The central dogma of molecular biology: EMBL Pic of the Week
Biological information flow – from DNA to mRNA to protein – depicted in a single structure. EMBL’s Mahamid group used cryo-electron tomography to determine the structure in bacterial cells.
https://t.co/Sat0sTMiC0
Mallory, Nakhleh and co review methods for detecting copy number aberrations in single-cell DNA sequencing data, from the perspective of cancer genomics. They discuss the seven basic steps involved in segmenting the genome, and then describe 8 methods https://t.co/S48PJcDOl6
This simulation illustrates the flexibility of the spike proteins (red, orange, blue and grey) and their glycan coats (green).
Credit: Sören von Bülow, Mateusz Sikora, Gerhard Hummer/MPI of Biophysics
Welcome, Georgia Rapti!
New EMBL group leader @gerapti is exploring the development of the nervous system in early embryos.
Read more about her in our interview: https://t.co/tbHKmQLsMr
📸 Joseph Franciosa/FranciosaFotograf
Kremsky and @CorcesVictor look at DNA methylation during germ cell development and pre-implantation development. 78% of CpGs have their methylation restored after global demethylation. Those that are bound by transcription factors are not remethylated https://t.co/daTI1ZlMl8
tappAS: from @dlfuente_lorena, @anaconesa and co, for isoform-centered functional analysis of differential transcript usage. It is demonstrated on long and short read data from two different mouse neural cell types https://t.co/GPHjG9OJzL
Here Fehr et al., summarize the current understanding of the mechanisms by which PARPs promote or suppress pro-inflammatory activation of macrophages, and also discuss various other roles PARPs play in virus infections. @BrighamWomens#GDSpecialIssue
https://t.co/fynHEVdk8m
In this Review, Kim et al. discuss the importance of PARP family members and ADPRylation in gene regulation, mRNA processing, and protein abundance. @UTSWNews#GDSpecialIssue
https://t.co/UgkiflJFjz
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West Point and Annapolis officials are trying to determine the motives of service academy students who flashed hand signs on national television that in certain contexts are associated with “white power" https://t.co/pEl85LP4qd