Jodie Foster dijo una vez: "No, amigos. No sean tan inocentes. A los que hacen cosas malas no siempre les va mal. A muchos les va a ir bien. Los vas a ver triunfar. Los vas a ver quedarse con la mejor parte de todo. Y ese es el mundo real. Pero si esto les sirve de consuelo, puedo decirles que he visto muchos malvados exitosos... pero nunca en paz."
Los putisimos guiris defendiendo el derecho a estar en España sin integrarse una mierda porque "están jubilados" y no "chupan del estado español". Como si no usaran nuestra sanidad y como si no se apropiaran de nuestras ciudades expulsando a la población local.
Women: *give birth to literally every single human being that has ever walked this planet*
A tiny % of men in the 21st century: "We possess magical woman souls; therefore, we are literal women."
Everyone: I have no idea what a woman is now.🤷♀️
This isn’t a random scientist who got lucky.
Mariano Barbacid discovered the first human oncogene in 1982. He isolated H-RAS from bladder cancer cells and proved a single point mutation could trigger cancer. That finding launched the entire field of molecular oncology.
KRAS mutations cause 90% of pancreatic cancers. For 43 years, oncologists called KRAS “undruggable” because the protein had no obvious binding pocket. Barbacid spent the last decade using genetically engineered mice to systematically test every node in the KRAS signaling pathway, looking for combinations that would work without killing the patient.
The triple therapy blocks KRAS three ways at once: the main growth signal, the escape routes through EGFR and HER2, and the stress-response backup through STAT3. Cut the engine, seal the exits, disable the emergency system. Tumors vanished in mice and didn’t return for 200+ days after treatment stopped.
Pancreatic cancer has a 13% five-year survival rate. 8% for the ductal adenocarcinoma type this therapy targets. Most patients live one year after diagnosis.
The catch: this is preclinical. Human trials are 3+ years away. One of the drugs, RMC-6236, might get approved this year, but the full triple combination has regulatory hurdles.
Still. The man who discovered human oncogenes in 1982 may have just figured out how to eliminate the cancer those genes cause. That’s a 43-year arc from first principles to potential cure. Science rarely works this clean.
This is really one of the more galling parts of this discourse every time it pops up; random American civilians are supposed to be calm, disciplined, ice-water in their veins, but armed agents of the state are entitled to take life on the basis of “feelings”
“Men go through false rape cases” ok then stop having sex with women. Don’t put yourself in dangerous situations. Stay home. Don’t let women into your house. Don’t give sexual vibes. Be a good boy and don’t ask for it.
My unpopular opinion is body positivity should be about being okay with not looking good or conventionally attractive and not insisting we’re all beautiful. Our worth shouldn’t hinge on being pretty.
Misandry isn’t real. It affects absolutely nothing in real life. It’s not systemic and is nothing more than women saying “i hate men” on the internet BECAUSE of misogyny (femicide, rape, assault, etc). They’re not comparable in the slightest
Can we please stop saying there are two genders?
There are two sexes.
“Gender” is just sexist stereotypes.
Replacing the word sex with gender is what got us in to this mess.
Just wait for the paint to dry, then paint that end.
Moral lesson: If you wait to understand how to finish, you may never begin. Just start, you'll figure it out along the way.
if my great-grandmothers could see me, in my 30s with no children, studying anthropology and reading books and writing novels, they would sink to their knees and weep with joy