Wow, this is a pretty striking result for my Strong Epigenetic Theory of Aging: transplant an old heart into a young animal and the heart is rejuvenated. But transplant a young heart into an old animal, and it quickly ages to match the recipient.
This shows that biological age is not simply something an organ accumulates locally as irreversible “wear and tear.” Instead, to a large degree, it is a state imposed by the organism-wide environment.
The authors saw bidirectional remodeling of both DNA methylation and gene expression, with old hearts in young hosts moving toward youthful programs and young hearts in old hosts moving toward aged ones.
That is exactly what you’d expect to see if aging is a regulated, system-level state where the epigenome is acting as the writable control layer that tissues continuously adjust to the organism’s age.
Severely autistic, non-verbal 4yo child is given high-dose folate (leucovorin)
- Gains speech in the first week and learns to walk
- Can speak 100 words after 1 year, maintains eye contact and physically active
- When he misses a dose, he relapses
This treatment is insane
Testimonial from a follower
A 12 year old boy walks into my office having already seen a psychiatrist, an allergist, a lung doctor, maybe a GI doctor. Seven different drugs by age 12. Kicked out of kindergarten for being disruptive. Diagnosed with ADHD and put on stimulant medication for years.
Nobody connected the dots. He also had asthma, headaches, stomachaches, insomnia. Each doctor treated their one piece and ignored the rest.
I did a full workup instead of writing another prescription. His gut microbiome was a mess. Leaky gut. Elevated gluten antibodies. Reacting to dairy. Fungal overgrowth. Low zinc, low magnesium, low B6, low folate, low omega 3s. Lead toxicity.
He ate only processed food. Never a vegetable in his life.
So we removed the gluten, dairy, sugar and processed food. Rebuilt his microbiome with probiotics. Treated the fungal overgrowth. Chelated the lead. Corrected the nutrient deficiencies with magnesium, zinc, fish oil.
Two months later his mother brought him back. No more symptoms. No more meds. No more behavioral issues.
And his handwriting went from illegible to perfect penmanship. Same kid, same brain, two months apart.
That handwriting change is what made me write The UltraMind Solution. A brain that chaotic and disorganized became coherent and synchronized once we fixed what was happening in his body. The writing on the page was just a reflection of what was happening in his gut.
ADHD is not a brain problem. It's a systemic problem that shows up in the brain. If your kid's brain isn't working right, don't just look north of the neck. Look at what's happening south of the border first.
Up to 76% of children with autism may actually have an autoimmune disorder which blocks uptake of folate into the brain, leading to a cerebral deficiency
Autistic children were 19 times more likely to test positive for folate receptor alpha antibodies, which bind with and block folate receptors at the blood-brain-barrier
These children had normal blood results, but very low levels in cerebrospinal fluid
Treatment with a specialized folate supplement, calcium folinate/folinic acid (aka Leucovorin), led to improvement in ~65% of autistic children studied
Standard testing is useless because blood levels of folate show up as normal, but the brain is deficient
Ordinary folate supplements (folic acid, methylfolate) are ineffective because their transport system is blocked
Calcium folinate, on the other hand, works by penetrating the brain via alternative transporters (reduced folate carriers) to effectively restore folate levels
However it must be taken in extremely high doses to achieve this effect. Leading physicians are using approx. 2mg/kg body weight.
Refs:
PMID: 38392599
PMID: 38248763
PMID: 34834493
PMID: 32892962
Mitochondrial health is passed through the X chromosome, so a man’s mitochondrial health can only be passed to ~half his daughters & none of his sons
Which means if men want mitochondrially healthy sons, they MUST select mitochondrially healthy mates
Thus female beauty is biologically more valuable than male beauty, as the mother’s mitochondria is 3x more likely to be expressed in offspring
Of course almost nobody knows this is the reason men are programmed to seek beauty and women are programmed to hate those who have more than them
We just launched what I believe is the best video model in the world.
• Faster than real-time generation at both 480p and 768p
• SOTA-level quality, built on MiniMax H3
• Prompt upsampling in ~1 second
This was a massive ML + engineering achievement by the @PrunaAI team.
And somehow, what we’re shipping next week is even more exciting.
https://t.co/zCjnOc3EuG
“Is it ok?”
PM Modi appeared to notice Chinese President Xi Jinping looking uncomfortable during his opening remarks at the BRICS Summit, and asked him, “Is it ok?”
According to Du Wen @duwen2023, a former CCP official, Xi Jinping is suffering from cerebellar atrophy. It is a difficult condition to deal with, because unlike problems with some other organs, the cerebellum cannot simply be replaced through a transplant.
Not long ago, purported medical records also surfaced online, allegedly hacked from Beijing’s 301 Hospital, which provides medical care to China’s top leaders. The records reportedly showed that Xi had undergone two MRI scans recently.
Judging from various signs, it seems quite possible that Xi Jinping is indeed experiencing health problems.
Just shipped the MCP and also made the project completely open source.
Ask your Claude code or Codex agent to build scene or even build features on top.
Check out the project here - https://t.co/Yv2NBgYa1M