Genetic Code Lab, Doshisha University

Laboratory for Genetic Code, Graduate School of Life & Medical Sciences, Doshisha University, Japan. PI : Akira Kobayashi, 同志社大学大学院 生命医科学研究科 医生命システム専攻 遺伝情報研究室

[Genetic Code Lab, Doshisha University @geneticcodelab]

We identified that NRF3 (NFE2L3) is a transcription factor that responds to diminished arginine levels.
"NRF3 activates mTORC1 arginine-dependently for cancer cell viability."
https://t.co/nm4muWAhJ6
#NRF3 #NFE2L3 #NRF2 #mTORC1 #arginine

[Genetic Code Lab, Doshisha University @geneticcodelab]

The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation.
https://t.co/WBVF2FfByu
#NRF3 #NFE2L3 #NRF2 #melanogenesis #autophagy

[Genetic Code Lab, Doshisha University @geneticcodelab]

We reported that the transcription factor NRF1 (NFE2L1) maintains protein homeostasis by activating aggrephagy through upregulating expression of p62 and GABARAPL1 under proteasome dysfunction.
https://t.co/NFjUz0Rmnu
#NRF1, #NFE2L1, #NRF2, #NRF3, #p62, #autophagy

[Genetic Code Lab, Doshisha University @geneticcodelab]

Our paper regarding molecular mechanisms underlying the NRF3-regulated SREBP2-dependent mevalonate pathway is out.
https://t.co/Ubr8FsbIfy
#NRF3 #NFE2L3 #NRF2 #SREBP #lipid

[Genetic Code Lab, Doshisha University @geneticcodelab]

Our new review regarding the pathological roles of the transcription factor NRF3 (NFE2L3) in cancer is out. https://t.co/HAzjJwXdYm #NRF3 #NFE2L3 #NRF2 #NFE2L2 #p53 #Rb #Proteasome #Cancer

[Genetic Code Lab, Doshisha University @geneticcodelab]

Our paper regarding the novel regulatory mechanism of basal proteasome activity in cancer cells through an NFE2L3–CPEB3–NFE2L1 translational repression axis is out.
https://t.co/6Z2LhjWSM8
#NRF3, #NFE2L3, #NRF1, #NFE2L1, #NRF2, #NFE2L2, #Proteasome, #CancerResearch

[日刊工業新聞電子版 @Nikkan_BizLine]

同志社大・東大など、がん細胞　増殖・転移促進遺伝子「NRF3」を発見
https://t.co/T966r5hDid

[日本の研究.comニュース @rjp_news]

【注目プレスリリース】がん細胞の増殖・転移を促進する新たながん遺伝子を発見 –転写因子 NRF3 によるタンパク質分解の異常制御を介したがん増悪メカニズム– / 同志社大学 https://t.co/AgGQZqbeJx

[Genetic Code Lab, Doshisha University @geneticcodelab]

Our paper regarding pathophysiological roles of the transcription factor NRF3 (NFE2L3) in cancer is out. https://t.co/yujcChCzMH #NRF3 #NFE2L3 #NRF2 #NFE2L2 #NRF1 #NFE2L1 #Proteasome #p53 #Rb #CancerResearch

[bioRxiv @biorxivpreprint]

NRF1 and NRF3 complementarily maintain a basal proteasome activity in cancer cells through CPEB3-mediated translational repression https://t.co/aQyxgFVk5F #bioRxiv

[Genetic Code Lab, Doshisha University @geneticcodelab]

Our review regarding the physiological roles of the transcription factor NRF3 (NFE2L3) in cancer is out. https://t.co/yEwkhDdasI #NRF3 #NFE2L3 #NRF2 #NFE2L2 #NRF1 #NFE2L1 #Cancer

[Genetic Code Lab, Doshisha University @geneticcodelab]

Our paper regarding a molecular mechanism of NRF3 (NFE2L3) induction in cancer cells has been published. https://t.co/FGKdSZ76I0 … #NRF3 #NFE2L3 #NRF2 #NFE2L2

[Genetic Code Lab, Doshisha University @geneticcodelab]

#MyOAarticle Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation received 632 pageviews since its publication. Access the article here: https://t.co/q7UaAR5rQG