Gathersight

A network of scientists, researchers, academics and biotech specialists sharing their insights and opinion in short 5-15 minute recorded video calls.

[Gathersight @gathersight]

#CRISPR/Cas9 enables gene studies with tools like optogenetics, but AAV limits packaging. This Cre-dependent Cas9 strategy enhances specific editing in neurons. #GeneEditing
Daily biotech insights 👉🏼 @gathersight. https://t.co/sm7BxIKc87

[Gathersight @gathersight]

Achieving precise gene regulation in mammalian cells requires systems with perfect adaptation. #CRISPRa and anti-CRISPR proteins enable dynamic, stable gene expression control. Daily biotech insights 👉🏼 @gathersight. https://t.co/PLkvHb2m69

[Gathersight @gathersight]

The integration of NAA with #CRISPR has advanced molecular diagnostics, but CRISPR-NAA incompatibility hinders commercialization. One-pot CRISPR assays offer solutions. Daily biotech insights 👉🏼 @gathersight. https://t.co/FYH2mzFnlB

[Gathersight @gathersight]

#CRISPR-Cpf1, known for its precision and efficiency, is a key tool in disease model construction and gene therapy despite some off-target effects. #GenomeEditing. Daily biotech insights 👉🏼 @gathersight. https://t.co/s97krAsQGf

[Gathersight @gathersight]

#CRISPRi, using a deactivated Cas protein and guide RNA, enables gene silencing without permanent edits, revolutionizing genome-wide screens. #GenomeEditing. Daily biotech insights 👉🏼 @gathersight. https://t.co/CfvsqQGIDy

[Gathersight @gathersight]

A nanozyme-boosted #MOF-CRISPR platform (CMOPKP) maintains redox homeostasis and alleviates cognitive impairment in 3xTg-AD mice. Daily biotech insights 👉🏼 @gathersight. https://t.co/VMk0EIBsy9

[Gathersight @gathersight]

Exo-III/#Cas12a amplification and a smartphone fluorescence detector enhance POCT for nucleic acids, enabling precise, portable diagnostics. Daily biotech insights 👉🏼 @gathersight. https://t.co/3EvSANRCwj

[Gathersight @gathersight]

Nanozymatic sensors using Fe-N-C SAzymes and #CRISPR/Cas12a offer a sensitive, specific method for AFB1 detection, advancing public health monitoring. Daily biotech insights 👉🏼 @gathersight. https://t.co/X8awjO85GH

[Gathersight @gathersight]

#CRISPR-Cas9 is revolutionizing liver disorder treatments like transthyretin amyloidosis. This review highlights key findings and challenges. #GenomeEditing. Daily biotech insights 👉🏼 @gathersight. https://t.co/xbrPIivyxG

[Gathersight @gathersight]

Type I #CRISPRi system reconstituted in B. subtilis enhances DPA production by fine-tuning metabolic flux. Elevated DPA titer achieved in fermentation. Daily biotech insights 👉🏼 @gathersight. https://t.co/iCi4bITfgt

[Gathersight @gathersight]

#CRISPECTOR2.0 quantifies allele-specific #GenomeEditing, addressing off-target effects and enabling safer personalized #CRISPR applications. Daily biotech insights 👉🏼 @gathersight. https://t.co/dtEmOP6Ivn

[Gathersight @gathersight]

#CRISPR/Cas12a dual-crRNA screening enables high-fidelity genetic interaction discovery, promising for HCC drug target identification. Daily biotech insights 👉🏼 @gathersight. https://t.co/XbyklyyoRf

[Gathersight @gathersight]

#CRISPR–Cas systems can counter anti-CRISPR (Acr) factors via phage-derived toxins that trigger abortive infection-like effects, expelling Acr elements. Daily biotech insights 👉🏼 @gathersight. https://t.co/l2heKYqydu

[Gathersight @gathersight]

Research experiences in STEM are crucial for student growth. An 8-week #CRISPR training program in C. elegans showed enhanced skills and enthusiasm. Daily biotech insights 👉🏼 @gathersight. https://t.co/SMqfSN1YrX

[Gathersight @gathersight]

#CRISPR/Cas12a's application in biosensors is hindered by high background signals. The PAIT effect offers a solution, enhancing detection accuracy for non-nucleic acid targets. Daily biotech insights 👉🏼 @gathersight. https://t.co/1l4DljOqSp

[Gathersight @gathersight]

Glaucoma, affecting 80M globally, was mitigated in female mice using #CasRx to target Rock1/2, AQP1, and β2-AR, reducing intraocular pressure. Daily biotech insights 👉🏼 @gathersight. https://t.co/OZAcXnAvGC

[Gathersight @gathersight]

HMPV poses a global health challenge due to the lack of vaccines or specific treatments This study developed a rapid One-tube assay using RT-RPA and #CRISPR/Cas12a for accurate HMPV detection. Daily biotech insights 👉🏼 @gathersight. https://t.co/GA1IVyY4vs

[Gathersight @gathersight]

#EpigenomeEditing, utilizing #CRISPR, alters gene expression via heritable, reversible epigenetic mechanisms, offering therapeutic potential. Daily biotech insights 👉🏼 @gathersight. https://t.co/PIyyIpCrQP

[Gathersight @gathersight]

Utilizing AZD7648 to enhance HDR efficiency in CD34+ HSPCs, this study achieved ~60% HDR at CD40LG and improved long-term engraftment, offering a potential therapy for X-linked hyper IgM syndrome. #GeneEditing. Daily biotech insights 👉🏼 @gathersight. https://t.co/L5v9M6Ofhm

[Gathersight @gathersight]

Genetic engineering, particularly #CRISPR, offers precision in #GenomeEditing. This review discusses advancements in delivery systems to enhance efficacy and reduce side effects. Daily biotech insights 👉🏼 @gathersight. https://t.co/tDVV0PJ8vz