, taking the tubular car, Arf1 and the GALNTs with it ... PG13 for scenes of extensive phosphorylation!

[Fred Bard @fred_bard]

See more at:
https://t.co/F7Rqol4yDy

[Fred Bard @fred_bard]

Thanks to everyone who contributed to the publication today in AJHG!

[Fred Bard @fred_bard]

A highly conserved gene, a protein without equivalent, human mutants with massive brain developmental defects, zebrafish mutants with epileptic tendencies. C2ORF69: a mysterious yet essential human gene.

[Ajay Mathuru @MathuruLab]

What an amazing story that is out today; both, the publication and the making of! Great that we could contribute to this project.@reversade @fred_bard @Holab_DukeNUS @MaurerStroh Congratulations 🥳 Hui Hui. https://t.co/qZBT9R6HuC

[Fred Bard @fred_bard]

@GDarmanin En 1956, les ecoles primaires abolissaient le vin à la cantine. En 2021, il est temps d’arrêter la viande. Pour le futur de tous; ce n'est pas de l’idéologie, c'est du réalisme: on ne va pas contenir le réchauffement sans faire de sacrifice.

[Fred Bard @fred_bard]

Indeed! The textbook models of vesicular traffic appear less and less phased with reality.

[Francesca Bottanelli @Fran_Bottanelli]

Nice to see how ARF1 function in the formation of tubules we described back in 2017 https://t.co/jB5MzMgLJO is regulated! but maaan this COPI results leaves me baffled...

[Francesca Bottanelli @Fran_Bottanelli]

Nice to see how ARF1 function in the formation of tubules we described back in 2017 https://t.co/jB5MzMgLJO is regulated! but maaan this COPI results leaves me baffled...

[Fred Bard @fred_bard]

Thanks Fran! Very kind of you. Really liked your 2017 paper too.

[Francesca Bottanelli @Fran_Bottanelli]

Interesting from @fred_bard! Src phosphorilates the GEF GBF1 which activates ARF1 for tubules formation while COPI vesicle formation is unaffected!

[Fred Bard @fred_bard]

Beautiful modelization. Glycosylation changes with age, it is also variable between individuals. Could it explain some of the differences in severity observed among patients?

[Oliver Grant @Olivercgrant]

Glycosylated SARS-Cov-2 Spike Trimer. Biantennary LacNAc N-glycans (18 per protomer) are shown in dark magenta. Protein is from Swiss-Model (based on 6VSB), glycans built using https://t.co/lX8uga8Tzz. #glycotime #COVIDー19 @SWISS_MODEL @glycam

[Fred Bard @fred_bard]

@Olivercgrant @SWISS_MODEL @glycam Beautiful re-construction. Interesting to think that glycosylation patterns change a lot with age, they also vary between individuals. Could these patterns explain some of the stark differences that are observed between patients?

[Fred Bard @fred_bard]

#Covid_19fr
Herd immunity: 20th century
Testing, tracking and isolating: 21st century